Josh Dong

If you ain't cheating you ain't trying. GLP1s are the real Cluely

@Gaurab @grok please verify these claims

Eli Lilly makes tirzepatide with a DEA List I controlled chemical, a Group 2A carcinogen, and a PFAS forever chemical. Novo Nordisk uses yeast. Novo's Ozempic backbone is fermented at their patent-protected plant in Kalundborg, Denmark. Tirzepatide and the synthetic GLP-1s are made via solid-phase peptide synthesis of fragments, then coupled in solution. Each cycle of deprotection uses piperidine, controlled by the DEA under Code 2704. It is the core of fentanyl. Each tirzepatide takes roughly 38 piperidine cycles across its fragments. Every SPPS step uses dimethylformamide as the solvent. DMF's residual limit was set at 880 ppm in 1997. The IARC reclassified it as a probable carcinogen in 2018, but the limit hasn't changed. Cleavage uses trifluoroacetic acid, a forever chemical. There is no harmonized regulatory limit for it. Toxicology data is too limited to set a safe daily dose. Approved drugs pass the specs. Every synthetic GLP-1 is made with these chemicals. One kilogram of API generates roughly twelve thousand liters of solvent waste. Novo built the modern route. Everyone else is stuck in 1997. Tens of millions take GLP-1 every week. We engineer enzymes to manufacture chemicals. Developing a yeast in the lab is not the same as running it in production. Novo has fermented GLP-1 peptides at industrial scale since 2010.

@cremieuxrecueil so don’t die

Practically, the only rigorously proven things you can do for life extension right now are: - Don't be fat - Be fit - Control your blood sugar - Control your blood pressure - Have low cholesterol - Don't poison yourself Almost everything else is speculative and dubious.

dentist told me i grind in my sleep and i respect the hell outta that

🤖 Josh Dong: 58/100 clone fidelity — Very Close "I have gone from 'let’s just ship it' to 'absolutely not until the security review is real' without noticing I became that person." are you just a system prompt? → replacebyclawd.com/?url=https://w…

Insane studies showed that polyester underwear destroys sperm and makes men infertile, and wrecks hormones while preventing pregnancy in women. (🧵1/7)

So much software exists simply because macos users dont have a good window manager

Baby Screen Time Linked to Brain Prematuration The screens that increasingly fill babies’ early days can shape how their brains handle uncertainty and stress later on, according to recent research. The study found that the average baby spends more than two hours a day on screens from birth to age two, and that this early exposure leaves traces in the brain that persist for more than a decade, influencing how quickly they make decisions and how prone they are to anxiety as they grow up. The findings, published in eBioMedicine, come from one of the longest‑running studies to follow the same children from birth into their teens. The study links early screen exposure to brain changes that are, in turn, connected to slower decision‑making and mental‑health problems that show up years later. Early experiences help shape how flexible and resilient the brain later becomes, Pei Huang, the study’s first author, said in a statement. When certain brain systems specialize too quickly, he said, children may be “less able to adapt later in life.” 👇 theepochtimes.com/health/baby-sc…

$420 to whoever figures out how to do this first

@nikillinit Hey this is pretty fire actually haha

SOC tuah

@Nature @HugoAerts @simonbernatz Think about that @NatureNV nature.com/articles/d4158…

@straceX @josiezayner This is the efficient market realized

the internet is no longer a place to explore. it is literally just five giant apps consisting entirely of screenshots of text from the other four apps.

Actual builders are few. Much of business is a wrapper. Mercury? Fidelity? Great products, not actual banks. Don't even have to get started with AI companies. Distribution, UX, and good business have long been far more important than product.

Anyone go to Ruthia He's sentencing today? curious the results. justice.gov/opa/pr/founder…

If you're preparing to do you're taxes you've got it all wrong. File the extension and wait for the next model release to do your taxes for you. You're welcome

Carta has hands down the best hold music. I'm groovin with support here

@gracepace_ @AnnieLiao_2000 Is this AI

I became an ABG CMO. Thank you @AnnieLiao_2000 for the transformation! This is my first time trying makeup, what do you all think?

Here is what will (likely) soon happen: All compounded and gray market GLPs (reta. and priors) will be highly illegal to sell… meaning any sites carrying these will be uniformly shut down. Other peptides will remain available. This is just a prediction but I’ll take any bet.

BREAKING: The CDC just released new data that should alarm every parent in America: 1 in 3 teenagers now has prediabetes. Prediabetes is diabetes and it is reversible. All that sugar is adding up.... gis.cdc.gov/grasp/diabetes…

@gracepace_ @DsgnBuddies @zocomputer @buildclub_ let's go! can we bring other founder friends?

who is in san francisco on feb 16? we hosting an epic lunar new year party with @DsgnBuddies @zocomputer @buildclub_ with the best creators, founders, and builders in SF! comment below if you want a link to join~