IMRΛN

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

Fantastic read. We’re shifting from code generation to code verification as the bottleneck and competitive moat.

We just released Claude Code channels, which allows you to control your Claude Code session through select MCPs, starting with Telegram and Discord. Use this to message Claude Code directly from your phone.

Israel has been pummeled all night. Based on my counts of alerts and reports of landings from open sources the number increased tonight, though there are no reports of casualties. My Whatsapp groups are filled with people having breakdowns after not sleeping for two weeks. In Jerusalem 4 alerts were heard in a 90 minute span. Iran has been able to increase the number of launches daily. Everyone seems angry at the IDF and Netanyahu for lying about the destruction of Iranian capabilities.

"Massive investment in AI contributed basically zero to US economic growth last year," per Goldman Sachs

Yes. I stopped using it too. It has a pretty noticeable effect on your immune system, making it less effective. A few weeks after Rapamycin, I started to notice signs that was athletes foot starting to form on the skin of my feet! Stopped Rapamycin and after a couple more weeks the athletes foot began to recede and appears to now be gone. Antidotal but I’m convinced it was the rap.

Introducing the Secure Exec SDK Secure Node.js execution without a sandbox ⚡ 17.9 ms coldstart, 3.4 MB mem, 56x cheaper 📦 Just a library – supports Node.js, Bun, & browsers 🔐 Powered by the same tech as Cloudflare Workers $ 𝚗𝚙𝚖 𝚒𝚗𝚜𝚝𝚊𝚕𝚕 𝚜𝚎𝚌𝚞𝚛𝚎-𝚎𝚡𝚎𝚌

Statement from President Trump on South Pars Gas Field:

⚡️The professional middle is entering a slow liquidation. That is what is coming. A lot of six figure workers still think they own scarce cognition. They do not. What they actually own is a seat inside an organizational diagram that is about to be rewritten. For twenty years, companies paid armies of people to summarize, coordinate, package, analyze, report, reassure, sell, recruit, and administratively maintain complexity. AI is about to reveal how much of that layer was never true scarcity. It was overhead wearing prestige. That is why this gets dangerous. The people in that layer built expensive lives around the illusion that their salaries were durable. Big mortgages. daycare. two income households. private schools. lifestyle debt. identity fused to title. So when the compression starts, it does not feel like a normal labor shock. It feels like your class position is being revoked. A person loses the job and suddenly realizes the house was never a fortress. It was a fixed-cost trap financed by continuity. The next 12 to 18 months are likely to be ugly because companies have finally been handed a believable excuse to thin the white collar herd. They can say AI. They can say efficiency. They can say macro caution. They can say market conditions. The language does not matter. The result does. Fewer seats. Longer hiring cycles. More ghosting. Lower offers. Higher bars. More people with impressive resumes chasing jobs beneath prior status. The market will keep telling itself this is temporary. A lot of it is structural. And the cruelest part is that this probably will not arrive as one cinematic crash. It will arrive as social downgrading. The title gets softer. The comp gets cut. The search takes longer. The savings get chewed through. The role accepted is smaller than the last one. The family says it is fine. The person knows something has broken. That kind of decline is much more psychologically destructive than one violent break because it makes people live inside the decay of their own ranking. Housing is where this becomes visible. The professional class was supposed to be the stable bid under the market. If enough of them lose income security while carrying large mortgages, the house stops being optionality and becomes a restraint device. People stop moving. Listings freeze. Spending contracts. Families become geographically trapped because leaving means crystallizing loss or taking a much worse payment elsewhere. The labor shock and the housing shock start feeding each other. Society is about to discover how much of the tax base, consumption base, and institutional calm sat on a white collar class whose value was inflated by a pre-AI information economy. That class thought it had made it because it was paid well. A lot of them were just being temporarily overcompensated to keep the administrative machine running. When the machine needs fewer humans, the paycheck premium gets repriced hard. Bottom line: A lot of six figure jobs are going away. A lot of the people in them will not get equivalent replacements. The pain will concentrate in the salaried professional class with high fixed costs and no ownership cushion. The official data will lag the lived reality. The social mood will get darker long before the statistics fully admit why. The real truth is simple: The next phase is the collapse of professional security. The middle is about to learn that income is not the same thing as safety.

Fantastic read. We’re shifting from code generation to code verification as the bottleneck and competitive moat.