Patrick Joyce

The @ResearchHubF is starting to see results from our initial experiments into funding preregistrations 💜💪🔬

Is this a mirage?

Important preprint (with awesome figures!) showing monocytes are biological sensors of aging and frailty in humans by the @JudeM_Phillip lab from Johns Hopkins @JHUBME. researchhub.com/paper/11126914…

You can now buy or deposit $RSC directly into your ResearchHub wallet. researchhub.com/researchcoin

>200 million people have peripheral artery disease (PAD). In its worst form, blood vessels fail to regrow after surgery. Wounds stay open. Muscles waste. @HaoYin20's preregistered proposal just received $10k to study the pathology of PAD on ResearchHub. 🧵

Super happy that we could fully fund this great proposal by @HaoYin20 with @ResearchHubF on Sirt6 Deficiency in Microvascular Mural Cells as a Driver of Paracrine Senescence and Impaired Regeneration. Looking forward to seeing the results. Check it out here and let’s support open science: researchhub.com/proposal/5526/…

Truly appreciate the support of ResearchHub @ResearchHubF @ResearchHub @rust_ruslan 🙏🙏🙏 For so many years, this is my FIRST grant submitted & FUNDED!!!🥹 Pickering lab is now ready to continue our NAD+-Sirt6 adventure into microvascular zone🤠 Also thank @DocJasonLee for the powerful & beautiful preliminary data🙌 👉Can microvascular mural cells orchestrate the vascular & muscular regeneration following ischemic skeletal muscle injury? 👉Can senescence be propagated from one cell type to another in ischemic muscle? 👉Can we design a therapeutic strategy, such as NAD+ supplementation or Sirt6 activation, to prevent tissue damage/failure in peripheral artery disease? Please take a look at my grant, and any advice/suggestions are highly appreciated! researchhub.com/proposal/5526/…

🧵 Today we released a new preprint on @ResearchHub and opened it for public peer review. Our team explored how cannabis-derived therapies influence gene expression in a Drosophila model of ALS using RNA sequencing of fly brains. Here’s what we found ↓

That’s very exciting 🤩 Someone has just put $200,000 on the table to scientifically prove (or disprove!) my little stone softening experiment in a pot WITH REAL SCIENCE! 🧪 Grab it! It’s for you! I’m not a scientist and I don’t even pretend to be one, so this amount is for YOU, the real SCIENTIST with pedigree and such. Let me quote the announcement: “A $200K funding opportunity was just posted on @ResearchHub to capitalize experiments testing a decades-old hypothesis: That ancient megaliths weren't carved from quarried stone — they were cast from geopolymer concrete” Use this repost of mine and scroll up in the thread to find the juicy details:

I just funded: A Parallel 3D-MEA Closed-Loop Chemogenetic Platform to Restore Network Computation in Disease-Modeled Assembloids on @ResearchHub! researchhub.com/fund/16629/a-p…

Stop by in 10m if you’re interested in chatting about prediction markets for science!

In 2026 @ResearchHub is focused on building a tool that helps scientific funders get the best possible ROI on their research capital Stay tuned to see a bunch more RFPs like this fascinating one exploring ancient engineering practices

Founders, @BoostVC is investing heavily in New Bio and Longevity. Please reach out if interested. $500k first check investments.

I just funded: “Network Analysis of Neural Subsystems to Assess Consciousness, Cognition, and Ethical Implications” on @ResearchHub researchhub.com/author/8573774…

Great preprint on sex-specific regulation of endothelial-to-mesenchymal transition during atherosclerosis. This work has an average score of 3.5 out of 5 from our peer reviewers. From preprint to public peer reviewed research in less than one month. That should be the standard for science in 2026 @ResearchHub researchhub.com/paper/11081108…

Polymarket showed markets can predict elections better than polls. Now they’re coming for science. At the Quantum Biology DAO, we explore new mechanisms for discovering and funding scientific truth. Markets are already forecasting replication, credibility, and research outcomes. Next: funding science itself? Join us next Wednesday, March 4th, for an X Space at 3:30pm ET | 12:30pm PT to discuss. With: Thomas Pfeiffer (Prof. Computational Biology) Patrick Joyce (Co-founder of ResearchHub) Geoff Anders (Co-founder of QBio DAO)

Exercise is known to lower dementia risk. But how exactly? This preprint shows that aerobic activity may strengthen the brain’s smallest blood vessels. Making them more resilient during aging and early Alzheimer’s pathology.

Brain organoids are mini-brains grown from stem cells and they are one of the most exciting new tools in neuroscience. But they have a critical flaw: they lack the spatial organization of a real brain. This proposal on ResearchHub wants to fix that.🧵

Just funded a pilot study looking into whether chronic low-frequency EMF exposure weakens tendons and makes them more prone to injury Led by Prof. Chi Hwan Lee and his team at Purdue! researchhub.com/fund/5468/chro…

I just funded: Engineering Morphogen Gradients to Grow Larger, Spatially Patterned Human Cortical Organoids on ResearchHub! Such a cool project, check it out @jdpereira researchhub.com/fund/7659/engi…