Fakun Cao

@mtaylor_Berlin @purbakashyap @N_A_Srikanth @kunkunbiodog Thank you @mtaylor_Berlin , @N_A_Srikanth and @kunkunbiodog for an incredible collaboration. From a cold start to submitted data in a few weeks. Such convincing data on an exciting system. To the next one!

Meet @kunkunbiodog, postdoc in the @mtaylor_Berlin lab. Here, she is about to unravel the mystery of signal transduction in inflammation with her favorite buddy TIRF microscope 🔬. #PAW_Germany #PostdocAppreciationWeek

In sum we found IL-1-induced NF-kB activation occurs in condensed subcellular structures organized by Myddosome, containing Ub machinery, IKK and p65. Cells read out IL-1 amount, turn on NF-kB activation via single Myddosome, and amplify responses by Myddosome clustering. 8/8

With higher IL-1 density, we increased the number of Myddosome clusters per corral on gridded SLBs. This concentrates more TRAF6 and rescues HOIL1 recruitment. 7/8

Our latest work @mtaylor_Berlin about Myddosome clustering drives digital and analogue NF-kB responses is now available on EMBO Rep. Check it out😊. A thread... 1/8 embopress.org/doi/full/10.15…

@xiangyi_susie Thanks! Same to you. Congrats on your new publication 🍾️🍾️🍾️🦾🦾🦾

@kunkunbiodog Great start to a year! Congrats!

Very excited to share our latest work in the first week of 2023🥳 Check out to see how Myddosome clustering and ubiquitin machinery produce digital and analogue IL-1R signaling. Thank @mtaylor_Berlin and all in the lab for making it happen! #Myddosome #Ubiquitin #TRAF6 #LUBAC

We have a PhD position! This is a very cool interdisciplinary project and you will get to work with great collaborators. Join us to examine the life cycle of immune signalling condensates! DM or email if interested. More info in the link below.

Amazing first night at the GRS/GRC #GRCBiointerfaceScience! Great science, great company!

Have a great year of the Tiger 🐯

Ester linkages are an emerging theme in #ubiquitin signaling as well as in commentaries that @rbdamgaard and I write. In @FEBSJournal we discuss recent work linking Ub esterification to immune signaling and contextualize these findings with other examples. onlinelibrary.wiley.com/share/author/P…

First lab publication out now in @JCellBiol. Congratulations to the first authors @RHDeliz and @kunkunbiodog! Keep a 👀out for the next work from those two! Also shout out to @ReviewCommons for a constructive and smooth peer review process and transfer to JCB.

My Xmas and new year gifts 🙈🙈🙈🐒🐒🐒

Just over 24 hrs before innate immunity officially debuts at #cellbio2020🥳🥳 @MajerOlivia, Jean Scholz and I will be hosting Innate Immunity across Systems session tomorrow Dec 11 @ 7:45 pm CET!!!

Our first paper from the lab @mpiib_berlin is now out on @Biorxiv! This was a whole lab collaborative effort with special kudos to first authors @RHDeliz and @kunkunbiodog. In this work, we directly visualised the molecules that control inflammation. A thread... 1/11