David Kuppermann MD

@FocalOneHIFU @dfrendl @MayoClinic ❤️

Join Daniel Frendl, MD, PhD (@dfrendl) from @MayoClinic at the Focal One Masterclass in Robotic HIFU during #WCET25. His presentation will discuss the role of focal therapy in prostate cancer care, focusing on patient selection, the role of the most recent diagnostic tools and how to launch and grow a successful focal therapy program. September 10 at 10:00 AM | Phoenix, AZ Register now – limited space available: events.focalone.com/wcet25-hifu-ma… #HIFUmasterclass | #ProstateCancer | #RoboticSurgery | #Urology | #MedTech | @Endo_Society | @FocalSociety | @SocietySURS

@BEkidneystone Congrats 🎊🎉

@FarroYossi @USPS @grok is this true?

The @USPS confirmed that the Lubavitcher Rebbe received more mail than anyone except for the President. The Rebbe personally opened each letter bec some of them were sealed with the actual tears of the writers & he could not open a letter sealed with tears by using a machine.

@jeshoag @giladevrony Great work @jeshoag @giladevrony

New paper from my group and @giladevrony’s! nature.com/articles/s4146… Historically we measured new mutations in humans using trio studies (parents and offspring). This taught us that on average new mutations increase in offspring with paternal age. These trio studies showed that mutations in sperm account for 80% of new mutations in humans! These are responsible for our genetic diversity and many genetic diseases. But these studies measure population averages rather than the rate of mutations in individual men. To address this, we recalled men who had banked sperm from an average of 19 yrs ago (up to 33 yrs)- to provide a new sperm sample. Applying recent advances in DNA duplex sequencing and whole-genome sequencing to these paired samples, we measured a mutation rate for each man. Mutational patterns seen by direct sperm sequencing matched incredibly well to prior trio studies. And in two men, we found that mosaicism of embryonic mutations hardly changed in sperm with age, indicating remarkable stability of spermatogonial stem cell pools over decades. We thank our amazing collaborators and funding from @NICHD_NIH. See also exciting recent preprints by @R_Rahbari and @aaronquinlan!

If I could go back in time I would take advantage of this opportunity. Great research, great mentor, great work environment! @BEkidneystone

@LahavHarkov @bendreyfuss Liberty hotel in Boston?

@bendreyfuss I once stayed in a hotel that used to be a prison and had the multiple floors flush against a rectangle layout. It was a nice hotel...if you didn't think about it too much.

In movies, there are two types of prison layouts. (It’s possible the second one is for jails and not prisons.) It seems obvious that the second one is better. You can see all the cells from one guard location in a Jeremy Bentham Panopticon-ish way

@MGHUrology Congrats!

Great time celebrating at the farewell dinner for our chief resident, Gordon Lu, PGY-6. Good luck on all your future endeavors Gordo, we can’t wait to hear about your next chapter!

Best part of conferences is hanging out with your residency family ⁦⁦@MGHUrology⁩ ⁦@therapy_focal⁩

@jfunkmd @CanesDavid @daviesbj @uroegg @JChipMD @urogeek @UroOnc Depends on size of prostate. If very large targeted plus “penumbra” I e perimeter around the target. If not too large systematic + target

60-ish yo male. Elevated single digit PSA. Prior standard template biopsy 5 years ago negative. mpMRI shows PIRADS 4 and a PIRADS 3 lesion. @CanesDavid @daviesbj @uroegg @JChipMD @urogeek #UroSoMe @UroOnc

@MGHUrology Don’t miss the opportunity to learn about a great program with autonomy and wide breadth of pathology!

Come learn more about our program at tomorrow's open house (7 PM E.S.T.) See the below post for sign up details Looking forward to seeing everyone there!

@uro_nima 👏 🤩

Immunological tolerance to liberate patients from immunosuppression after a kidney transplant… more to come! #section-3d6acba1-acea-4be2-8dc9-b7e14e5b6583" target="_blank" rel="nofollow noopener">thelancet.com/journals/lance…

Nice work by ⁦@uro_nima⁩ goldjournal.net/article/S0090-…

Congrats to our 2022 Resident and Fellow graduates @dfrendl @kuppermann, Dr. Twum Ampofo, Dr. De Carvalho and Dr. Nayan as well as our faculty award recipients Dr. Dyer and Dr. Wintner! Wonderful to celebrate with you in person !

@kjdelay1 Yes

Tinder Swindler: Watch or no?

@AshleyGWinter @CatDocMD My yarmulke gives it away 😛

@CatDocMD I just say, "We aren't here to talk about me 😊," that usually ends it. Although one time I had a patient who was on his 3rd separate attempt at telling me accepting Jesus could save me from burning in hell for eternity & and I just went ahead I was Jewish - un-saveable

Always a blast when everyone gets together! Happy #AUA22 @MGHUrology family! @AFeldmanMD @BEkidneystone @KeyanSalari @TammerYamany @sarahmorazz @urochiefmlb @DMDahl

@justindubinmd Where can you get those pins?

There are some really incredible pins at #AUA22 My personal favorite (and my go-to trivia team name) is Urethra Franklin 😂

@AsishanaOsho @MGHSurgery @mghctsurgery @mgh_transplant

A conversation with Drs Thor Sundt and Asishana Osho youtu.be/YWt7xLOFkhM @MGHSurgery @mghctsurgery @mgh_transplant

@MGHUrology Highly recommend this opportunity. Great program with excellent training in all areas of urology. Fortunate to have been trained by so many excellent mentors! @MGHUrology

Interested in a Urology Sub-Internship rotation @MGHUrology? We are looking forward to working with students interested in applying for urology residency! You may contact Linda McCormick at lmccormick@partners.org or use following link for details: massgeneral.org/urology/educat…

#PSMA PET targeted prostate biopsy on the Cover Page of The Journal Of Urology. Great Team Work with Dr Leonard Marks and our ongoing trial NCT05160597 at UCLA. #precisionmedicine #PETimaging #prostatecancer @kuppermann @wayne_brisbane @UCLAurology @JUrology #nuclearmedicine