
Isaac Howe
23 posts

Isaac Howe
@isaachoweVC
Rutgers sophomore who spends all day thinking about VC and startups. My Substack: https://t.co/3dRJOHQb6Q








TBPN has been acquired by OpenAI! The show is staying the same and we’ll continue to go live at 11am pacific every weekday. This is a full circle moment for me as I’ve worked with @sama for well over a decade. He funded my first company in 2013. Then helped us fix a serious logjam during a critical funding round a few years later. When I took my second company through YC, he was president at the time, and then when I joined Founders Fund, the first deal I saw in motion was the post-ChatGPT round in late 2022. And as we started growing TBPN last year, he was the very first lab lead to join the show. Thank you to everyone that has been a part of TBPN until now. The last year has been the most fun and rewarding part of my career and we’re excited to have more resources than ever going forward.

This is for everyone who has a dream that simply seems out of reach. 11 years ago I started 20VC as an 18 year old in a bedroom in London. I didn’t know a single VC and had no money. I wrote down the names of three legends of the venture world. I have had two on the show previously and today I complete the list that 18 year old boy made. This was 11 years, 3,000 shows, 3,750 hours, in the making. Never give up, never doubt yourself, stay focused, row your own race. It will come through. Welcoming Marc Andreesen to 20VC today. (Links in comments)


A CEO from one of our portfolio companies shared this with their team. I’m re-sharing it with their permission, because it resonated and reflects what all founders and CEOs should be communicating. -- We are living through a period of compounding change. And in moments like this, the biggest risk is no longer making the wrong decision. It is moving too slowly while the world moves around you. There are two paths. We can play defense: - Protect what we have - Optimize what works - Wait for clarity It feels safe. It isn’t. Or we can play offense: - Learn faster than the environment changes - Use new tools to solve old problems in better ways - And create entirely new strategies and businesses That’s where the opportunity is. Challenge yourself to do things faster and better than you have ever attempted. Stay uncomfortable. Stay on the front foot.
















