Casey Detrio

598 posts

Casey Detrio

Casey Detrio

@cdetrio

Katılım Aralık 2010
898 Takip Edilen1K Takipçiler
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Casey Detrio
Casey Detrio@cdetrio·
Was chatting with @josephch yesterday and he asked a great, but dreaded, question: how will the eth1 chain, all the existing eth1 contracts, and users fit into the eth2 roadmap (Serenity) long-term, as focus shifts to the eth2 launch?
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Steven Salzberg 💙💛
Steven Salzberg 💙💛@StevenSalzberg1·
Yet another major blow to the hypothesis that a microbiome of cancer exists. TLDR: the main results from a 2020 @ScienceMagazine paper claiming to find bacteria in breast cancer simply doesn't hold up. Well done @NFdeMiranda, Jacques Neefjes, et al
Noel F. de Miranda@NFdeMiranda

🔬In a bid to replicate a prior study, we couldn't confirm LPS presence within breast cancer cells. We did spot it around ducts & in macrophages, aligning with its biology. #ResearchReplication #Cancer #Microbiome biorxiv.org/content/10.110…

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Casey Detrio
Casey Detrio@cdetrio·
@Ryan_Mac_Phd @SaskiaPopescu @angie_rasmussen @KatherineJWu Can you elaborate on the right circumstances? I'm not finding any specific recs of where/when it'd be most useful to screen using rapid tests, versus diagnose using PCR. (Seems to be lost in the dunking from both sides - "PCR is too slow", "rapid tests are no silver bullet").
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Ryan McNamara 🧬
Ryan McNamara 🧬@Ryan_Mac_Phd·
@SaskiaPopescu @angie_rasmussen @KatherineJWu And for the inevitable mentions from the peanut gallery in response to this, I have long stated that rapid antigen tests can be very useful in the right circumstances. But to claim we can be out this is in a few weeks if we did mass rapid testing is just laughable.
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Dr. Saskia Popescu
Dr. Saskia Popescu@SaskiaPopescu·
There’s a lot to unpack here and I’m curious for opinions from Drs. @Ryan_Mac_Phd @angie_rasmussen - but I do find it interesting to try and call out an experienced science journalist while also promoting sensationalist tweets from armchair epis.
Intelligencer@intelligencer

Rapid antigen tests are effective, cheap, and could quash the pandemic within weeks (in theory). Harvard epidemiologist @michaelmina_lab spoke with @dwallacewells about their public-health potential nym.ag/36GCyBu

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jefflau.eth
jefflau.eth@Jefflau·
And two of the new blocks in the first 14 hours were proposed by a validator node I'm running! 🤓 Although maybe that isn't so historic...
Spencer Noon 🕛@spencernoon

Historic day for #Eth2 👨‍🚀 🏴‍☠️ ☑️ 900k $ETH deposited ☑️ $535 million locked ☑️ 166% of threshold ☑️ 2.7k unique depositors ☑️ 22k txs sent to contract h/t @DuneAnalytics @hagaetc

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Casey Detrio
Casey Detrio@cdetrio·
@SMBrocklehurst @Dereklowe Sitting casually in my armchair, if I may, I think the breakthrough here is not so much knowing the 3D structure of a target protein. But knowing the 3D structure of all the proteins.
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Simon Brocklehurst
Simon Brocklehurst@SMBrocklehurst·
@Dereklowe Yep. Far too many people pontificating today know nothing about what it takes to develop successful drugs. The truth is that knowing the 3D structure of the target is, in *general* (leaving aside niche technologies that require it) not important... or even particularly useful.
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Casey Detrio
Casey Detrio@cdetrio·
[2 years ago, paraphrasing]: "Perhaps in four years, if we assume that the trendline continues, and we have no real reason to believe that it will, at least not without new conceptual breakthroughs." Today: "Pretty much solved." "I think it's over." moalquraishi.wordpress.com/2018/12/09/alp…
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Casey Detrio
Casey Detrio@cdetrio·
2 years ago: "substantial progress [...] Great! Does this mean the problem is solved, or nearly so? The answer, right now, is no." ...
Mohammed AlQuraishi@MoAlQuraishi

CASP14 #s just came out and they’re astounding—DeepMind looks to have solved protein structure prediction. Median GDT_TS went from 68.5 (CASP13) to 92.4!!!! Cf. their 2nd best CASP13 struct scored 92.8 (out of 100). Median RMSD is 2.1Å. I think it's over predictioncenter.org/casp14/zscores…

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Casey Detrio
Casey Detrio@cdetrio·
@haydenzadams People think if most of the code is copy/pasted they don't really need an audit "Consensus is [it's] unnecessary other than to assuage [..] folks unfamiliar with the drag and drop contracts we are using." "We actually have very little custom code." forum.pickle.finance/t/code-contrac…
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Hayden Adams 🦄
Hayden Adams 🦄@haydenzadams·
It’s good to remember that “complicated” defi hacks are still super avoidable. Just requires putting a lot of love and effort into user security. Expensive audits help but are a red herring. The people best equipped to make a system secure are the devs who build it.
vasa@vasa_develop

Was in a 5h long late-night/early-morning war ⚔️ room where reverse engineering took place last night with @banteg @emilianobonassi @bneiluj @samczsun and the @picklefinance team One of the most intricate hacks till now in the ecosystem 🤯 Diagram showing the series of events👇

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Casey Detrio
Casey Detrio@cdetrio·
@dankrad @QwQiao If you can find two uncorrelated and volatile assets, a "volatility harvesting" strategy would be profitable (aka volatility pump or Shannon's demon), iiuc. Assets become (short-term) correlated b/c uncorrelated volatility is an arbitrage opportunity. thepfengineer.com/2016/04/25/reb…
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Dankrad Feist
Dankrad Feist@dankrad·
@QwQiao How about both just move according to current investor mood? When investors feel good, they like more risk. When they feel scared, get out of risk.
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Casey Detrio
Casey Detrio@cdetrio·
@peterontheblock @VitalikButerin Obfuscation would let you deploy "encrypted bytecode" that holds a privkey. We'd have wrapped BTC with no trust - the contract could sign BTC transactions using a privkey in obfuscated bytecode (despite being public bytecode, the privkey remains secret because it's obfuscated).
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Casey Detrio
Casey Detrio@cdetrio·
@peterontheblock @VitalikButerin WBTC (Wrapped BTC) is an erc20 backed 1:1 with Bitcoin held at Bitgo Trust, because you can't put a BTC privkey in an erc20 contract (well you could, but anyone could see the privkey in the deployed contract).
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Casey Detrio
Casey Detrio@cdetrio·
@jaybny @QWQiao Yes, it uses limit order books. With one weird trick (market makers hate it!) that makes it better than a continuous-time l.o.b. - batch matching - so your order may fill at a price *better* than your limit price.
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Ethan Buchman (🐝,🦇)
Ethan Buchman (🐝,🦇)@buchmanster·
@emrec90 IMHO, if it's all about speculation and arbitrage, yes. Connect it to real world local economics, then we're up to something good.
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Ethan Buchman (🐝,🦇)
Ethan Buchman (🐝,🦇)@buchmanster·
As I've been saying. Virtually all DeFi is rebuilding existing finance on slightly more transparent infra. So the risks are the same, it's just slightly more obvious how you get fucked. We need to build genuinely new bottom-up local systems or we're wasting our time.
Tarun Chitra@tarunchitra

Big Short 2.0: PoS and DeFi are mortgage-backed securities! @alexhevans & I tried to find grand unified theory for the financial derivatives hidden in PoS and DeFi ➡️ uncovered mathematical equiv. to MBSs. Why? Same payoffs and income inequality! 👇🏾 medium.com/gauntlet-netwo…

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Casey Detrio
Casey Detrio@cdetrio·
@WesPegden @jfeldman_epi @nataliexdean A society with "no lockdowns" might have worse economic disruption than one with lockdowns (if infections spread exponentially...). Also, "locking down" doesn't mean stop producing food. The UN warns of global food shortages due to tariffs and export bans, not social distancing.
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Wes Pegden
Wes Pegden@WesPegden·
@jfeldman_epi @nataliexdean I would really have expected a more critical take from someone studying "Epidemiology of social inequality and state violence". A ruling class locking down a society to protect themselves while the poor starve would be, literally, state violence motivated by social inequality.
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Casey Detrio
Casey Detrio@cdetrio·
@naval @kunalb11 Scale up testing, and open up for good (no risk of re-closing, ref. @paulmromer). Game of open-close green vs red zone whack-a-mole might not be any better than nationwide closure (voluntary or involuntary). Uncertainty of future status is what kills an economic restart.
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Naval
Naval@naval·
@kunalb11 The alternatives are mass death or economic collapse. Take your pick.
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Naval
Naval@naval·
The Swedish approach allows us to measure the cost of building herd immunity using partial and voluntary measures rather than a full shutdown. Drop your preconceived notions, ignore the narratives, and dispassionately track the data.
Naval tweet mediaNaval tweet media
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Keşfet

@ScienceMagazine @NFdeMiranda @Ryan_Mac_Phd @SaskiaPopescu @angie_rasmussen @KatherineJWu @jefflau @ChihChengLiang