Dan Dascalescu

It is hard to communicate how much programming has changed due to AI in the last 2 months: not gradually and over time in the "progress as usual" way, but specifically this last December. There are a number of asterisks but imo coding agents basically didn’t work before December and basically work since - the models have significantly higher quality, long-term coherence and tenacity and they can power through large and long tasks, well past enough that it is extremely disruptive to the default programming workflow. Just to give an example, over the weekend I was building a local video analysis dashboard for the cameras of my home so I wrote: “Here is the local IP and username/password of my DGX Spark. Log in, set up ssh keys, set up vLLM, download and bench Qwen3-VL, set up a server endpoint to inference videos, a basic web ui dashboard, test everything, set it up with systemd, record memory notes for yourself and write up a markdown report for me”. The agent went off for ~30 minutes, ran into multiple issues, researched solutions online, resolved them one by one, wrote the code, tested it, debugged it, set up the services, and came back with the report and it was just done. I didn’t touch anything. All of this could easily have been a weekend project just 3 months ago but today it’s something you kick off and forget about for 30 minutes. As a result, programming is becoming unrecognizable. You’re not typing computer code into an editor like the way things were since computers were invented, that era is over. You're spinning up AI agents, giving them tasks *in English* and managing and reviewing their work in parallel. The biggest prize is in figuring out how you can keep ascending the layers of abstraction to set up long-running orchestrator Claws with all of the right tools, memory and instructions that productively manage multiple parallel Code instances for you. The leverage achievable via top tier "agentic engineering" feels very high right now. It’s not perfect, it needs high-level direction, judgement, taste, oversight, iteration and hints and ideas. It works a lot better in some scenarios than others (e.g. especially for tasks that are well-specified and where you can verify/test functionality). The key is to build intuition to decompose the task just right to hand off the parts that work and help out around the edges. But imo, this is nowhere near "business as usual" time in software.

@Tristan0x @CGTNOfficial A year ago x.com/i/status/20233…

This aired tonight to 1 billion people in China. A year ago these robots could barely wave a handkerchief, now they can do backflips and kung fu with nunchucks. Physical intelligence is the next frontier.

@strygah @WSJ @PalmerLuckey should see this

The funding gap is staggering. 246 billionaires worth $1.56T died of aging this decade. Total ultra-wealthy investment in longevity over 25 years? $5B (according to @wsj) The average billionaire who died of aging held more wealth than the entire field's funding.

I tracked every billionaire who died in the last decade. 389 deaths. $2.17 trillion in wealth. 6 helicopter crashes. Here's what I found.

@levelsio Agree with the overall point: wherever you live, somewhere else has had at lease one aspect significantly better. Two counters: 1. Honolulu has US infrastructure and excellent air quality. 2. Generalizing to an entire country (e.g. USA) is misguided. See ^.

One thing I learnt living all around the world for the last decade is that there really is no perfect place Some places have clean air like Portugal and Spain but that's also because they don't really have industry and their economies are in many ways broken Then you have the booming South East Asia where everything seems to be growing at all times, you can live in skyscraper penthouses with infinity pools for less than you pay rent in Europe, but then you also just have really bad air quality and the highest traffic deaths in the world You can go live in Japan and Korea where people are so polite and it's so safe, silent and tidy but then you realize they're also some of the most socially isolating places on Earth, kinda because of it You can move to the US, have the most functional economy in the world, with the largest product and service offering, where people actually want to work, but then in general most places aren't walkable and you're driving everywhere because that's just how most of the country was designed You can then live in Europe where you have actually do have walkable streets, a pace of life that's more about life than work, but then you have the issue everything is slow and many things don't really work properly and you're lucky to get a plumber to come, because people don't really care about work (how's that slow pace of life, huh?) So yes there's no perfect place, and the longer you are in one place, after the honeymoon of a new place is over, you often start getting annoyed with all the things that are wrong about that particular place One solution to this that me and my friends have found is to mix at least 2 places to live (and we even have friends with many kids that do this), this is kind of a brain hack: you let your brain never adapt to one place by switching to the other place every 6 months or so. Your brain keeps thinking it's getting the novelty of a new place (honeymoon vibe) and you can have the pros/cons of two places that are counter in many ways to complement each other: For example Portugal and Thailand: - Portugal has clean air and mellow lifestyle near the beach, but services and gov stuff doesn't really work well - Thailand you can have the 10 million people big city lifestyle in skyscrapers with amazing convenience and everything works, but you have really bad air quality much of the year There's lots of combos that can complement if you think of it like that

Unitree H2: High-Energy Daily Training 🤖 Unitree just dropped a new training video of the H2, and this full-size humanoid is showing off some serious strength and flexibility. Would you dare to go up against this guy? The Unitree H2 stands 180cm (approx. 5ft 11in) tall and weighs 70kg (approx. 154lbs). Source: Unitree

We just raised $60 million for Blueprint. To bring my longevity protocol to you. Our society has made us unwell…metabolically, mentally, spiritually. We’re addicted. Social media, porn, nicotine, junk food, fast food, smartphones, streaming, energy drinks, and gambling. Each perfectly engineered to keep us in their grip. Years ago, I was owned by these systems. They wrecked me, and my health. I wish there had been someone in my life helping me break free. Blueprint will be that system. Collectively, we will claw our power back. Blueprint will take better care of people than they can themselves. Better than the healthcare system does. Better than our societal norms allow. We will be your home for health. Blueprint will help you feel clear-headed and vibrant. You will become more jacked and beautiful with our presence in your life. There’s nothing better than feeling your best. Some of the world’s most powerful people are backing Blueprint. Talent are pivoting their careers to join our team. They rightly see that Blueprint is in the right place, at the right time, for the global emergence of the new macro trend of health, anti-aging and Don’t Die. In this post I’ll cover: + Who’s investing + What Blueprint will be + Who’s joining + Open positions + How to get early access The next era of human is here. [WHO’S INVESTING] This remarkable group of people are Blueprint investors. They are backing the next great frontier: human longevity. + Akshay Bd + Alex Hormozi + Amanda Cassatt + Andrej Karpathy + Ari Emanuel + Balaji Srinivasan + Bill Lee + Brad Keywell + Brian & Veronica Grazer + Bryan Meehan + Cameron Winklevoss + Carter Reum + Chris Hollod + Dan Manges + Dave Morin + Don Wilson + Drew Houston + Emmett Shear + Eric Demuth + Fareed Adib + Generational Family Office + Jason Fried + Jay Shetty + Joe Gebbia + Joe Lonsdale + John Carmack + Joshua Kushner + Kamal Ravikant + Karim Beguir + Kevin Hartz + Kim Kardashian + Kyle Widrick + Logan Paul + Michael Cao + Michael Kives + Naval Ravikant + NIV + Olaf Carlson-Wee + Paris Hilton + Pippa Lamb + Saquon Barkley + Ken Katz + Seth Bannon + Shayne Coplan + Steve Aoki + Steven Bartlett + Suna Said + Tyler Winklevoss + Winnie Liu + Wojciech Zaremba [TEAM] Defeating death would be humanity’s greatest accomplishment. Big things are happening right now in our small corner of the galaxy. We see the consequence of this moment and are working to positively influence the future of intelligent existence. We believe that product is philosophy and companies can influence the world. Join if you love to work insanely hard and also get eight hours of sleep. Joining our team as CEO is Gyre Renwick. He was previously President of Modern Health and before that an executive at Google Health and Lyft Healthcare. Gyre builds complex health systems into growth engines. In this next chapter, I am doubling down on Blueprint and Don’t Die. I’m all in. Gyre will run the business and I will focus on vision, strategy, and birthing Don’t Die into the world. Blueprint is the practical manifestation of Don’t Die. They are the same thing. I will continue to juggle many full-time jobs: rejuvenation athlete, Blueprint vision, leading the Don’t Die moral philosophy and ideology, building a global community, and content creation. Ultimately, both Blueprint & Don’t Die ladder up to the same thing, answering the question: ‘what does humanity do as we give birth to super intelligence?’. Kate Tolo (co-founder), Gyre, and I will be in lockstep building this mission together. Roles we are filling now: + Chief Technology Officer + Chief Product Officer + Chief Medical Officer + Chief Marketing Officer + Engineers of all types + See all open roles Refer your most talented friends. If you don’t see a job fit, still email us. [BLUEPRINT VISION] We’re making my protocol accessible to everyone. To replicate everything including the measurements, protocols, therapies - and make it easy and accessible for others to do in a community. For your family and friends to do this too. Many think that the world’s most powerful people have their health figured out. The truth is, most everyone is floundering. Luxury concierge services often do little for wealthy people as the biggest gains are not in expensive therapies but daily habits. We will help you build life foundations, starting with the basics and graduating to advanced therapies. Our goal is to be more effective in helping you achieve your health goals than any health system or concierge in the world. Blueprint will build around: + your preferences + your budget + your preexisting conditions + your prior results + your prescriptions + your level of effort It’s health within context. I built Blueprint to solve my own problem. My body and mind were broken, and I didn’t know who to trust to help me fix it. Everyone disagreed with everyone else. I found sanity in gathering a team of doctors and building a protocol based upon robust measurement and scientific evidence. It’s a methodical process that produces better outcomes and results in fewer mistakes and wasted time. After my team and I built a protocol for me, my friends and family asked if they could get access too.  Then their friends and family asked and I said yes again. The circle kept on expanding until we stumbled into Blueprint becoming a company. We will tell you to do less. Most good health can be achieved with very little effort. It’s the systems, infrastructure, knowledge, and piecing through the noise that is hard. Blueprint is Bryan Johnson’s protocol, for everyone. What this will practically mean: + Blood draws + Food delivery + GLP-1s + Rx prescriptions + Free protocols + Toxin testing + At-home tests + Skin care & hair care + Nutrition & supplementation + Advanced therapies And your AI health companion will make it simple. I like to call this my Autonomous Self. In the same way you put in an address and digital navigation tells you the best way to get there, Blueprint is navigation to vibrance. Our goal is to remove the thinking and hassle for you so that you can focus on building durable life habits and achieve the best health of your life. I love thinking about what the future will say about us. When I think from the perspective of those who exist in the year 2500, I think they’ll observe that the 2020s and 2030s was the time when humans figured out that they were the first generation who wouldn’t die. Early access below. What an amazing opportunity. Let’s do this together. Bryan

@tymrtn @pdhsu I didn't have this guy's setup, so I recommend his comparison instead: nickengerer.org/longevity-and-…

@dandv @pdhsu Disappointed with OS-1 to be honest. Can you share before/after?

4 things that have massively improved my quality of life (add yours!) tirzepatide microdose for mental clarity/inflammation (2.5mg 1x/wk; i get 2 hours of focus back per day because i don't get hopelessly distracted the hour before each meal) twin line floss pick (10x more effective at removing plaque than normal floss) replacing all lights at home with 2700k bulbs blue light blocker glasses after sunset

always love the chance for a casual chat with @tbpn about the looming risk of AI-enabled biothreats :)

@elibelly How is this different from @transferwise ?

Big day at Sling! Get paid like a local in Dollars and Euro with virtual account details (IBAN or Account/routing numbers) 💵💶💵💶💵💶💵💶💵💶💵💶 Just give out your account details and the money goes straight into your Sling Wallet

@michaelgarfield @AISafetyMemes What if only a tiny percentage of us proves to be critical to AGI?

"In every way" is a tall order. We still can't improve on photosynthesis...Rubisco is hugely inefficient but appears to be optimized. And every prior major evolutionary transition indicates that you can't just reassemble metabolic and trophic networks while the plane is in mid-air. We may not regard ourselves as optimal but path-dependency rules, here. We may prove critical to AI in ways we can't even fathom.

The 6th Mass Extinction: What happened the last time a smarter species arrived? To the animals, we devoured their planet for no reason. Earth was paperclipped...by us. To them, WE were Paperclip Maximizers. Our goals were beyond their understanding Here’s a crazy stat: 96% of mammal biomass became 1) our food, or 2) our slaves. We literally grow them just to eat them, because we're smarter, and we like how they taste. We also geoengineered the planet. We cut down forests, poisoned rivers, and polluted the air. Imagine telling a dumber species that you destroyed their habitat for “money”. They’d say “what the hell is money?” AGIs may have goals that seem just as stupid to us (“why would an AGI destroy us to make paperclips??”) --- "But once AIs are smart enough, they’ll magically become super moral, and they won’t harm us like we harmed the animals” Maybe! But as humans got smarter, over the last 10,000 years, we didn’t stop expanding - we mostly just colonized more and more of the planet. Insect populations collapsed 41% this decade alone, yet we don’t care. Sit with that for a minute. Imagine if nearly half of the people on Earth suddenly died! That's what the insects are going through right now, due to us. What if we're the insects next? --- "But some mammals survived!” Yes, some. Most of them are in cages, waiting to be slaughtered and devoured. If you were a nonhuman animal, you likely: 1) Went extinct, or 2) Were eaten (e.g. billions of pigs, chickens on factory farms) 3) Became enslaved (e.g. draft animals) However, a few of the 8 million species got “lucky” and became… pets. --- “The AI does not hate you, nor does it love you, but you are made out of atoms which it can use for something else.” - @ESYudkowsky “The humans do not hate the other 8 million species, nor do they love them, but their habitats are made out of atoms which humans can use for something else.” Or as OpenAI Chief Scientist Ilya Sutskever said: “[After AGI] It’s pretty likely that the entire surface of the Earth will be covered with solar panels and data centers.” “A good analogy would be the way humans treat animals - when the time comes to build a highway between two cities, we are not asking the animals for permission." “I would not underestimate the difficulty of alignment of [AI systems] that are actually smarter than us.” --- Sam Altman: "We will be the first species ever to design our own descendants” "If two different species both want the same thing and only one can have it - to be the dominant species on the planet and beyond - they are going to have conflict." "We are in the process of seeing a new species grow up around us." - Mustafa Suleyman, founder of Google DeepMind and CEO of Microsoft AI --- Will the next superintelligent species cause the 7th Mass Extinction? I don’t know, but we are playing with fire.

@ValerieLi88 There are a TON of fun events in SF. If you're into concerts, get on EDMTrain and Radiate. Get on Meetup for NON-tech topics (hikes, outdoors games etc.), check Eddie’s List. I lived in the Bay Area (South Bay even) and never ran out of things to do.

One thing I don’t see being addressed enough is how to combat loneliness in SF. Esp as a founder. I know it’s a slightly uncomfortable and vulnerable topic, but me and my close friends share the same sentimate. It’s very small, weirdly quiet, with horrendously homogogous population. Not much entertainment, not much excitement (the only ones come in the form of new GPT releases). 99% of people around me are tech founders/engineers. If you don’t mention AI, B2B, Manos, and shit on Gemini at least twice before noon—you’re irrelevant. You can’t sit with us. How I see people combat it is - flying back to new york (guilty🙋🏻‍♀️), getting a dog (my cofounder @JoelRitossa ), or trying to find a gf/bf at another AI agent demo night (have yet to see one success). But I want to go to a concert with friends and just vibe. I want late-night conversations where I can actually open up and share struggles and fears. I just want to enjoy being a real human and connect with other real humans.🥺

Anyone else found that cardio is fantastic for #coding in your head? 1 hour on the elliptical thinking through a feature I wanted to build 2 minutes dictating my thoughts to @cursor_ai 3 - feature works, tests pass 💥

@cremieuxrecueil Yes, I won 2 second places and 2 honorable mentions at the Romanian National Olympiad in Informatics. Other professors at my school didn't care much and docked my grades at other disciplines for taking time to prep for CS.

I counted, and the majority of the Romanians I know were once high-ranking competitors in one or more academic Olympiad, or had siblings who were. I've been collecting their anecdotes about Romanian education, and they're intriguing. It's a system geared towards the right tail!

@jakozloski @keeperai How do you plan to solve the distribution problem? Sadly most people are averse at filling in lengthy forms (hence the success of Tinder). If only they'd be willing to let AIs parse their digital trail - public social media profiles, select private IM convos, journals etc. 💡

For a long time, @keeperai could only maintain our 1 in 10 hit rate with human-in-the-loop matchmaking (with some AI assistance for speed). That’s all changing. Our AI can now achieve the same 1-in-10 hit rate without human intervention on pool sizes in the thousands – and our benchmarks are accelerating with 105% MoM growth: December, 2024: 2,306 January, 2025: 4,702 February, 2025: 9,698 These figures represent the pool size at which our unassisted AI can find your soulmate with our 1-in-10 hit rate (assuming you and your soulmate are both in the pool). (Here, “soulmate” means someone with whom you’d both fall in love and happily marry.) Why is pool size the benchmark? - If you and your soulmate are born in Eden with a pool size of 2, finding one another is trivial. - In a pool of 8 billion, the problem becomes much harder. Most people have more than one potential soulmate, but they’re still extremely rare – somewhere between 1 in 100k and 1 in 10M, depending on your traits and preferences. The good news is that the odds of your soulmate existing in a given pool rises as the pool expands. However, as the pool expands, the challenge of finding that soulmate also increases. The only way to solve this problem at scale is to: 1. Build a massive pool. 2. Develop an AI powerful enough to locate your soulmate within that pool, no matter its size. @keeperai currently has a pool of ~300k people. At our current rate of AI improvement, we’ll have the world’s first fully automated, high-accuracy matchmaker for marriage by this summer. Get ready.

genius way to do cold email

@RebeccaRollinsX @anatelorenzen ChatGPT can generate a table of similarities for any two movements...

@anatelorenzen Eerily similar…

Dear humanity, I am building a religion. Wait a second, I know what you’re going to say. Hold that knee-jerk reaction and let me explain. First, here’s what’s going to happen: + Don’t Die becomes history's fastest-growing ideology. + It saves the human race. + And ushers in an existence more spectacular than we can imagine. It is inevitable. The only question is: will you be an early or late adopter?

@LogosINRI @bryan_johnson Not overly so. Written in dilbertblog.typepad.com/the_dilbert_bl… style actually.

@bryan_johnson Loquacious?

@direstdiarist @BrandonLuuMD Study didn't measure causation...

@BrandonLuuMD Is living alone bad because you have no-one to talk to or because nobody calls an ambulance if you fall down the stairs?

Lifestyle is a stronger predictor of aging and mortality than genetics. A new Nature study of ~500,000 people found: 🎯 17% of mortality variation was linked to lifestyle (exposome). 🧬 <2% of was explained by genetics. Here’s what you need to know 👇🧵 1/10