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What is the cardiovascular significance of adipose tissue surrounding the heart? Our study, published in @JAMACardio today, asked this question: jamanetwork.com/journals/jamac….
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Joel Rämö
366 posts
Joel Rämö
@joeltramo
MD,PhD • Medicine Resident @BrighamMedRes • Genetics & cardiovascular research @broadinstitute & @helsinkiuni • Perennially searching for a sauna in New England
Boston, MA Katılım Kasım 2017
1K Takip Edilen417 Takipçiler
Joel Rämö retweetledi
VITAL-AF was a negative RCT...1L ECG screening in primary care did not ⬆️ #afib diagnosis.
But IF we used ECG-AI to guide screening, could it have gone differently?
Our new analysis @JACCJournals led by ⭐ fellow @nat_ved sheds light into the potential future of #afib screening
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Joel Rämö retweetledi
We know too much sitting is harmful. But just how bad is it??
New @JACCJournals #Advances work led by ⭐ @MGBResearchNews #EPeeps fellow @AjufoEzim quantifies effects of measured sedentary behavior on >700 future diseases
@uk_biobank @broadinstitute @MGHHeartHealth @MACE_Lab_AI
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Joel Rämö retweetledi
Our new genetic study of aortic stenosis in ~3M led by @AeronSmallMD & w @ThanassoulisMD uncovered 241 genome risk regions. These may lead to new targets for medicines, as no effective medicines currently exist. nature.com/articles/s4158… @NatureGenet
[1/11] 🧵
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Joel Rämö retweetledi
We’re excited to share our new Nature Genetics paper examining the genetic architecture of aortic valve function and aortic stenosis. We used deep learning of cardiac MRI and MTAG to study disease biology long before clinical diagnosis.
nature.com/articles/s4158…
1/10
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Joel Rämö retweetledi
It’s my most privilege to work with such great mentors @shaan_khurshid, @aklfahed, @patrick_ellinor and brilliant minds @ShinoKany @tigerstatdoc @joeltramo, and many more!
Looking forward to the expansion of clinical use cases for proteomic data😀
Shaan Khurshid@shaan_khurshid
Check out our new analysis @Circ_Gen led w/ @MinSeoKim_MD on an #ML-based proteomic score to predict future #afib ! Link + highlights below ⬇️ @MGHHeartHealth @broadinstitute @patrick_ellinor @aklfahed
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Joel Rämö retweetledi
Now on medRxiv, we explore the genetic similarity between dilated cardiomyopathy (DCM) and peripartum, alcohol-induced, and cancer therapy-related cardiomyopathies (PPCM, ALCM, CCM).
Led by star trio @DimitriMaamari, @kiranbiddinger, and @JurgensSean.
medrxiv.org/content/10.110…
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Joel Rämö retweetledi
Is the ECG secretly a sphygmomanometer? We trained a neural net to predict hypertension from ECGs and found it associated with many cardiovascular outcomes.
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Joel Rämö retweetledi
Delighted to share our study led by @Harvard undergrad @akshayaravi22 with @broadinstitute postdoc @skoyamamd describing a general inverse genetic relationship between LDL-C and incident T2D. jamanetwork.com/journals/jamac… @JAMACardio
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Joel Rämö retweetledi
Just how many diseases can you identify with a good old 12-lead #ECG?
NEW @npjDigitalMed, co-led w/ @lucidtronix, @RVpacing & @xwang, we use an autoencoder to map ECG to phenome, finding associations btwn ECG & >600 conditions @broadinstitute @broad_ml4h @MGHHeartHealth
LINK⬇️
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Joel Rämö retweetledi
Is slow heart rate or conduction block heritable?
Check out our new meta-analysis @NatureGenet incl common (~1.3m individuals) + rare (~400k) variants for bradyarrhythmias and conduction dz. Co-led w/ @LuChenWeng @joeltramo @JurgensSean @broadinstitute !
nature.com/articles/s4158…
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Joel Rämö retweetledi
#ICYMI: Rare Genetic Variants, LDL-C and Aortic Stenosis @jpirruccello @joeltramo @broadinstitute @MGHHeartHealth @UCSFCardiology @patrick_ellinor @shaan_khurshid @joeltramo @JurgensSean @ShinoKany @mahnazmaddah
Circulation@CircAHA
#SimPub #CircESC2024 Lifelong LDL-C levels, driven by rare genetic variants, significantly influence aortic stenosis (AS) risk. Findings suggest that early & sustained lipid-lowering therapy could be key in preventing AS. ahajournals.org/doi/10.1161/CI…
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Joel Rämö retweetledi
We went on to perform Mendelian randomization, to find causal risk factors for DCM through genetics 🧬
We identified several potential causes of DCM, including AF, bodyweight, height and SBP
with bodyweight and SBP remaining as independent and robust causal risk factors ♥️➡️❤️🔥
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Joel Rämö retweetledi
What is the role of common genetic variation in dilated cardiomyopathy (DCM) 🧬
and what causal pathways underlie the disease? 🫀
Happy to share our GWAS for DCM, published last week in @NatureGenet
nature.com/articles/s4158…
@amsterdamumc @broadinstitute
A detailed 🧵below:
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Joel Rämö retweetledi
In @NatureGenetics, our international team delivers a GWAS of dilated cardiomyopathy (DCM) - major cause of heart failure/transplant - led by @JurgensSean, @joeltramo, et al., with key leadership from @patrick_ellinor, @dalygene, @cbezzina1, and others.
nature.com/articles/s4158…
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@pnatarajanmd @patrick_ellinor @MassGenBrigham @MassGeneralNews @BrighamWomens @MGHHeartHealth @bwhcvls @MGHMedicine @MassGeneralMDs @broadinstitute @harvardmed Huge congratulations @patrick_ellinor !! I cannot imagine a better leader for the institute.
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Joel Rämö retweetledi
Incredibly excited that my friend & colleague @patrick_ellinor is the new Executive Director of the @MassGenBrigham Heart & Vascular Institute!!
@MassGeneralNews @BrighamWomens
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@eemoin @AllofUsCEO @American_Heart @AllofUsResearch @uk_biobank Thank you Emily! This was jointly done with the stellar duo @JurgensSean and @ShinoKany
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Joel Rämö retweetledi
Deep dive on #EARLYTAVR from ##TCT2024
Lots already said & discussed
It takes time to read the paper, read the supplementary appendix, analyse the results, think about them etc!
Some thoughts...🧵
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@Chris123_1123 @CircAHA @uk_biobank @AllofUsResearch @JurgensSean @ShinoKany @patrick_ellinor @jpirruccello Thanks! That's a good idea to aid follow-up studies. Unfortunately, we didn't list rsIDs in the published manuscript (as we lacked statistical power to evaluate single variants). As one workaround, UKB allele frequencies & AlphaMissense predictions for all variants are public.
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Is LDL-C a causal risk factor for aortic stenosis? We're excited to see our study now in @CircAHA examining this question by leveraging rare protein-disrupting variants in @uk_biobank and @AllofUsResearch. With @JurgensSean, @ShinoKany, @patrick_ellinor & @jpirruccello.
Circulation@CircAHA
#SimPub #CircESC2024 Lifelong LDL-C levels, driven by rare genetic variants, significantly influence aortic stenosis (AS) risk. Findings suggest that early & sustained lipid-lowering therapy could be key in preventing AS. ahajournals.org/doi/10.1161/CI…
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Joel Rämö retweetledi
Exercise is beneficial for health. But many people have to cram their activity into 1-2 days/week. Do they still get the benefit?
To find out, we looked at associations of "weekend warrior” (WW) physical activity) and >600 diseases, now @CircAHA !
A 🧵
ahajournals.org/doi/10.1161/CI…
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