Derek Brand

📢 M&A News: $GRTX to Merge w/ Obsidian Therapeutics Deal Terms » All-stock merger; combined company to operate as Obsidian Therapeutics » Concurrent $350M PIPE financing » Pro forma ownership: Obsidian ~53.2% | PIPE ~45.0% | Galera ~1.8% Lead Asset » OBX-115 (engineered autologous TIL therapy) » Indications: advanced melanoma + NSCLC » Stage: Ph2 melanoma | Ph1 NSCLC Clinical Signal » Designed with regulatable mbIL15 » May avoid high-dose IL-2 & support outpatient admin. » Built from minimally invasive core needle biopsy tissue Strategic Fit » Creates a solid tumor-focused engineered TIL company » Funded through key 2027 clinical milestones Timeline » NSCLC Ph1 data: 1H 2027 » Melanoma registration-enabling topline data: YE 2027 » Expected close: Q3 2026

Medvi—the first AI-enabled one-person unicorn—looks to be fraudulent. Incredible.

We used AI to predict the failure of a Phase 3 trial before the results were announced. Today, we're publishing 10 more predictions for the future. Thread 🧵

We used AI to predict the failure of a Phase 3 trial before the results were announced. Today, we're publishing 10 more predictions for the future. Thread 🧵

We believe that superhuman clinical trial forecasting is the critical bottleneck to curing all diseases. AI may compress a century of biological discovery into a decade, but if we don’t fix the broken clinical trial ecosystem, very few of those discoveries will make it to patients.

GLP-1 drugs are the ultimate validation of the techno-solutionist approach to society's most challenging problems. The obesity crisis seemed liked it would just get worse and worse forever. Scolding from public health officials didn't work. Proposals to completely overhaul our food systems were dead on arrival. Instead, we invented a weekly shot (based on Gila monster venom!) that fixes obesity directly. And now, thanks to the economic incentives in our biomedical industry, we have follow-on drugs that will be cheaper, even more effective, and easier to administer (by taking a pill instead of a shot). Policymakers should be focused on figuring out how we can get more breakthrough drugs like GLP-1s (and faster). They also should think hard about which slopulist ideas might inadvertently kill the goose that lays the golden eggs.

To: Admitted Students on Ivy Decision Day From: UATX Congratulations. Getting in was hard and you should be proud. Now here’s some unsolicited advice so you don’t waste the next four years. Go to class. We know this sounds obvious. But as the New York Times reported recently, Harvard students routinely skip class, rarely speak up when they're there, and focus on their devices instead of the discussion. Faculty say few students do enough preparation to contribute meaningfully. The average college student spends about 20 hours a week on class and studying combined. At UATX, we aim for 50. That’s the difference between a part-time commitment and a full-time job. You (or your parents) are about to spend upwards of $90K a year. If you don't show up, you're paying roughly $250 per skipped lecture for the privilege of sleeping in. Read the books yourself. Your generation is the first to arrive at college post-literate — raised on short-form video, dependent on algorithms, and increasingly incapable of sitting with a difficult text long enough to let it change your mind. Ninety percent of college students use AI academically. This makes you more reliant on the authority of others. Most professors will also stand between you and the text. They’ll tell you what Marx “really meant,” what Aristotle “failed to see,” as though an academic in 2026 has outsmarted minds that shaped civilizations. The good professors do the opposite: they put you in front of the book and they work with you to find what a great mind has to teach us directly. Find those professors, and read everything yourself. Say what you actually think. Seventy-three percent of conservative students report withholding their political views in class out of fear their grades will suffer. Our advice isn't political; it's intellectual. If you spend four years learning to say what's expected instead of what's true, you’ll graduate roughly where you started — just older, more credentialed, and more practiced at self-censorship. One study finds that nearly half of students show no measurable gains in “critical thinking” after two years in college. Keep this in mind as you make decisions about which professors to take and how to do your assignments. Taking a small hit on your paper to gain integrity and wisdom is usually worth it. Ask for real grades. Sixty percent of Harvard undergraduate grades are now A’s. Twenty-five years ago, it was 20%. It got so bad that the legendary Harvard professor, Harvey Mansfield, started giving students two grades: the official one for their transcript, and a private one reflecting what they actually earned. He called the official grades “ironic.” So here's a suggestion: Take your A, but also ask your professors for a “Mansfield grade” so that you know where you stand. And don’t avoid difficult courses to keep your transcript clean for law school. Get work experience before you graduate. Forty-two percent of recent college graduates are working jobs that don't require a degree. Many employers are projecting the next few years to be the worst college grad job market in years. A degree alone — even from an Ivy — is not a job guarantee. Seek out apprenticeships, internships, and real work starting freshman year. The students at UATX are connected with entrepreneurs and business leaders from day one. Many will graduate with four years of work experience alongside their degree. You can build something similar at your school, but you'll have to do it yourself. Understand how debt shapes your life. If you're paying full freight or even half, do the math with your eyes open. Your decision to take on debt will quietly reshape the trajectory of your adult life through countless small surrenders: the job you take because it’s safe instead of starting the company. The city you choose to live in. The relationship you delay and the kids you don’t have. For women, a $1,000 increase in student loan debt lowers the odds of marriage by 2% per month in the first four years after graduation. None of that shows up in the college brochure. If you're going to take on debt, treat it like the constraint it is from day one: save aggressively and make sure every dollar is buying something that will actually compound in your favor. Find the people who take school seriously. The best thing about a great school isn't the lectures or the library. It's the handful of professors and students who are genuinely there to learn — who read ahead, argue in good faith, and push you to be sharper. Find them. UATX is a small community of those who seek a serious education. At a larger university, you have to build this community yourself. * The most dangerous thing about an elite university is that it is very easy to do nothing for four years and still come out looking successful. The transcript will say you excelled. The diploma with the fancy crest will open certain doors. Your parents will be proud. And yet you will have coasted — through inflated grades, unread books, and borrowed opinions. Getting in is an accomplishment. Making the next four years worth it will be harder, and the right decisions will change everything. We wish you luck.

DELETE ONE FOREVER

Doesn’t take into account that there is value to redesigning homes and other spaces so humans have more and better living space Just like warehouses were redesigned to optimize speed/storage and access. Homes, offices and other spaces can be redesigned Just because a humanoid can do the job, it doesn’t mean it’s the optimal robot for the job and space utilization Why wouldn’t you use a smaller, less expensive, easier to maintain robot that has an environment it was designed for ?

A car in China can open its doors without touching, but it seems like people aren't ready for that yet 🚗