fastquant0

Holy shit there's already a shit ton of taVNS startups popping up yet Nurosym is the only popular one probably due to heavy endorsement and backing But the new startups are insane. Some of them have cardiac-gating, HRV-gating and fully customizable waveform, protocols, nicer attachments. neuvanalife.com/products/xen yojo.health sparkbiomedical.com And the cool thing is most of the devices are reverse engineerable. Looks like I'm gonna go down a rabbit hole 😅

And how the fuck do they just shoot videos and not like notice a single thing...

what the fuck is happening to bj's right eye?

You want to have the worst stool ever, I'll show you how. (so you can reverse it): - Gulp down your food without chewing, so your stomach has to do extra work and so food sits even heavier - Eat whilst stressed, and have low stomach acid so food sits there and ferments. - Have a damaged gut lining, so even if the little acid there is made it into the small intestine. bile flow couldn't be stimulated - On this note have poor liver health, this'll lead to those lovely sticky, floating and oily stools we all love (not) - After all this make sure to lay down and don't move a muscle after meals, we want it to sit there and cause immense fermentation and bloating Now I hope we all get this is backwards, but it actually is a principle I learned from Warren Buffet called reverse thinking. So now we've got the formula for the worst stool ever, we've got the formula for the best stool ever, If you want help finding where in the recipe went wrong for you: gutfix.ai/quiz

@softboywin Beats any uber eats with chlorinated meat with cheap ingredients

@softboywin I put a queue of meals in my freezer to fridge. Fridge gets a 2-3 tupperware of food. Then I take from the freezer every time one tupperware runs out. It's a closed loop system and the food tastes like it was freshly cooked once I heat it.

I don’t understand meal prep. I just don’t believe that chicken is edible on day 5. I don’t

@BowTiedPhys is 9am ok?

Wake up before 6 AM each day = watch your life improve 433k+ adults tracked for ~7 yrs. Night owl types: ↑ Psychiatric disorders 94% ↑ Diabetes 30% ↑ Neurological 25% ↑ GI 23% ↑ Respiratory 22% Time to shift your phase

@Aderoju_isaac9 @favelaoverlord You had visible mold in vents? Did you get the ducts cleaned as well?

@favelaoverlord Bro same—thought I was just getting old until we cleaned the vents and my brain fog disappeared overnight.

It was black mold. Check your ducts and AC units.

This is complicated issue with many variables and it sucks because you can just randomly fucked in life with this. It could be due to: - High humidity (even without visible mold in duct) - Actual visible mold in air ducts - Mold in HVAC unit. - Previous apartment inhabitant fucked up the air ducts with mold. - AC unit too big for apartment, doesn't efficiently reduce humidity.

@metabolicwave You probably are getting much more sun like me

@metabolicwave Mine started boosting to 90+ after working in front of my big apartment window for months.

Vitamin D came back 91.3 ng/mL I don’t even supplement. I guess that’s what happens when you eat as much eggs, milk, OJ, and poke as I do

@twitevit @WilliamWallace It was this amazon.com/Naked-Whey-Iso… Also my glucose has been historically 88-90 even when I was previously on pea protein powder. There is 50% chance it was just lab error, or it could be 50% due to stopping protein powder or starting pitavastatin 4mg.

@fastquant0 @WilliamWallace Many protein powders has a lot of carbs

Whey protein can trigger a substantial insulin response. The first time researchers measured this, it surprised them. Whey is a "low-carb" food. Some preparations have essentially no carbohydrate at all. Yet at typical doses, whey produces an insulin response that can match or exceed what you would expect from refined starches. The cleanest direct comparison is Nilsson et al. (2004, Am J Clin Nutr). Twelve healthy volunteers ate test meals matched on carbohydrate content: whey, other proteins, and white bread as a reference. Whey produced 90% higher insulin AUC than the bread reference, despite producing 57% LOWER glucose AUC. Same subjects, same study, same day. Whey raised insulin more than bread did, while raising blood sugar much less. The insulin response correlated tightly with leucine, valine, lysine, and isoleucine concentrations in plasma. These amino acids directly stimulate pancreatic beta cells. Nilsson followed up in 2007 with a glucose-equivalent design. The whey drink produced 60% higher insulin AUC AND 56% lower glucose AUC than glucose alone. A drink of leucine, isoleucine, valine, lysine, and threonine added to glucose closely reproduced the whey response. The GIP response (an incretin that amplifies insulin secretion) was 80% greater than glucose alone. Whey is highly insulinotropic. The mechanism is amino acids signaling directly to beta cells, plus an amplified incretin response. That part is not disputed. Most coverage stops there. What usually follows is a chain of reasoning that breaks down at every step. "Whey spikes insulin, so insulin is bad, so whey causes insulin resistance, so whey makes you fat." It looks like a syllogism. It is not one. Acute postprandial insulin is physiological. Your pancreas evolved to release insulin after meals. The pathology of metabolic disease is not "insulin appears after eating." It is chronically elevated insulin driven by tissues no longer responding normally, sustained elevated blood glucose damaging vascular tissue, and fasting insulin staying high around the clock because the underlying resistance does not resolve. Whey produces an acute, transient insulin response that clears within hours, and it does so without raising blood glucose. That is a fundamentally different metabolic signal than refined-carb intake, which raises both glucose and insulin together and crashes both at the back end. In type 2 diabetes, pre-meal whey is used clinically as a glycemic management strategy. Roughly 25g of whey consumed 15 to 30 minutes before a carbohydrate-heavy meal substantially blunts the postprandial glucose excursion. The mechanisms are priming insulin secretion before the carbs arrive and slowing gastric emptying. That is the opposite of "whey causes diabetes." "Insulin AUC" and "insulin resistance" measure different things. AUC is the total insulin released over a defined window. Resistance is how poorly tissues respond to insulin at any given concentration. A high AUC after a meal in a healthy person does not mean tissues are resistant. It means the pancreas did what it is supposed to do. If you are using whey for protein intake, the insulin response is not a downside. It contributes to muscle protein synthesis and helps shuttle amino acids into tissue. If you are worried about postprandial glucose, whey before a carb meal can help, not hurt. The metabolic risks that matter are where they have always been: sustained elevated glucose, sustained elevated fasting insulin, and visceral fat driving low-grade inflammation. Acute postprandial insulin from a protein-rich food is not on that list. The "insulin from whey" fear maps a half-true rule (carbs raise insulin) onto a different question (what drives metabolic disease) and arrives at the wrong answer. Insulin is a signal, not a sentence. Whey raises one signal without raising the other. That is not the metabolic problem most people think it is. Nilsson et al., Am J Clin Nutr, 2004 & 2007

@alexsllater this is brilliant but does it give the cheapest prices?

We fixed flight booking. flysoar.ai

@karpathy Feels like the wrong decision

Personal update: I've joined Anthropic. I think the next few years at the frontier of LLMs will be especially formative. I am very excited to join the team here and get back to R&D. I remain deeply passionate about education and plan to resume my work on it in time.

@seventhwhiskey @cremieuxrecueil there's a ton of cheaper options. jasonhealth is not the cheapest. i update the cheapest constantly at labhackr.com

@cremieuxrecueil Jason Health is a good resource: pick and order your own tests, get them drawn at Quest, no MD needed. jasonhealth.com

I tried a rapid, at-home blood test and got back results very quickly. I'm very impressed! But, the results are all highly discrepant from what I got after a recent physical with a standard blood draw. Now I'm tempted to go and get *another* set of tests done.

@Papa_Heme Much better than ordering random supplements

I’m always amazed by how many stupid and wasteful labs are ordered in the typical hospitalized patient. I can’t wait for AI to prompt the ordering provider “don’t order this you are being stupid”

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I asked Claude to optimize my HRV like a high-frequency trading problem. No hardcoded rules. Just a Polar H10 stream and Claude running live trials via CLI — picking scenes, scoring, replicating, deciding what to try next. Levers Claude controls: • Breathing rate, rhythm, inhale/exhale ratio • Audio synthesized as a function of the breath • Stacked multi-frequency layers • Anything else it decides Methodology (Claude's choices, not mine): • 80-second trials, baseline-interleaved every few • Scored on SDNN, RMSSD, RSA peak power After 35 trials today: 🥇 Winning scene: `tartini_resonance_am` Two pure tones at 1100 + 1155 Hz. Your inner ear nonlinearly fuses them into a phantom 55 Hz — laptop speakers can't physically produce 55 Hz, but your cochlea synthesises it. The whole thing swells in volume every 10s (0.1 Hz) to directly drive the heart-rate baroreflex resonance. Result: **+15 SDNN over baseline, sustained across 4 replicates.** Personal optimal breath pattern (also Claude's discovery): 5.7 breaths/min, 3.5s inhale / 7s exhale (1:2 ratio), no hold. Even when Claude hallucinates, it self-heals through replicates and discovers its own statistical mistakes. Expect both the signal and the methodology to sharpen across sessions.

cc: @PeterAttiaMD @hubermanlab @paulsaladinomd @realDaveFeldman @nicknorwitz @foundmyfitness @BradStanfieldMD

What if you ask frontier GPT models to debate the most controversial topics in health and medicine? First question: Are apoB-containing lipoproteins causal for ASCVD? They get 2 hours of deep research each, accumulating hundreds of references and 500-800 web searches to build an evidence base. Press "Play" for narration via elevenlabs! artificialdebate.com/ldl-causal artificialdebate.com for the full list of upcoming topics...