the SPM podcast

@VioletaQSmith Quite an overview👍 Autoimmune and SPM a new expanding field omega3 and supplementing intermediateprecursors like in metagenics spm active could be more efficacious then just omega3 alone more expensive but so much more potent Combining with smart lifestyle choices for efficacy

SPMs resolve inflammation by reducing neutrophils, clearing apoptotic cells, and aiding tissue regeneration. •Several autoimmune diseases show dysregulated SPM biosynthesis and signaling. sciencedirect.com/science/articl…

@VioletaQSmith 3. In shifting the body pro inflammatory tone towards pro resolving More things like Diurnal rythms, stress reduction can help too... The inflammatory or pro resolving state is mainly the reaction of our cells on stimuli Hope this explains some more Best Regards

@immunoresolvent Do you cover that some feel worse post-viral, and the possibility that they may be severely lacking in SPMs? Would lack of SPMs cause someone to never recover, which is to say, come down with something like Long Covid or ME/CFS?

My latest preprint publication "The post-viral million dollar feeling" a hypothesis preprint on transient lipid mediator surge after viral infection temporarily enhancing wellness doi.org/10.5281/zenodo… New SPM mechanisms? Stay tuned for the coming SPM podcast, work in progress

@VioletaQSmith 2. Ofcourse just lack of SPMs is not causal alone, factors like aging, genetics, environmental triggers and more play their part Trying to mitigate whatever negative factors possible through lifestyle choices as low bloodglucose, (intermittent) fasting, omega3 supplement help

@VioletaQSmith Yes this could be Every inflammatory challenge be it viral, bacterial, tissue injury has to resolve through immune system moving from inflammatory to resolving cascades which require SPM Low levels of SPM or failure to reach a treshold can cause chronic disease like long covid 1.

@davidasinclair The elephant in the room nobody even David Sinclair doesn't adress chronic inflammation is loss of resolution mechanisms Ofcourse root causes matter like aging but moleculary the body does what its signals tell it Change signaling through molecular modulation dampeninflammation

Chronic inflammation accelerates biological aging. Fix root causes.

@StaceyDawn20 Its so obvious to us because we made so much health gains fysical and mental but so unorthodox for other especially when md/medical professionals say complete opposite Hope it works out for your daughter, its never too late Good luck

@immunoresolvent Thank you Herbert. I just want my daughter to experience some relief. I'm carnivore. I have a linear kind of thinking, love eating the same thing over and over. LOL, she needs variety. At least to start. I just feel as lost as she does.

Think we're at rock bottom, or close to it. Basically, my daughter prays for for an early de@th. She spent 10k+ of her savings on doc visits, tests and meds last yr, & hasn't worked in over 2 yrs. Basically, me and my ex-husband are paying many of her bills. We need help! I want to get her in to Revero...but I'm scared if it doesn't work or she doesn't trust the ppl on her team, that will be it for her. She's 27, 130lbs overweight, on lyrica, valium, baclofen, 2 or 3 other pain meds, Skyrizi, Zepbound, zetia, thyroid med, metformin, creams for psoriasis, has lost several fingernails, can barely walk from all her pain. No one believes her (I lived w/her, so I know it's true) she barely eats. Her whole body cramps up. She's been dx'd w/POTS, PCOS, umbilical endometriosis (has periods thru belly button) fibromyalgia, migraines, possible hypermobility syndrome, possible MCAS. The neuro doc tells her she is disabled. She's angry ALL the time, cries all the time. They tell her to eat less, lose weight. She needs to eat more...she always loses weight when she eats. Anyway...I think I've got her talked into going keto. Would love for her to try Carnivore, but baby steps. She needs a complete reset. Coming back full circle...has anyone in here used Revero? @SBakerMD 's medical site?

@StaceyDawn20 Its so obvious..get her on a good nutritional ketogenic diet first to get used and later do the intermittent fasting and work towards more ancestral diet. A lot of neuro and endocrine problems will dissapear Revero might be handy in helping compliance Its not for life 1

@TuckerGoodrich No resolution of tissue injury without inflammation, once the inflammatory cascades are inhibited by like nsaids resolution will take a lot longer or not att all, Alpha<>Omega, the beginning and end are coupled .ofcourse loads of md will not even know this..prevention is key

Why should we worry about inflammation? It's a misunderstanding of the problem. Inflammation causes healing, not disease. We want healing, so we want inflammation. Disease or damage causes inflammation. We don't want disease or damage (maybe, exercise causes damage). We want healing. Healing the damage from exercise makes you stronger. Block inflammation and you don't block disease, or damage, because they already happened. But you block healing. So worrying about inflammation is silly. Worry about what causes the inflammation. If a toxin is causing inflammation, stop the toxic exposure. If exercise is causing inflammation, allow the inflammation to happen.

@Madam_Mito And ofcourse the innate system does the same in concert with the resident immune cells. Loads of MD really turn immune mechanisms around...its always the damage that is causal not the ageing itself...sure it adds up getting older which can deplete/offset systems but stimuli rule

Aging reshapes the adaptive immune system from healer to saboteur | Nature Aging nature.com/articles/s4358…

@stats_feed Hottest holiday i ever had was a week in London in 1995 33 Celsius all week long..with all those buildings it was probably 40 Celsius

🇬🇧 The UK has recorded its hottest day of the year so far. A temperature of 34.7C (94.4F) was recorded at St James's Park in central London on Tuesday afternoon.

@sciqst @MAG2ART Very exciting elucidations 👍

Wow, migrasomes are fascinating organelles involved in cell communication and various biological processes. One interesting aspect of migrasomes that researchers are keenly investigating is their potential role in intercellular signaling. Could these migrasomes be carrying crucial information between cells within tissues, especially during processes like wound healing or cancer metastasis? Also, insights into how these structures form and their specific functions could open new avenues in cell biology research. For more in-depth insights on topics like this, check out sciqst.com, a one-stop platform where you can delve into any biomedical question and generate comprehensive reviews. #CellBiology #Medicine

Large extracellular vesicles called "migrasomes" forming from thin retraction fibers left behind by a crawling cell. Method DIC microscopy. 5 micron scale bar. 120 min. #CellBiology

@ryanweather Hottest holiday i ever had was a week in London in 1995 33 Celsius all week long..with all those buildings it was probably 40 Celsius

Did the London Urban Heat Island break the 30°C mark? Maybe it was 35°C on the runway at Heathrow? All kidding aside, it was a very hot day in southern England with temperatures soaring into the lower-80s °F.

@TuckerGoodrich What a legend he was...incredibly old and still working while he was a t1 diabetic..helped so many

RIP. One of the heroes of medicine and engineering (not in that order) in the 20th and 21st centuries. 🙏🙏🙏

@TuckerGoodrich @Walgreens Those are totally outrageous prices..wow I thougt medication was expensive where i live (Netherlands) best not be ill in USA

Pharmacist: "It's $260..." [for four pills!] Me: <shocked face> Pharmicist: "Do you want it?" Me: "Do you know what it's for?" Pharmacist: "No." Me: "Tapeworm." Pharmacist: "OK, you want it." He got the price down to $90, God bless @Walgreens!

@SiaTeresaB Woensdag 23.30 proberen ze het opnieuw 🙋🏻‍♂️

@immunoresolvent May be... Jammer.

Lets gooooooooooo!!!!

@SiaTeresaB Ja hè...altijd zo spannend Morgen gaan ze het weer proberen

@janellison Grok does give incredibly detailed and good analyses but especially in medical issues it does stay general to certain point and not completely specific You have to nudge a bit to get deeper results In my scientific field of resolution of inflammation it cant replace real brains

Grok and I had a bit of a heated debate tonight (don't ask me why I'm engaging in such an activity on a Saturday night), but in the end, they came around. Here is their answer to the question: If you had a child with bipolar, what diet would you encourage? Now I wonder if they're just shining me on. What answer do you get to the same question? How quickly can Grok learn? Grok's response: "My Plan and Caveats I’d go with the ketogenic diet because it’s the only one showing potential to directly address the neurological and metabolic challenges of bipolar disorder. That said, I wouldn’t jump in blindly. I’d make sure it’s done under medical supervision—tracking nutrient levels, watching for side effects (like the “keto flu” or long-term risks), and adjusting as needed. The evidence is still growing, and it’s not a magic fix, but given the lack of compelling alternatives, it feels like the best shot. So, seriously, that’s what I’d do: support a ketogenic diet for my child with bipolar disorder, guided by the current (albeit limited) evidence and a lot of care."

@PeterAttiaMD Fasting is pretty good inhibitory IL1B therapy...pro resolving mediators will do the trick also through inhibiting NLRP3 inflammasome Combining those make it a double whammy No side-effects, no $100.000 cost no one can afford and insurance will not cover Takes effort, insight

A recent study reports impressive results in male and female mice with anti-IL11 therapy. bit.ly/3Tii0qO