@Neuroscope_mp My bet is that this is not "immune reset." I think it's more likely clearing the EBV reservoir in autoreactive b cells.
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Kyle
6.1K posts
Kyle
@klmatter
Engineer, father, and avid outdoor enthusiast. Current dealing with post viral illness/long COVID. Trying to fix that last one.
Canada Katılım Mayıs 2022
576 Takip Edilen685 Takipçiler
THE BIGGER PICTURE
And lupus may just be the beginning.
CASTLE already tested three diseases.
Researchers believe the same approach could work across:
🔬 Myositis
🔬 Systemic Sclerosis
🔬 Multiple Sclerosis
🔬 Severe Rheumatoid Arthritis
🔬 Possibly other B-cell driven autoimmune conditions
Same principle. Corrupted B-cells.
Same reset.
The immune system is more reprogrammable than we ever thought.
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🚨 BREAKING:
German researchers treated 15 severe lupus patients with CAR-T therapy.
All 15 went into complete remission.
Many stopped ALL medication.
Now a larger trial just confirmed it — across 3 autoimmune diseases.
This might be the biggest shift in autoimmune medicine in decades. 🧵
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@Aguirre1Gustavo @anna_reise87030 Appreciate the added context and explanation. Thank you. I started out thinking I had long COVID but a lot of the evidence is now pointing to a Bartonella infection.
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This is not a typical lesion, but this may be because you are not significantly immunocompromised.
If, when pressed with a finger, it turns whitish—that is, if the reddish color disappears upon pressure—this gives us the clinical diagnosis of vascular compromise with persistent inflammation that increases blood flow, which is what occurs in persistent Bartonella infections.
Considering that in approximately 90% of patients with Long COVID, at least one pathogenic microorganism is identified in the Peripheral Blood Smear (mainly persistent zoonoses), we recommend that you have this test performed by an experienced physician. In Appendix 2 of the linked document, we detail how to have a Blood Smear performed by an expert physician:
researchgate.net/publication/39…
x.com/Aguirre1Gustav…
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BARTONELLA STRETCH MARKS (STRIAE) IN:
ME/CFS, LONG COVID, LYME,
AUTOIMMUNE, NEUROLOGICAL, AND PSYCHIATRIC DISEASES.
Persistent Bartonella infection can cause linear, reddish skin lesions, darker than the surrounding skin, that resemble stretch marks.
They frequently appear on the extremities, back, or abdomen.
If a patient with ME/CFS, Long COVID, Chronic Lyme, or other chronic illnesses with neuropsychiatric symptoms (anxiety, depression, anger, panic, OCD, headache, brain fog) has these stretch marks or “Bartonella striae”, a Peripheral Blood Smear and blood tests should be performed to confirm Bartonella infection.
Babesia and other persistent infections may coexist with Bartonella, as detailed in several of our publications:
researchgate.net/publication/39…
researchgate.net/publication/40…
If you don't have these lesions, it doesn't mean you don't have Bartonella, since about half or slightly more of people don't develop them.
In addition to stretch marks, persistent Bartonella infection can produce reddish nodules or papules, which are vascular proliferations known as Bacillary Angiomatosis.
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@Aguirre1Gustavo @anna_reise87030 Would you consider this one? Emerged on a stretch mark after taking low dose rapamycin once a week for a few months. Has persisted for like 7-8 months and counting.
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@DrRogerHugh Idk how so many doctors can be so unintellectually curious about Lyme, Bartonella and Babesia.
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Exactly. Imagine all the executives and employees who know their companies poison Americans, but at least they make a nice salary and can live a life of luxury. Diffusion of responsibility. Not to mention physicians get wealthy off the sick so it is encouraged.
Toby Rogers@uTobian
The U.S. is afflicted with an epidemic of cowardice. Scientists are cowards, doctors are cowards, regulators are cowards, politicians are cowards, reporters are cowards, professors are cowards, C-suite executives are cowards. Cowardice is the defining feature of the Covid crisis.
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Thanks to community support during our family emergency, today was a grateful in-person return to Capitol Hill. As first #LongCOVID org to join Defense Health Research Consortium, @LCCampaign met w/key bipartisan Senate staff to request Long COVID CDMRP funding. #WeCarryEachOther
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@seanstidston @ErinSandersNP @RanaAwdish @WesElyMD @DocZing @MDaware @resiapretorius @PutrinoLab @dbkell @sunsopeningband @JanetDafoe It wasn't great but it was actually a big clue. It was the first piece of evidence that I might have Bartonella.
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@klmatter @ErinSandersNP @RanaAwdish @WesElyMD @DocZing @MDaware @resiapretorius @PutrinoLab @dbkell @sunsopeningband @JanetDafoe How did this go Kyle ?
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Not doing so well physically, but trying to optimize my health until my mastectomy and reconstruction in October.
I wanted to share this paper more widely because it really has the potential to improve quality of life for a lot of chronically ill folks:
patientresearchcovid19.com/hypothesis-mat…
Erin C. Sanders, MSN, WHNP (She/Her)@ErinSandersNP
Such an awesome initiative by @patientled that I was thrilled to support! Huge TY to Dr. @tessfalor, @LisaAMcCorkell, @ahandvanish, Mihaela Suleap & all the patients who submitted!🙏 cc: @WesElyMD @RanaAwdish @tmprowell @GermHunterMD @PutrinoLab @doctorasadkhan @resiapretorius
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@raghu_venugopal @22_Minutes If you don't think there's a lot of truth in this video then maybe you're part of the problem. Satire is part of the political process and helps affect change. Clearly our healthcare system needs to change.
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Shame on you. On behalf of every real ER doctor and nurse who's struggled with overcrowding and long wait times, and on behalf of every Canadian and their family who's suffered the inadequacy of our ERs at times. I'm a huge CBC fan. You disgust me. @22_Minutes
This Hour Has 22 Minutes@22_Minutes
Welcome to The Peg. 🩺
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@hutch_golf Why do you need a device if there's no sensors? An iPhone chip is literally powering Apples new laptop.
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In my time at Arccos, this is the thing I’m most proud of having contributed to.
Tracking your shots without needing sensors on your clubs is a wild technical challenge. I can’t tell you how many versions of this we built over the last several years before we felt we had it right.
A couple clarifications…
- iOS only (for now)
- New members can use the link I shared below
- Existing users with a Link Pro / Air device can just take the sensors off your clubs and you’ll be good to go
- In your settings, you can ask AI to auto tag your clubs or you can manually do it if it’s important to you. Strokes gained doesn’t care what club you hit.
Lmk any questions!
Arccos Golf@ArccosGolf
Introducing Arccos Air. ✨🏌️♂️ Tracking your game just got a whole lot easier! We have spent years listening to golfers tell us the same thing. The data is powerful. The sensors are ... well sometimes we love them and sometimes we don't. They want the insights without the friction. Arccos Air is exactly that. No phone. No sensors. Just golf. A pocket-sized AI wearable that automatically tracks every shot of every round with no sensors on your clubs and no phone in your hand or pocket. Powered by AI trained on 1.5 billion golf shots, it delivers Strokes Gained Analytics, AI Strategy, and Green Maps to help you play your smartest golf. Play a rental set. Switch clubs mid-season. Arccos Air tracks your game no matter what. Available now. 🔗 Shop Arccos Air: Arccosgolf.com
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@NIHDirector_Jay @Ayjchan Would love to see one on chronic Lyme disease.
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🔬Scientific progress depends on discovery, but also the freedom to question, debate, and examine evidence wherever it leads.
In the spirit of that ideal, I’m thrilled to announce the launch of our NIH Scientific Freedom Lecture Series, an exciting new forum aimed at advancing transparency, rigor, and open scientific inquiry.
Please join me March 20 at 2:30pm ET for our inaugural talk, titled “Viral: The Search for the Origin of COVID-19” featuring a conversation with Matt Ridley, D.Phil.
Guests can attend in person at the Masur Auditorium in NIH Building 10 or online via the NIH videocast page. bit.ly/3PsHAu5
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Instead of arrogantly demanding the publisher of this chart post their "code on GitHub" - I went and pulled the data and re-created the inflections myself.
This is how it is done. Something our pretend analysts consistently show they cannot do...
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@danaparish I was the opposite of a conspiracy theory guy not that long ago but stuff like this really makes a person think 🤔🤔🤔. It's not a conspiracy if it's true.
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@craigvn @IWONSOWAT @LouStagner If the putt has break now you're testing green reading and not the putter head. There's a very good reason to limit variables.
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What is the skill level of the testers? How many testers? What surface did they putt on?
Most of the make rates you listed from the test group are better than pga tour average make rates.
MYGOLFSPY@MyGolfSpy
Blade vs Mallet Putters — What the Data Actually Says We analyzed 43,000+ putts using our algorithm and the @PuttView testing system to answer a simple question: Do mallet putters outperform blades? Short answer: Yes. And it’s not particularly close. Here’s what we found 👇 1️⃣ Overall Performance 2.6 stroke advantage for mallets. And it wasn’t just one or two golfers skewing the results. (85%) testers putted better with a mallet.
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I wish every physician understood how massive the tick-borne infection crisis is. It's more shocking than if aliens landed tomorrow.
Too many "chronic conditions" are just untreated tick-borne symptoms in disguise, wrong meds, endless suffering.
Physicians are clueless.
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@fidjissimo @amyrochlin @CODA_research Thanks for all of your support, @fidjissimo. You've been a huge force moving the field forward.
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So grateful to @amyrochlin and the @CODA_research team for all they’re doing to advance research for the tens of millions of patients dealing with neuroimmune conditions. Every day I open my feed to amazing news of medical breakthroughs or other longevity magic, yet they stand in sharp contrast to all the tweets I see from patients who are bedbound, fighting for their lives, with not a single cure in sight. These debilitating diseases are sidelining millions and as a society, we are failing these people. We need to do better.
Amy Rochlin@amyrochlin
Long Covid has pushed the scientific community to address something medicine has struggled with for decades: complex chronic illness that affects multiple systems at once, often impacted by impaired Neuroimmune crosstalk. I appreciate the framing from two years ago, but we can no longer remain in this place of terms and definitions. Patients Can't Wait. They are suffering in ways that are truly indescribable. Endless pain, inability to get out of bed, painful digestive issues that put them in the ER on a regular basis. Enough is enough. We are now at a point where data, technology and neuroimmune science are converging and can move forward rapidly for patients: to determine biological subtypes, identify measurable biomarkers, and establish clinical endpoints that reflect the underlying physiology of patients - not one size fits all approaches. What is missing? I'm going to say it. FUNDING. Without serious investment and support from the philanthropic community, progress toward diagnostics and treatments for Long Covid and related conditions such as ME/CFS, chronic migraine, IBS, and others will continue to stall. Please consider donating to @CODA_research or to other high-quality research organizations today! Let's come together as patients and demand more. #LONGCOVID #MECFS #POTS #MIGRAINE #SJOGRENS #EDS #MCAS #CHRONICPAIN #FIBROMYALGIA #ENDOMETRIOSIS #IBS #GATROPARESIS #NEUROIMMUNE #PATIENTSCANTWAIT #LONGCOVIDAWARENESS
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The thing buying a co2 monitor taught me is that the obsession with insulating and sealing houses is psycho. You actually want a window cracked 24:7.
The solution to climate change isn’t hotboxing in 2000ppm co2: it’s window open + AC / Heat On powered by abundant electricity.
Chris Lakin@chrislakin
>wake up with a mild sense of doom >check CO2 meter — 1400ppm >ah
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It's Long COVID Awareness Day. Americans are still grappling with COVID’s repercussions, including Long COVID. I'll keep working to support research and education on this condition and other infection-associated chronic conditions.
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@microbeminded2 @polybioRF Thanks Dr. Proal for all of your research and advocacy!
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So glad to join today’s HHS #Lyme & Invisible Illness panel! Via @polybioRF we are validating novel diagnostic tests to identify chronic infections missed by current bloodwork. These diagnostics will help make the invisible visible in Chronic Lyme, Long COVID & related conditions
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@leadlagreport Being years early isn't right. Neither is making the same proclamation everytime the market dips 1 or 2%.
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Reverse carry trade still gonna fuck you all up fam.
Am right about private credit.
Am right about Japan.
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