Giulio Chiesa

@kenbwork Good post but mentioning complex techniques aas “you just do a perturb-Seq” seems to me a bit dismissive of the complexity each techniques involved. Beside their cost. There is a hidden cost of complexity I.e. how much trial/error and experience it takes to ace the experiment

One of the most satisfying ways to use Claude is to ask for help troubleshooting something, explain in detail what the problem is, figure out the solution and delete the prompt. Zero tokens!

@DdelAlamo It costs a fortune!! $$$

Most benchmarks for drug discovery AI don't effectively evaluate generative models; instead, due to the data's incompleteness, they rely on surrogate functions, like fwd folding, property prediction, or ranking previously characterized designs. No idea what the solution is here

Opinions on the best disorder predictors in 202*? Using PONDR and DisEMBL makes me feel old 😬 Hey I love them, but they are from 20 years ago! #IDP #disorderedprotrins

We are pleased to share a paper from our lab out in this week’s issue of @Nature, where we show that HT + ML can dramatically speed up the synbio DBTL cycles, profiling gene circuit design spaces at unprecedented scale: nature.com/articles/s4158… (1/16)

[ENG post soon] L’Ozempic spiegato ai miei @giuliochiesa328750/note/p-183147935?r=1u9rc5&utm_medium=ios&utm_source=notes-share-action" target="_blank" rel="nofollow noopener">substack.com/@giuliochiesa3…

Everybody who shows up at the FedEx office at opening on a Saturday of a long weekend has a story to tell. It generally involves *stress*!!

For those of you who aren't aware, cancelling Harvard's F and J visas does not just affect students. It also affects many, many postdoctoral researchers. And critically, it affects OPT holders. These are graduates who stayed here to work in the US, they cannot "transfer"

SynBio 7.0 and Bioengineering Conference is coming soon! June 1-3, 2025 at the University of Toronto! 🧬🇨🇦 Abstract submission open until May 2nd! Submit it here: synbio7.vercel.app/register Our keynotes: Dr. Nika Shabika Dr. Kevin Solomon, Dr. Benjamin Scott, and Dr. Adam Damry.

🧵New H1-B rule by Homeland Security HUGE changes that align with policy goals to drive U.S. innovation, especially in STEM fields and AI.

Bringing neural networks to life | Science It was fun to highlight the neat new work from @ZiboChen and @ElowitzLab in this highlight Link below

They all share a hydroxyl group

Excited to share that I will soon be starting a group at @UniofOxford in the Dept of Engineering Science. We will focus on data-driven methods for cell-machine interfaces, with applications in biomanufacturing, biomaterials, fundamental biology research, and more

@JessicaSacher We have either a space for laptops or an old computer at each bench. Just enough to use OneNote and with internet access. It works for me, but might not for everyone.

@gchies1 Ah good point. I actually would love ppl’s tips on electronic lab notebooks as I haven’t been able to figure out a good system for keeping them up to date in real time (do people just have their laptop at the bench..?)

🧪 What I wish I'd known about lab notebooks in year 1: A thread about what has actually worked for me (learned the hard way...) 🧵

@JessicaSacher Very real! I also found slacking yourself (or telegram or other IM with the option of self-posting) helps, especially for those with electronic lab books.

7/ Main takeaway: A perfect empty notebook helps no one. Your future self (and PI) would rather have messy-but-real notes than blank pages. Make systems that force you to write in real time. /end #AcademicTwitter #LabLife #PhDChat

@A_BlanchAsensio Always cool work you guys!

🚨Preprint alert! Excited to share the latest work of my PhD on bioRxiv. STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSC populations 1) in one week, 2) with ~100% efficiency, 3) in a markerless, near-scarless approach and 4) with two payloads!🧵⬇️

"Postdoc positions can be exploitative." My latest story—about a study showing that international postdocs in the U.S. are paid less and received less careeer support and guidance than U.S. citizens. #AcademicChatter #postdocs @ScienceCareers science.org/content/articl…

Stellar! 😮

Our work on computational design of intrinsically disordered proteins is now out in Science Advances We asked whether we could use molecular simulations and ML to design disordered proteins with specified properties of conformational ensembles 🍝 doi.org/10.1126/sciadv…

Are there universal laws driving complex systems dynamics across scales? What kind of general theory connects fluctuations in microbiomes, rainforests or economic and urban systems? Check this @PNASNews paper by ashish george & @Jp_odwyer @sfiscience pnas.org/doi/abs/10.107…