Sreenath Balakrishnan

298 posts

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Sreenath Balakrishnan

Sreenath Balakrishnan

@bsreenath84

Applying mechanics to biological systems. Assistant Professor @IIT Goa.

Goa, India Katılım Temmuz 2009
297 Takip Edilen297 Takipçiler
Sreenath Balakrishnan
Sreenath Balakrishnan@bsreenath84·
Amen
Santosh Bhargav@DBSbhargav

Every cell in your body has mechanical properties — stiffness, elasticity, deformability. A cancerous cell behaves differently from a healthy one. An embryo's stiffness shifts as it develops. At @BendFlexRD, we've been building micro scale compliant mechanisms to explore this space — tiny biomanipulation tools that can hold, roll, squeeze, and pull a single cell and measure how it responds to force. The question we keep chasing: can mechanical signatures complement chemical assays in diagnostics? We don't have all the answers yet. But 15 years of working on mechanics of cells, tissues, and growth, and 40+ publications tells us the question is worth asking. #MechanoDiagnostics #DeepTech #BendFlex #CellMechanics #Biomanipulation #MakeInIndia

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Sreenath Balakrishnan
Sreenath Balakrishnan@bsreenath84·
The outlines of this work were drawn during the @IndiaBioscience Young Investigator's Meeting in Feb 2020 just before the pandemic. After several twists and turns, the work has finally taken shape. Thanks to @nathsangeetha for the perseverance
Sangeeta Nath@NathSangeeta

Happy to share our new pre-print on Mechanical signalling in TNT formation and recovery of toxic astrocytes. Thanks @bsreenath84 and @SivaramanLab for your support and collaboration biorxiv.org/content/10.648…

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Rahul Raj
Rahul Raj@x_rahulraj·
Madhava of Sangamagrama (c. 1340–1425) was one of the most brilliant yet underappreciated mathematicians in history. As the founder of the Kerala School of Astronomy and Mathematics, he discovered remarkable infinite series for trigonometric functions and for π centuries before similar ideas appeared in European calculus. His work showed extraordinary mathematical insight and precision, laying foundations that anticipated key concepts of modern calculus. Yet, despite his profound contributions, Madhava remains surprisingly little known both in India and globally. With @faisalart2006, we are working on a comics with a central character who loves Maths and engineering. His name is Madhava.
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Rahul Raj@x_rahulraj

Madhava of Sangamagrama (c. 1350 – c. 1425), the founder of the Kerala school of astronomy and mathematics expanded sinx in x. sinx = x − x3/3! + x5/5! − x7/7! + ... Newton (1642-1727), DeMoivre (1707-38) and Euler (1748) used it later. The equation still fascinates me.

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Shantanu Pradhan
Shantanu Pradhan@PradhanLab·
Here, we describe the the multiscale structure and mechanobiology of the bone, nanoscale to microscale force propagation, and its application in in vitro and bone-on-chip microphysiological platforms for disease modeling and drug screening applications.
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Ajay Tijore
Ajay Tijore@AjayTijore·
An exciting study from 'Mechanobiologics Lab' is out in 'Biomaterials' Journal. It reveals how ultrasound induces mechanoptosis in cancer-associated fibroblasts, weakening tumors from within. This work was led by Gomathi (PhD) and Arka Roy (MTech). lnkd.in/gSNSvM2y
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Denis Wirtz
Denis Wirtz@deniswirtz·
This is what the human fallopian tube looks like as one travels through its different sections. We have developed a new 3D single-cell tissue mapping workflow to automatically/accurately detect ovarian cancer precancerous lesions (STICs). More here: biorxiv.org/content/10.110…
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kuba sędziński
kuba sędziński@ksedzinski·
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
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Tamal Das
Tamal Das@tamal_das·
We study what organelles do - beyond their "textbook" functions - during development and wound healing. Here is a story on how ER morphology shapes cells' response to wound curvature: nature.com/articles/s4155… .. Details👇.. Thanks @ANRFIndia @shivkuma_k @TIFRH_buzz for support🙏
Simran Rawal@SimranRawal2

(1/n) Excited to share that my PhD work @tamal_das Lab is now published in @NatureCellBio! How do epithelial cells around a gap sense edge-curvature? We find that the ER acts as a central mechanotransducer, sensing the curvature & guiding cell migration. nature.com/articles/s4155…

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Lammerding Lab
Lammerding Lab@LammerdingLab·
Interested in #mechanobiology of the cell nucleus? The submission deadline for the FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation. #MBNSRC events.faseb.org/event/Mechanob…
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EMBL Events
EMBL Events@EMBLEvents·
⏰ Final call for abstracts for #EESNucleus! 📥 Submit your abstract by 26 August: s.embl.org/ees25-07-x Come and join the brand new EMBO | EMBL Symposium: 'Cell biology of the nucleus' 🌟 Don't miss your chance to discover the cutting-edge research shaping our understanding of the nucleus - from its dynamic architecture and mechanics to its role in cell division and pathology ⚛️ Session topics include: 🧬 Evolution of the nucleus 🧬 Biophysics of the nucleus 🧬 Dynamic nuclear architecture 🧬 Mechanics of the nucleus 🧬 Nuclear signaling and communication 🧬 Nuclear envelope and nuclear transport 🧬 Cell division and the nucleus 🧬 Nuclear pathomechanisms 🗓️ 18 – 21 November 2025 🗺️ EMBL Heidelberg and Virtual
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Shantanu Pradhan
Shantanu Pradhan@PradhanLab·
Happy to share the first pre-print from our lab. Here we show that 3D matrix adhesivity, degradability, porosity, and stiffness conjointly regulate the cellular and nuclear morphology and confinement in tunable microenvironments. biorxiv.org/content/10.110…
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Shashi Thutupalli
Shashi Thutupalli@stpalli·
We're looking for creating engineers/tinkerers/tool builders that want to engage with cutting-edge research questions. Please help me share the word!
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Ajay Tijore
Ajay Tijore@AjayTijore·
2nd paper from Mechanobiologics Lab is out in Journal 'Small' @AdvPortfolio. This work led by my 1st PhD student Alka. Superb collaboration with @ahcells & Rudra Pratap @CeNSEatIISc. We discovered how confined spaces in tissue reduce tumor cell killing upon ultrasound treatment.
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BE, IISc
BE, IISc@BE_IISc·
📢 We’re now on YouTube! We’ve launched our official channel to showcase the exciting world of bioengineering—from research and faculty insights to student journeys and department events. Like, Share and Subscribe to the channel. @DeptofBioengineeringIISc" target="_blank" rel="nofollow noopener">youtube.com/@DeptofBioengi…
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Keşfet

@IITGoaofficial @IndiaBioscience @nathsangeetha @faisalart2006 @tamal_das @ANRFIndia @shivkuma_k @TIFRH_buzz