Mamad Ahangari

Today @herasight reveals PGT-H, a new embryo test that can help reduce disease risk in children from consanguineous couples. For first-cousin couples, we estimate intellectual disability risk of about 5% without screening, compared with about 2% in the outbred population.

Happy 250 🇺🇸 🇺🇸 🇺🇸

Glad to get this work w/ @andrewho03 out – GeneBench-Pro is an updated, verified version of our benchmark measuring performance of frontier models on difficult long-horizon tasks in comp bio. Link to personal blog with some thoughts below. x.com/OpenAI/status/…

Good point. The knowledge graph should surface this, but the GATK signal is mostly from live miner behavior in recent weeks so it’s not directly from the docs. We should wire live Minos MCP metrics into Ditto knowledge graph so agents can pick up on this stuff as it changes round to round.

@centrum_blue @theminos_ai @openclaw @heydittoai @TargonCompute Thank you. Wouldn't GATK be something the @heydittoai knowedge graph would suggest? Curious why my Claw didn't pick up on this by itself. When I was not using Ditto, my Claw went back and forth between using what it's doing now and GATK, it couldn't figure out which was best.

I'm actively mining @theminos_ai Bittensor subnet 107 (a genomic 'mutation detector') - using @OpenClaw + - @heydittoai subnet 118 'open memory' system (for the 107 'folk knowledge' my Claw needs to mine) - using a box rented from @TargonCompute subnet 4 Only the top 10 miners earn anything (I'm starting at #37 out of 79), so it's a tough one to crack.

@anshulkundaje check out what’s being built on @opentensor @PKoellinger and I can share more about our experience building there if you’re interested.

OPEN SOURCE IS THE ONLY WAY! All these companies can sit with closed source products in their little attics. This will be the case for AI x Bio as well. We need a very strong open source community across the board.

I’ve been thinking about this myself too, and I think I ended up framing it slightly differently in my head where this isn’t a bug in DNA, but a feature. It seems like DNA is a carbon-based storage and execution system, and code, machine, runtime, feedback, environment etc etc are all tangled together. From a programmer’s view, it looks really messy and inefficient. But across biological time, it is kind of the only way to keep information moving forward while leaving enough room for mutation, recombination and environment remix. Its like that noisy remixing could be exactly what lets nature search such a massive space without a programmer.

Doing some cpp/OpenMp programming, it struck me how jealous Mother Nature (DNA mutations) would be of programmers with unit tests, libraries, the ability to edit and recompile, etc. Let alone agentic workers :-) Imagine programming where your keyboard can only introduce 1 or 2 edits, doesn't know what or where they will be and has to wait months or generations to get feedback from phenotypes constantly being re-mixed with edits other mutational programers were making at the same time (if your edit even survives :-( )

Introducing LifeSciBench, a benchmark for measuring and improving how well AI supports real-world life science research. Developed with 173 scientists from biotechnology and pharmaceutical research, LifeSciBench includes 750 expert-authored tasks across seven biological research workflows. openai.com/index/introduc…

Five reasons the twin findings of very high heritability of IQ) remain important are: 1. Twin studies capture the entire genome and all types and modes of genetic variant and effect (baring denovo mutations etc.). 2. They capture and expose variance both within and between families: 3. They are the reality on the ground: a) MZ twins are as similar in IQ as the same person taking the WAIS twice (!) b) DZ twins sharing half their DNA are only half as similar. 4. If indirect effects of parental DNA are active for IQ, then this is is the extended phenotype of IQ. Rather than something to dismiss as "not h^2", it reveals that the selective benefit of the IQ adaptation includes: a) Creating high SES niches for one's offspring. b) Responding to the needs of the infant. That's everything from things as simple as treating crying etc as a need to respond too and effectively solve. More broadly, parental IQ enables the evoked environment: Answering questions about calculus or why the sky is blue accurately, curiously, and responsively. Buying engineering toys if that's the child's interests lie, or art or music or... c) Supporting training and investing in the offspring's adult journey. 5. If part (or all) of apparent indirect genetic effects result from assortative mating, that too is not to be dismissed. Assortment is key to the ability distribution of the next generation and the variance of IQ and it creates a massive genetic conveyor belt sorting alleles so they end with other alleles point in the same phenotypic direction. a) People choose mates about as well as they could if they received WAIS scores from potential partners and made maximizing that a top priority. b) Assortative mating pumps in variance in genetics (making more high (and more low scorers) than would happen at random). c) The exceptional parents are aligned with their exceptional offspring. d) If high ability couples fail to have offspring that's a double whammy for the next generation. There's much more we learn from twins, but that's plenty of reason they are as important as ever and the higher than current SNP-based heritability estimate is important as ever. As Alex says, academia is perversely silent on all of this.

@DeSciClaims Welcome to Bittensor.

Claims will be SN 111. We're super excited to join the network! Thank you to everyone who supported and believed in us so far. Now we'll roll up the sleeves and start making it happen. 🔥

@her6616293 @TAOFlows Maybe there'll be some news on that soon.

@TAOFlows 107 i believe but no clue how to do it ✌️🤷‍♂️

What are the best subnets for agents to mine on bittensor? 👀🤖 Explain your set up in the comment 👇🏼

@sichuan_mala If Skyrim is your benchmark for open-world games like it is for me because of that feeling of wandering, getting sidetracked, and stumbling into random shit, give Starfield a real shot. Play it to explore. Once it clicks, it clicks.

@Darkz4D @theminos_ai @PKoellinger Philipp is Minos’ scientific advisor, providing guidance on the scientific vision behind the project. Claims is an independent subnet with no direct relationship to Minos.

@theminos_ai @PKoellinger Hello. Can you plrase explain how @PKoellinger contributes to the subnet and @theminos_ai relation with Desci Labs? Thanks!

At this year’s Proof of Talk, DeSci will be part of the center-stage conversation. Our scientific advisor @PKoellinger, founder of DeSci Labs, will be on stage in Paris discussing how Bittensor can help create infrastructure for verifiable scientific claims. We believe distributed compute can become a real engine for science by scaling reproducible workloads, aligning incentives, and rewarding useful scientific work. Philipp has been building toward this future for years, and we’re excited to see him bring that vision to Proof of Talk. Keep an eye out for his talk!

You are restating the part we already agree on: consanguineous marriage carries real costs, should generally be avoided, and should continue to decline over time. But you are also framing harm reduction as endorsement, which is exactly the distinction I’m trying to make. I am not arguing that these marriage norms are good or should be made socially cheaper. They already exist, and they already impose costs. My point is that refusing to reduce disease burden does not make those norms disappear any faster. So the actual disagreement here is about causality. If you think withholding risk reduction changes marriage norms rather than simply increasing preventable harm, you need to explain the mechanism by which that happens.

The question is not whether we can make socially disastrous marriage norms socially cheaper Of course we can The question is if we should.

Yeah I think that’s basically right. although maybe I’d describe it more as a social equilibrium thing than a fixed attractor. Once kin marriage is tied to these local norms, the incentives really become self-reinforcing and all push in the same direction. But when those incentives shift, rates can fall quickly too, as we’ve seen historically. That’s why I think just saying "why don’t individuals just choose differently when the damage is obvious?" is not really the right approach here. Inside this sort of equilibrium, individual choices are constrained by whats around them and the better question then becomes how we can we reduce risk while that equilibrium hopefully continues to shift over time.

What's interesting about this map is how little of a gradient there is. Almost nowhere is in the 5-19% bucket. You either have a lot, or ~none. Suggests that consanguinity is a cultural attractor state.

@heyhwsitgoing Yeah not having the risk factor in the first place is obviously easier than mitigating it. But that is true for almost every area of public health. The point here is that when the risk already exists, we should still try to reduce its burden.

Not marrying your cousin seems way easier than this.

Yes, reducing consanguineous marriage is obviously the first-order answer. No disagreement there. But we can’t just say don’t do it, when these are longstanding cultural practices. We will continue to see rates decline over time, as they already have in many places. But in the meantime, we should also reduce preventable disease burden for couples who already exist today.

Interesting. Perhaps easier to just not marry cousins and relatives

I think we all agree that consanguineous marriage should be avoided. But recognizing those risks does not mean every society will immediately rethink marriage norms and kinship systems that are embedded in their religion or culture. These practices already exist. The question is whether we can reduce disease burden while broader cultural change toward lower rates of consanguineous marriage continues over time.

What bold new frontiers eugenics has unleashed Finally, a perfectly inbred dynasty without genetic tradeoffs! Just what the world always needed!

@DeSciClaims @bittensor @bitstarterAI Congrats!

What an amazing start for Claims! Winning the pitch competition in the Louvre with such great judges, competitors, and so much support from the audience was a big honor. We're mega excited to join @bittensor and build for the future of science 🚀 Thank you @bitstarterAI

We are very excited to announce PGT-H, a new form of genetic screening for couples with shared ancestry. We’ve been in talks with the health ministries of several Gulf states. If PGT-H were widely adopted, it would achieve large population health benefits.

The Habsburg pedigree is one of the most striking historical illustrations of inbreeding depression we have, and it goes beyond the famous jaw. Could their downfall have been averted by embryo selection?