chatrin

The first paper from my PhD is out @ScienceAdvances! It's a tale of two #PTMs brought together by Deltex E3. Deltex surprisingly binds #NAD and modifies #ubiquitin tail with #ADPribose. This inactivates Ub, but is readily reversed by deubiquitinases. (1/3) advances.sciencemag.org/content/6/38/e…

Congratulations to the Poster Award winners #EMBOubiquitin24: Jason Collins from ⁦@werner_achim⁩ Kai Gallant from ⁦@MalteGersch⁩ and Chatrin Chatrin from ⁦@IvanAhelLab⁩ Well done! 👏💫🏆 ⁦@YKulathu⁩ ⁦@polosimona1⁩ ⁦@LabJoazeiro⁩

It has been an honour to host @UniofOxford's @chatrin_ch on her Scotland 🏴󠁧󠁢󠁳󠁣󠁴󠁿 tour's 1st stop in Dundee. We had many activities and reunited @CRUK_SI alumni @IPuoti and Helge. Very exciting work on #ubiquitin ADP-ribose from her PhD & postdoc work. Nice late night walk on the sea cliffs with @KevinHaubrich1

We uncovered how UBE2K extends K48-linked #ubiquitin in @nchembio with our @CRUK_BI team (@gazsib), @UoGBioPhys (@maxgabro), and @BrianOSmith1967 using integrated structural biology 🧲#NMR & 💎 #Xray: rdcu.be/cEV5f #openaccess

@AnhHLe2702 @mayor_lab @BristolBiochem Congratulations, Anh!!

@vBarthet @IPuoti @ChelseaGerada1 Congratulations, Valentin!!

Graduation day today! Officially Dr. Valentin J. A. Barthet 👨🏻‍🎓 #UofGGrad21

@mediocre_jake @ScienceAdvances It's not too late to start now 😉

The first paper from my PhD is out @ScienceAdvances! It's a tale of two #PTMs brought together by Deltex E3. Deltex surprisingly binds #NAD and modifies #ubiquitin tail with #ADPribose. This inactivates Ub, but is readily reversed by deubiquitinases. (1/3) advances.sciencemag.org/content/6/38/e…

@vwang93 I enjoyed reading your take on the books. Might try to read Kuhn 🤓

@AnhHLe2702 Congratulations! 🎊🎉

No 🚰🚿

1/13 COVID-19 had a significant impact on our research activity but our researchers adapted brilliantly and work @CRUK_BI continued to thrive. This #WorldCancerDay #WCD2021 , we're highlighting just some of the successes from the past year:

Creative approach to switch CAR T cells on/off! Achieved through CRBN-degron interaction induced by lenalidomide. Cool system.

@AnhHLe2702 I see facial features 😯

Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states biorxiv.org/cgi/content/sh… #biorxiv_cellbio

😮 ‘The game has changed.’ AI triumphs at solving protein structures sciencemag.org/news/2020/11/g…

@MSuskiewicz @maxgabro @Mark_A_Nakasone @ferojahmed @gazsib @DSumpton @BrianOSmith1967 @CRUK_BI @UofGMVLS Thank you! It took us by surprise as well 🙂

@chatrin_ch @maxgabro @Mark_A_Nakasone @ferojahmed @gazsib @DSumpton @BrianOSmith1967 @CRUK_BI @UofGMVLS A very interesting study. After reading Yang et al.'s paper, I was sure NAD+ would be bound by PARP9 -- but it turns out that isn't the case. Congratulations!

@jnpruneda We're excited about this too! Thanks for sharing :)

A really cool twist on a RING E3 ligase that actually temporarily inactivates ubiquitin! advances.sciencemag.org/content/6/38/e…

Thanks to @maxgabro @Mark_A_Nakasone @ferojahmed @gazsib @DSumpton @BrianOSmith1967, twitterless Lori and Danny for their contributions. I am also grateful to @CRUK_BI for sponsoring and hosting my PhD, it's a great place to do science. @UofGMVLS (3/3)

#PTMs are like codes that are branded onto a target protein. The codes are read by dedicated "readers", which can change a protein's cellular fate. Ub itself is a protein, so it can be modified by other small PTMs - and we have a brand new code! (2/3)