Eric Joyce

🚨New preprint from the lab🚨 🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK. biorxiv.org/content/10.110…

Patrick Walsh (@pjwalsh1688) in the @ericjoycelab defends his thesis tomorrow!

We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs. Please share with colleagues who may benefit! ericjoycelab.com/oligopaint-fis…

🧬 Want to do Oligopaint FISH but not sure where to start?

Dr. Randi Isenhart (@isenhartrandi) has a new 1st author publication for her work in the @ericjoycelab on: The length and strength of compartmental interactions are modulated by condensin II activity: dx.plos.org/10.1371/journa…

We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research. R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics. Read an In Memoriam published in Genes to Genomes: buff.ly/3EoNQh8

Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @CellCellPress doi.org/10.1016/j.cell…

Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.110…

ft. @HarkeJailynn, Jeewon Lee, @SonCNguyen, Staci Rakowiecki, @rebecca_yunker, @doug_epstein, @ericjoycelab (@PennGenetics), Arian Arab, @Melike_Lak (@PennEpiInst) & @SHugelier (@UPennPhysiology) @MolecularCell cell.com/molecular-cell…

Congratulations @HarshiniChandr8 💐 Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs BioRxiv: doi.org/10.1101/2024.0…

It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture. If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)

🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, @NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @Emblebi, @MoGen_Grads

@PeterLyLab @PennGenetics @PennEpiInst @UTSW_Pathology I had a fantastic visit to @UTSW_Pathology. Thanks @PeterLyLab for the invite.

Excited to host @ericjoycelab (@PennGenetics @PennEpiInst) for our seminar series. UTSW folks, please join us today at noon to hear about how our genomes are organized and regulated! @UTSW_Pathology

Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.110…

First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)

Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.110…

1/🧬Does chromatin organization shape immune responses? Our recent study with @NickAdams_PhD led by Reizis Lab and @leonidmirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇

📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. biorxiv.org/content/10.110… 👇Key findings:

We then show these changes are found within tissues and during aging. To learn more, check out our preprint! Thank you to all co-authors, the Buenrostro lab, and everyone at @HSCRB & @broadinstitute who made this work possible! biorxiv.org/content/10.110…