@phonybone I didnt know wtf was happening when I watched EoE for the first time
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Antiagng
348 posts
Evangelion is a great 8-9/10 anime. End of Evangelion is one of the greatest movies of all time
pharaoh@hithisispharaoh
When I finished Evangelion I didn't think it was quite a high favorite of mine but after EoE rocked my world its really got me reconsidering. I haven't been able to think about anything else for 3 days.
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@biogerontology Well, and how do you plan to deal with somatic mutations in the brain?
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Aging and diseases of aging = our main common enemy. We need to fight it together around the world. People should not be fighting other people. People and AI should be fighting aging
Yicai 第一财经@yicaichina
Our longer-term vision is to use AI to tackle human aging problem. We hope that one day, we can leverage AI to develop drugs that delay aging in healthy individuals, enabling everyone to live healthier and longer lives, Ren Feng, chief scientific officer and Co-CEO of Insilico Medicine, told Yicai at the #WAIC2026. @InSilicoMeds
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@hsu_steve This is determined based on human brain and Heart cells, Right? Probably the shittiest thought that i have is targeting mutations with the immune system, improving dna mechanisms like that whale and reprogramming the brain with whatever youthbio does, replace the heart
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"if nearly all other reversible aging processes were eliminated, the accumulation of DNA mutations alone could limit the median human lifespan to around 146-194 years, roughly twice today's human longevity."
Have not looked carefully at their model, but clearly accumulation of mutations via cell division places a limit on longevity.
SciTech Era@SciTechera
Scientists just estimated the upper limit of human lifespan determined by somatic mutations 👀 Researchers from Skoltech and AIRI developed a mathematical model to estimate how somatic DNA mutations influence the upper limit of human lifespan. Their model suggests that if nearly all other reversible aging processes were eliminated, the accumulation of DNA mutations alone could limit the median human lifespan to around 146-194 years, roughly twice today's human longevity. The model also found that somatic mutations reduced the median lifespan from a theoretical non-aging baseline of 1,759 years to around 156 years, highlighting how powerful mutation accumulation can be even in an idealized scenario. This study also identified brain neurons and heart muscle cells (cardiomyocytes) as the biggest longevity bottlenecks because they regenerate very slowly and accumulate mutations over time, while regenerative organs like the liver can replace damaged cells and maintain function much longer. Researchers conclude that somatic mutations are a major driver of aging, but they cannot fully explain human aging on their own, suggesting other hallmarks of aging contribute comparably to lifespan limits. These findings provide new insight into one of the fundamental hallmarks of aging and could help researchers develop future therapies aimed at extending healthy human lifespan.
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You’ve heard CRISPR can cure disease. The wall it keeps hitting is delivery. To reach a gene inside your body, you need to get the molecular scissors into the right cells, carried by a harmless virus with a tiny hold. The usual scissors, Cas9, barely fit, which is why the first CRISPR cure costs about 2.2 million dollars and is done outside the body.
@DoudnaJennifer’s lab tackled that size problem with an AI trained only on protein shapes, never on a letter of DNA. It redesigned about a quarter of TnpB, a natural mini-editor a third the size of Cas9. The new version cut human DNA around 50 percent of the time, versus 28 percent for the natural one.
Size is the point. A smaller editor fits the virus and reaches organs Cas9 can’t. The strange part is that a program that never saw DNA rebuilt the exact chemistry that grabs it.
Cells in a dish so far, no animals, and it reworked a natural enzyme, not one built from scratch.
Eric Topol@EricTopol
—How do you take genome editing to the next level? —AI science.org/doi/10.1126/sc… @ScienceMagazine @DoudnaJennifer @DoudnaLab @igisci
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@3310olivia Not watching your family, pets and yourself deteriorating would be so good.
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@KarynATetrault Yeah, why? What’s the actual purpose of aging? We would still die. But why doe we age?
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Why are people so casual about the fact our bodies begin to decay at 30?
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i dont understand why we are saying longevity drugs will specifically help people below a certain age like 70. i mean, if they do work out using Sinclair-esque approaches, i am pretty sure there is no reason why there'd be that kind of a cap. if we do a bunch of stem cell-esque work, it will actually create a whole new industry, kind of like CAR-T did but a lot lot bigger. ex vivo regenerative medicine would be awesome. honestly, Japan is doing some of the best work in that space; if you are building in this, VISIT JAPAN ASAP
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@NORMALNAME_11 @TachyonLov3r I hate the medal progression and the final battle, also the meme means that they hate the game bc it doesnt run well on their pcs
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@TachyonLov3r People who hate Unleashed usually don't hate the Day Stages though 🤦
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@realNathanCheng I feel lost, thinking that there will be a time where I already lived enough with my decrepit self that I will forget my true self
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it's not enough to just smile and "agree to disagree" with people who are pro-aging / pro-death.
if you really believe aging kills 110,000 a day and you believe death is bad, then you have to be unflinchingly intolerant of those people.
Derya Unutmaz, MD@DeryaTR_
I am going to say something really blunt, intentionally: Aging is my number one enemy. I consider it the most horrible affliction of humanity that has killed billions of people, including my dear father. As such, it’s hard for me to respect anyone who glorifies my worst enemy.
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@realNathanCheng @grok I’m more concerned about how long it will take us to keep our bodies from decaying
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so great that we can appeal to @grok rather than arguing with "people who are wrong on the internet".
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Benefits of curing aging that nobody talks about:
Recognising yourself in the mirror again
Youthful glow
Feeling alive
Having the energy to travel, hike and party all night
A body that feels like yours
Motivation
Parents staying healthy
Never experiencing ageism
Beauty
Youth
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human beings are born with this same ability btw. your thoughts are so powerful, they can not only reshape your entire reality but also send information to reprogram your cells, rewrite your DNA, control your immune responses, and reorganize your whole body on a cellular level
Night Sky Today@NightSkyToday
JUST IN🚨: The octopus can edit its own DNA while it is alive. An evolutionary anomaly that breaks the rules of biology.
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@Midfaceincel Brother just use a wig and use finasteride or save for an hair transplant
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I know this is a joke, but serial killers probably operated under the radar with impunity for centuries. The “era” of serial murder in the 60s-80s was a “sweet spot” where surveillance and forensics had advanced to the point they could be detected, but not yet easily caught
(doctor) Alex Grease@dodgonkulator
The reason we don't have serial killers now is nobody gives a fuck anymore
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@vladusatii @AlexanderKalian Im sure he knows more than me, but why is supposed to get exponentially worse? Isnt the point of things like SENS to clean damage and then repair? Why would an healthy body get exponentially worse to maintain, or he is just talking about LEV on normal aging?
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If progress adds >1 year of healthy life /yr, expected lifespan begins diverging. That isn't necessarily science fiction, that has literally.. happened. Historically. It may not be consistent, but it has happened.
Using log-scales to predict AI-biotech is risky bc it assumes future innovation resembles past innovation.
"Keeping organisms alive..exponential" isn't necessarily true either. Entirely new intervention paradigms do appear, like cell replacement, partial epigentic reprogramming, nanomed, etc. You are quite cynical.
If AI compounds across augmentation of experiments, automation, and hypothesis, rate of biomedical discovery will increase drastically.
You omit really important information, like the fact that ER-100 HAS ENTERED HUMAN TRIALS.
Some therapies are maintenance systems-- like anti-uPAR CAR T to target senescent cells was effective in mice. You don't think that in ~<50 years or so, at least one therapy will show real age reversal in humans?
Humans will begin to get antsy -- they will attempt to solve aging. Not enough innovation in the field yet bc of senior gatekeepers.
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AI will...
- Perform robotic surgeries
- Control elderly care robots
- Scan DNA for disease risks
- Analyse medical scans quickly
- Discover drugs with improved success rates
AI won't...
- Make you live forever
- Upload your mind into a computer
- Make your cat levitate
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@Robotbeat If its possible I think it can be done if theres a race to it
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We're going to have to basically invent biological immortality tbh. And we aren't close. I have no solid hints that this problem has been solved yet. (It is fundamentally possible to solve aging, though, and if you think otherwise, you're objectively wrong...)
Robotbeat🗽 ➐@Robotbeat
If the whole world develops East Asia's TFR, practically the end of industrial civilization. It takes ~40-50 yrs for effects of low TFR to hit, & during that time, you're reaping economic benefits of a low dependency ratio. Then, 80-90% of Earth's fertile population disappears.
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