Christopher Steele

Proud and excited to receive a @DFF_raad grant for the startup of my translational renal cancer research group at @moma_dk #renalcancer

Thrilled to share our latest paper on #mutationalsignatures recently published in @CellGenomics 🙌 Thanks so much to everyone that made SigProfilerExtractor a reality, especially Ludmil, @mishugeb, Mark and @VangaraRaviteja. Check it out here: doi.org/10.1016/j.xgen…

*Communication is everything* In our latest work we found that histone-H3.3 mutation in the #bone dysregulates the communication between osteoclasts and osteoblasts driving giant cell #tumour of the bone. #celldeathdifferentiation @cddpress nature.com/articles/s4141…

I could not have done this without a @CRUKresearch travel grant, nor without the support of @NischalanP to pursue this line of research, or Ludmil Alexandrov for seeing the potential in the method! 2/2 nature.com/articles/s4158…

We have expanded our previous method of copy number signatures developed in sarcomas to identify a reference set of pan-cancer copy number signatures. These are available on @cosmic_sanger now! 1/2 nature.com/articles/s4158…

Topographies of more than 70 mutational signatures are now available on COSMIC mutational signatures database.

Super excited to share our opinion article @IMalanchi and @fcicca from @TheCrick on @TrendsCellBio. We aim to add a new perspective to cancer initiation by asking two simple questions: 1) How does a mutant cell gain tumorigenic potential? + cell.com/trends/cell-bi…

Our paper on #ctDNA in #osteosarcoma is out in European Journal of Cancer. Supported by @TomPrinceCT, @BCRT, @lundbeckfonden. Great collaboration with @NeeshaKara, Adrienne Flanagan, Solange De Noon, @StephanBeck6, @iusher3, @orthopoda and others. sciencedirect.com/science/articl…

@webassignsucks @daniela_witten You are giving me too many flashbacks (currents?)!

That’s nothing. I’m a statistician who does research and I’ve annoyed HUNDREDS of statisticians

@JavierHerrero7 Loess fit or similar might be a good idea. Could depend on the dataset though.

Hive mind question: When displaying a scatter plot to show the Spearman’s rank correlation, I think showing a linear fit is wrong, although I recognise it might be visually useful. Q: Shall the linear fit be displayed on the scatter plot or not?

Of g findaphd.com/signups/

If you are a data scientist (or just good at coding, machine learning, maths and stats) this is your chance to contribute to #COVID19 critical care! Help doctors find out what they can do to help maximise the survival rate of ICU patients? #datasaveslives

@arikaleph @elliebee Also, FYI, Washington State has a drop in cases on 17th March, not sure whats going on there!

My friend @elliebee and I built a little tool to track Coronavirus cases, both daily increases and in aggregate, by geography. It also features some experimental regression functionality. coronavirus.arik.io

@arikaleph @elliebee Love the resource, have been checking it regularly! Don't know if you are open to feature requests, but here goes anyway! When you select multiple countries on the line graph, it would be great to be able to to have separate lines for each country rather than summing them.

If you are interested in rare and fascinating cancers check out our review of the current knowledge of #undifferentiatedsarcoma of soft tissue. Come for shattered chromosomes, near-haploidy, hypermutation and extensive genome doubling! #TheLoneliestCancer authors.elsevier.com/c/1aj5-,Nm41B9…

@Henaree @Raspberry_Pi I had an Arduino back in the day, programmed it to turn on a little fan when it got hot...great for the heatwave!

My mate and I beat the heatwave by coding a @Raspberry_Pi to turn a light off and on at the push of a button

New paper out today in the Annals of Human Genetics from @UGI_at_UCL Professor @davecurtis314 "Clinical relevance of genome‐wide polygenic score may be less than claimed" tinyurl.com/y6zz97pu #ugi #ucl #polygenic #PRS

Our research on undifferentiated sarcoma is out today! Have a read to learn more about the genomics underlying this rare tumour type, including highly complex structural rearrangements, hypermutation, near-genome scale haploidy and more! authors.elsevier.com/sd/article/S15…

@CRUKresearch @NischalanP @TheCrick @sangerinstitute @uclcancer Thanks to @CRUKresearch for funding our work on this rare tumour type, and thanks to all the patients for donating their samples for research!

New #CRUKFunded research: Patients with previously unclassifiable undifferentiated sarcomas may be eligible for immune checkpoint blockade therapies, due to new methods to analyse whole genome sequencing @NischalanP @TheCrick @sangerinstitute @uclcancer cell.com/cancer-cell/fu…

@AndyFeber @JavierHerrero7 @NischalanP Thanks @AndyFeber and thanks for all the help in the course of getting the paper together!

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways sciencedirect.com/science/articl… Well done @cd_steele, @NischalanP & everyone else involved.