Jacob M. Hands

@TuckerGoodrich @trikomes @OmegaQuant Sorry to disagree w him — the health risk is overstated, but the answer is even after adjusting for flavoring, mean TOTOX is exceeded in 13-63% of sample, but sure if improved, see iFOS, consumerlab.com.. also, flavor used to deceive pubmed.ncbi.nlm.nih.gov/37712532/

@trikomes @OmegaQuant @jacobmhands ?

According to Dr. Bill Harris from @OmegaQuant, the apparent rancidity here may be due to flavorants increasing false positive rates. He said rancidity risks are overstated for omega-3 supplements (which he sells). Anyone out there have good independent verification of this?

@Madam_Mito @paulsaladinomd Thanks for this interesting read

@jacobmhands @paulsaladinomd nature.com/articles/s4159… Check this Jacob ✨

Public service announcement: the question of whether or not supplemental fish oil can cause damage has largely been studied — see Ottestad 2012 (also 2013) in an rct of FO, Oxidized FO and Sunflower Oil ABSOLUTELY NO DIFFERENCE in any inflammatory marker! oda.oslomet.no/oda-xmlui/bits…

@Rom6233 @paulsaladinomd @PhD_Leigh @Madam_Mito This means it’s not even a question that if you do a trial — fish oil against fish consumption — on major adverse outcomes, it is obvious in most aggregated studies that fish consumption is better, maybe theoretical benefit to fish oil over fish but haven’t seen yet

@jacobmhands @paulsaladinomd @PhD_Leigh @Madam_Mito I have wondered if even this is true "fish is always a superior source obviously" I mean, you get the salmon, season, cook it a few minutes, cut it up, and then take several minutes to eat it all It seems like the fish has much more opportunity to oxidize

You Are Being Lied To About Fish Oil

@Rom6233 @paulsaladinomd @PhD_Leigh @Madam_Mito There is limited evidence that fish oil, rancid or not, can cause significant harm, particularly in the short term. Also, most oils now on the market especially those that are USP, iFOS are safe. Don’t be scared of fish oils. Yes, fish is always a superior source obviously

@jacobmhands @paulsaladinomd @PhD_Leigh @Madam_Mito Do you believe Sal is right? Many liquids are available, can we not taste if spoiled and just take with vitamin E? Krill and some cod oil come with Astaxanthin

@Madam_Mito @paulsaladinomd Incredible I wish @paulsaladinomd would invite our lab on for a few minutes (way better to have Bill Harris) — the thing is I think he just doesn’t know the data and has never had anyone who publishes on this discuss the data in real time not hard to fact check

@paulsaladinomd Check this out @jacobmhands <<oxidation in our tissues>> Why is everyone so very dumb.

What is the clinical evidence to support off-label rapamycin therapy in healthy adults? 👉"This paper has reviewed trials of low-dose mTOR inhibition therapy in human subjects. What emerges is a complex picture that remains insufficient to affirm or negate the longevity and healthspan extending benefits attributed to rapamycin." @jacobmhands @mike_lustgarten @PhD_Leigh @DrBradleyRosen1 | @AgingJrnl aging-us.com/article/206300…

Association of Common Foods with Inflammation and Mortality: Analysis from a Large Prospective Cohort Study pubmed.ncbi.nlm.nih.gov/38354278/

6. We need to personalise blood test ranges An individual's ranges are much more narrow than the 'normal' reference range And when the numbers change - even when they're within the reference range - it alters disease risk and survival outcomes nature.com/articles/s4158…

4. A common inherited variant increases cholesterol levels and reduces survival in breast cancer The PCSK9 variant, A/A (V474I), is present in ~70% of Europeans In mice, blocking PCSK9 reduced breast cancer metastasis (and cholesterol levels, too) cell.com/cell/fulltext/…

Biggest medical discoveries of the week (🧵) 1/8 Treating pre-eclampsia by sprouting new blood vessels Delivering VEGF to the placenta (intravenously, via placenta-tropic mRNA nanoparticles) resolved high blood pressure and birth weight (in mice!) nature.com/articles/s4158…

Worried about omega-3 supplementation? Listen to this #podcast and read our review on the science behind omega-3 supplements & why studies are conflicting or null: esmed.org/MRA/mra/articl… Also, our study on rancidity in omega-3 supplements: tandfonline.com/doi/abs/10.108… @jacobmhands

The anti-aging impact of metformin (randomly assigned, with controls) in male monkeys after 40 months of treatment, a pan-omic clock assessment —~6 year regression of brain aging, with prevention of atrophy and enhanced cognitive ability —minimal effect on blood sugar —evidence for multi-organ decelerated aging cell.com/cell/abstract/… @CellCellPress

@actem_care @lipo_fan @JohnKastelein @OxPL_apoB More large HDLp better cholesterol uptake in peripheral tissues that gets recycled back to the liver less CHD supposedly

Great analysis of HDL-p size and CHD risk with and without DM Large HDL-p often associated with protection, though smaller HDLp doing most of the efflux — strikes me as strange because large should be doing uptake in periphery — question for @lipo_fan @JohnKastelein @OxPL_apoB

@JohnKastelein @lipo_fan @OxPL_apoB Fascinating so basically you would argue that given low large HDLp your concern is not so much CHD but actually CETP related issues? Also, if ApoE mediated shouldn’t ApoE4s have many, many large HDL because binding is too tight and thus not recycled?

@jacobmhands @lipo_fan @OxPL_apoB It is not the small HDL , but the ultra small HDL ( prebeta HDL , nascent HDL , lipid free apoA1 ) that are key for ABCA1 driven chol efflux . Larger HDL are apoE rich and cleared through LDL recs and SRB1 and signal efficient liver uptake of excess chol acquired in periphery

Mice with "mitochondrial disease" caused by an OxPhos complex I defect are healthier and live longer if they are intravenously injected with mitochondria Are circulating mitochondria a source of resilience for the organism? Important work @BrestoffLab nature.com/articles/s4225…

@ImageOcclusion @JayKurtz90 @JaredMichaels17 @exosome @yeeseak @Physionic_PhD @JuliaB_fitness @jacobmhands twitter.com/jacobmhands/st…