byard

@Jeffliu6068Liu @ycombinator @sklin_lite @LiYaoHuang2 would be great to chat. I've been thinking about this problem for a very long time. I'll email you

@byardedwards @ycombinator @sklin_lite @LiYaoHuang2 Let's chat! Jeff.liu@finaldose.ai Love to get your view

FinalDose is building the first programmable drug platform - a single smart drug molecule that finds diseased cells by their DNA and destroys them. They're starting with all cancers. Congrats on the launch, @Jeffliu6068Liu, @sklin_lite, and @liyaohuang2! ycombinator.com/launches/QKj-f…

@ycombinator @Jeffliu6068Liu @sklin_lite @LiYaoHuang2 However, I think adequately targeting e.g. tumor cells vs normal cells in a living person is a very hard problem with these approaches. You need kinetic proofreading to increase fidelity. And you will need to hit several targets (no surprise there)

@ycombinator @Jeffliu6068Liu @sklin_lite @LiYaoHuang2 Recent article in Nature, also on Cas12a2 x.com/Bio_stations/s…

@JFPuget reminds me of Jim Simons's statement: "I wasn't the fastest guy in the world. I wouldn't have done well in an Olympiad or a math contest. But I like to ponder. And pondering things, just sort of thinking about it and thinking about it, turns out to be a pretty good approach"

Because solving high school level problems very quickly is not the same as advancing math.

@fromdevoid @tunguz Strongly agree. They are little labors of love in most cases.

@tunguz The whole collection is fantastic. A have 15 of those books. Highly recommend!

Excellent book, the best one on Gödel’s Theorem(s) that I’ve ever come across. It still requires a lot of deep thinking to get through, and I’ve not been able to follow all the arguments in detail. However, I’m confident that this is the first book where if I DID make the effort to understand all the arguments, I could do so. One or two more detailed reading could get me there. One overarching point that I got from reading this book is how much reasoning behind these arguments relies on “meta” mathematical thinking, and our ability to use human language to elucidate such concepts. Those who think that the ONLY way we can truly comprehend something is if we completely formulate it in code or mathematics are deluding themselves. As are those who think that “philosophical” considerations have become completely meaningless and redundant.

@MattZeitlin yep, society would collapse and the most valuable things would be food, potable water, guns, and bullets

the issue in a pandemic with that kind of mortality (especially if there was an outsize risk to children) wouldn't be getting people to comply with public health orders, it would be getting people to show up to work at municipal water treatment facilities

@unitedBananas88 @mikepat711 Open Tesla app, go to “location” in the navigate search box put in your destination. It will plot a route with charging stops. Can also do in car of course. I kept my ICE car for long trips but now that’s last situation I want to use it

@mikepat711 "You don’t have to look for charging." can you elaborate? I will take a 350 mile road trip soon. I've been trying to map out charger locations. will the car auto take you to a charge station as you get low? how does that work? thanks.

The two biggest things people ask me about my Tesla are: 1) Do you have problems charging it? 2) What do you do when you have to take long trips? I need you to understand this. I travel a lot by car. Long distances north/south/east/west through rural parts of every state, 500+ mile trips often. Teslas are WAY BETTER than any other car for road trips. Way better than any gas car, way better than any other EV. It is far EASIER, not harder, to road trip in a Tesla. You don’t have to look for charging. This is all done by software. You don’t have to plan stops. This is all done by software. You don’t have to drive or navigate. This is all done by software. You get into a Tesla, type or speak any destination anywhere, press “start self driving” on the screen, and that’s it. You’re done. The rest is all handled by software. You just have to sit there and enjoy the view. Zero stress, zero deciding which rest stop to stop at when you think your tanks gonna be low, zero worry about wrong turns, zero attention required to nav. Just kick back and take it in. It makes a 8 hour road trip feel like 2 hours, and you feel completely refreshed upon arrival, like you were sitting on your couch relaxing. No neck tension, no brain fatigue from keeping a car from crashing for 8 hours. It’s way better than any other vehicle for travel, not the opposite. I’m on a 600 mile work trip right now, and if someone told me I had to give up my Tesla and start traveling by ICE car again, I’d prob look for a new job. Seriously. It is way way better for travel.

MSK, MD Anderson, and every other major cancer center in the US takes traditional Medicare. Virtually every major hospital does. Medicare network is tip top. I know people who've travelled to Houston, Seattle, etc for cancer treatment. Sure they can afford a hotel and plane ticket but don't have to be fabulously wealthy for that.

@byardedwards @AppetitiveFruit the people flying into MGB/Dana Farber who do not live in the near vicinity are not your average medicare patient

in med school i spent a few weeks rotating at a top ICU in Germany it made me appreciate how strong clinical care is at major academic medical centers in the states the uncomfortable reality: US healthcare is best in the world if you ignore affordability

I realize you're addressing multiple issues but: ~20% of US has Medicare, which gives excellent care. ~55% have insurance through employment, which is usually very good as well. So >70% of Americans have excellent health insurance IMO. Should be 100%, but still. And ~8% uninsured, which is of course 8% too high.

@AppetitiveFruit I think for the top 1% (in income/access as well as in complexity of *medical* need — note, separating out the science from the care coordination/SDOH need), definitely the US For the average person, definitely not

@og_kulak @FOXNashville seriously. The day Waymos cause more traffic slowdowns than pedal taverns we can talk.

@FOXNashville The ultimate conspiracy.

Days after launch, Waymo vehicles block traffic at multiple Nashville intersections. Multiple drivers posted videos of driverless Waymo vehicles holding up traffic or stopping in intersections in Nashville, Saturday, five days after the company's launch in Music City. bit.ly/48GS8MV

@curiouswavefn Brevity is the soul of wit-- "More is different" is enough

This tweet seems to have gotten some spirited pushback, so I think it's important to clarify what I think Kauffman is saying here: starting from string theory or quarks, you could potentially derive human hearts as one of multiple events/artifacts in the universe of possibilities. But the *causal* relationship between the structure of the heart (its ability to pump blood) and its fundamental role in keeping organisms alive and therefore making the biosphere possible is an evolutionary accident. Physics *by itself* cannot capture this contingency. Perhaps we need to indicate the difference by saying "reduced to" vs "explained by".

Exactly. You could play this game forever- "I demand Waymo vs the entire spectrum of human drivers on this exact street, exact same traffic/weather, for 1B miles" etc. To make a decision you have to come up with a reasonable, measurable standard. Beyond that, not a bad idea for companies and regulators to look at specific scenarios and see how AVs do. I hope/assume they are doing things like that before approval.

It would be impractical to describe all the streets, roads highways and byways with the precision you’re imagining, but also the residential street is a harder task for the AV than 495 because it’s less predictable, so I think this cuts in the opposite direction from what you’re imagining

When people start retreating to non-standard metrics, I generally suspect they have tried, and failed, to come up with a reasonable argument

@UnleashedG23066 Just saw them at the Ryman. Was amazing. Appreciate him while we can.

"Ramble On" is 56 years old and Robert Plant just walked onto The Late Show and made it sound like he wrote it this morning.

(1) ludicrously simplistic attempt to stir heartstrings (re brother) (2) rest of movie ~one long fight seen, no actual story (3) absurd "solution" (4) completely predictable resolution of (1). Admittedly fast-forwarded through much b/c so bad, but wanted to see how they wrapped it up (poorly). There are surely hungry, talented writers in Hollywood hoping for a breakthrough- how does this garbage get made?

@EckhartsLadder It’s impressive that the movie made it to Netflix Maybe the worst fucking movie I have ever seen

Kinda surprised I didn't see more people talking about War Machine on here. I thought it would be slop, but really is just a competently made action movie. Gory, good action... very much like a 2026 Predator. The walker's design is also really cool.

Hoping there will be a trial project/proof of concept-- ?? a toll road that is autonomous vehicles only (including things like FSD). Probably in China. I expect (1) essentially perfect safety will be crystal clear and (2) everyone who uses it will want it. Once experienced it will be obvious that we should get there ASAP

@wholemars @KelseyTuoc and of course death isn't the only bad outcome-- people are paralyzed, brain damage, etc. Should be looking at all serious injuries avoided, not to mention total $$ due to accidents.

Because Waymo is rapidly scaling up its operations, we're rapidly accumulating more evidence on the question of whether it's safer than human drivers. The case for Waymo being safer than human drivers in in some sense almost twice as strong as it was in October.

@DistractedAnna @idobadtakes So, payor mix, employed vs not, and leverage to negotiate rates with insurers all factor in, and the differences are not small /end

@DistractedAnna @idobadtakes Also, esp in desirable locations, many physicians are employed, and so their pay isn't directly tied to how much they bill (the employer makes money off of them) and tends to be lower if the employer has a bunch of MDs who will take less to live there. /3

Every doctor knows we could double our income by going out to rural areas. We joke about it, talk about quitting the grind of the city to go be rich in rural Missouri or Wisconsin. No one actually does it