Bryan Lenneman

Phage N4 uses a SAR endolysin-holin system for host cell lysis biorxiv.org/content/10.110… #biorxiv_micrbio

Leveraging Klebsiella PhageBank @Klebsi_Ella_R @mark_mimee describe Klebsiella PhageBank for design of phage cocktails that suppress carbapenem-resistant K. pneumoniae in mouse gut. Phage-bacterial interactions shape bacterial virulence & phage host range cell.com/cell-host-micr…

My colleague, @BCherayil, and I review the impact of prenatal infection and vaccination on developing offspring immunity in this On the Horizon article. @mghfc From Womb to World: Exploring the Immunological Connections between Mother and Child journals.aai.org/immunohorizons…

Doctors are running out of antibiotics to treat their patients — & the costs of inaction threaten the health and financial well-being of every American. My bill, the PASTEUR Act, would revitalize development of the next generation of antibiotics. theepochtimes.com/opinion/we-are…

Getting ready for #ASMicrobe #ASM2024! Come see my student Sydney present her #Shigella project on Sunday in the HMB-IDS-006 Symposium "Integrating In Silico Models in Host-Microbe Biology". Session convened by @AlisonCrissUVA and looks interesting! 🧫🦠 @ASMicrobiology

Dr. Christina Faherty and her team at @harvardmed want to help make the first-ever vaccine for Shigella—a pathogenic bacteria in the human digestive tract. Their creation of malnourished #organoids could play a key role in making that vaccine a reality: bit.ly/4bFfSQY

@WHO just releases the 2024 Bacterial Priority Pathogens List of public health importance to guide R&D, and investments in #AMR prevention and control in measures to address emerging public health threats. Full report: who.int/publications/i…

Having models to simulate disease is a key part of finding treatments. For @ChristinaFaher1 and her team from @MGH_Mucosalists, that means creating malnourished versions of organoids to help find a vaccine for #Shigella Read more about their research: mgriblog.org/2024/05/10/how…

Thank you @MGH_RI for the feature on our ongoing #Shigella research & recent efforts to establish #malnourished #organoids! Thanks to Meryl Perlman now at @WUSTLPeds, @MicrobefanSmr, & all authors/lab members over the years! @mghfc @novonordiskfond @gatesfoundation @DefeatDD

Mass General researcher Christina Faherty, PhD, is using creative techniques to better understand the mechanisms of shigella infection. mgriblog.org/2024/05/10/how… @ChristinaFaher1 @MGH_Mucosalists

💡 🎥 🎬 ! Happy to share our #Shigella epithelial cell infection protocols that include analyses for adherence, invasion, and intracellular replication. Great job Kender @KenderPoore and Bryan @br_lenneman! jove.com/t/66426/epithe…

Dr. @ChristinaFaher1 and team from @harvardmed utilized malnourished #organoid-derived monolayers to evaluate the effect of malnourishment on barrier formation and the ability of the bacterial pathogen Shigella flexneri to infect the GI epithelium. ✅ bit.ly/3Q3n4hM

✨New Article! We describe a method to culture & study #malnourished #organoids! 🧵 tandfonline.com/doi/full/10.10…

Works for #MicroscopyMonday too 😄

For #FluorescenceFriday, sharing human duodenal #organoids stained for nuclei (blue), ZO-1 (red), and Muc2 (green). Beautiful images obtained by Dr. Smriti Verma @MicrobefanSmr! Stay tuned for an exciting announcement related to these images! #mucusmatters #microscopy #GI @MGH_RI

Had a wonderful time listening to some inspiring science at #ASMicrobe. Thanks to @ASMicrobiology and the Peggy Cotter Travel Award for giving me the opportunity to share my #phage engineering work to target #Shigella!

#ASMicrobe Today is the day! See Bryan @br_lenneman present his project on #phage engineering to target #Shigella! Looks like a great session too! Thank you to the organizers for this opportunity and to @ASMicrobiology for Bryan's Peggy Cotter Travel Award!

Announcing exciting presentations for #BBM2023 and #ASMicrobe! @br_lenneman will have two #phage oral presentations at each meeting & we'll have 2 additional #Shigella posters @BostonBacteria. Thank you to @ASMicrobiology NE Branch for Bryan's Peggy Cotter travel award!