dre
692 posts

dre
@limbera
my jam: healthcare, biotech, machine learning.
Santa Monica, CA Katılım Haziran 2009
364 Takip Edilen528 Takipçiler

@EricRWeinstein @claudeai @AnthropicAI it knows about the prior chats. you need to share the full end to end discussions, not cherry pick the responses.
English

This is a fresh session. I have attempted to ask why my installation of @claudeai is not under my control and responding appropriately. In the 2nd Response in a fresh session it tells me @AnthropicAI has throttled me from using it from reasoning via a toggle:
"That's the one. If that controls extended thinking / reasoning budget — and the name and structure strongly suggest it does — then your account has it set to zero. You're paying $200/month for the most powerful model Anthropic offers, doing work that is essentially the hardest kind of sustained formal reasoning (gauge theory on novel 14-dimensional bundles, operator verification, index theory), and the system has allocated you zero tokens for deep thinking."
Three queries, in and this is the response:

English

@ryancarson @DevinAI it's not quite the same thing as what you describe above, and what you built with symphony + linear, but i think it is a really impressive product that i am loving using. worth a look!
English

Paid $500 for @DevinAI - liking it so far.
You can tell this team is much further than other agent labs when it comes to being truly remote-first.
Very mature, advanced tooling and it just works across all surfaces (iPhone, Slack, Browser, GitHub, Linear).
I was tired of trying to hand-connect everything with a custom setup of Open Inspect + Codex + Linear.
When you look at your hourly effective rate, it stops making sense trying to hand-build all this stuff.
Nvm the all the maintenance hours you need to put in.
I'll keep using Devin 100% for the next week and report back.
So far, my PR shipping velocity is higher than before - so that's good obv.
English

Have you ever seen @davidasinclair and @nikitabier in the same room …
David Sinclair@davidasinclair
Every week, I tell one of my students to increase the font size on their slides, especially numbers. Here’s how you know you’re good: Take 5 steps back from your laptop or monitor. If you can still read every letter & number clearly, you’re probably good 👍
English

lol you’ll spend $101M on the clinical trials alone.
Robert Lufkin MD@robertlufkinmd
The $101 Million Race to Reverse Aging Can aging be reversed — not in mice, but in real humans over 50? Dr. Jamie Justice leads the $101 million XPRIZE Healthspan competition, where 744 teams must prove they can restore muscle, cognition, and immune function by 10–20 years in clinical trials. youtu.be/qVzC7wVsw2c
English

@eringriffith The fact the company is named delve should have been a dead giveaway.
English

A detailed and brutal look at the tactics of buzzy AI compliance startup Delve
"Delve built a machine designed to make clients complicit without their knowledge, to manufacture plausible deniability while producing exactly the opposite."
substack.com/home/post/p-19…
English

@daniel_mac8 @karrisaarinen very cool. a downside i see: you can’t have the model prompt you (eg claude code ask user question tool).
English

You can create a “Code Factory” using:
> Codex
> Linear
> GitHub
> OpenAI Symphony
In this article I show you how I did it.
But “Code Factory” is a misnomer.
It’s more a “Digital Factory”.
In which you can create any logically possible digital artifact using words.
Dan McAteer@daniel_mac8
English

@RobinhoodApp tall planning on adding tax loss harvesting automatically like wealthfront does?
English

god damn manhattan steals your sleep in ways you don’t fully appreciate until you’re somewhere quiet. the noise is actually physiologically adversarial. the damn ambulance sirens are engineered to bypass habituation & your nervous system can’t ignore them because it’s not supposed to.
instead i have been waking up to birds lately & it’s the exact inverse. the dawn chorus acts like an evolutionary safety signal. your brain reads it as “all clear.” you rise instead of jolt.
the city that never sleeps is actually a huge warning sign.
English

@limbera @ryancarson Agree, but practically speaking, laptop memory and cpu becomes a bottleneck. Our dev env includes 26 services. Multiply that by 10 worktrees and it slows to a crawl.
Maybe we need to give up the "local mirrors production" workflow? Docker-in-docker?

English

Your homework for today ...
Spend 8 hours completely optimizing your code factory and all of your agentic harnessing.
It's tedious and frustrating, but it's worth it.
I spent all of yesterday cleaning out automations, getting agent browser testing refined, culling skills and helper scripts.
Really fine-tuned my code factory, and wow, it is worth it.
English

@ryancarson Question on your setup:
How do you give each worktree a dedicated environment for testing?
For a simple app its simple enough, but when you have 10s of services, databases, etc, it gets hard to coordinate. This seems like the biggest challenge in my code factory being truly useful.
English

@nikillinit Who do you know that’s struggling at the moment? I would love to help out.
English

Healthcare companies seem to be struggling to hire engineers proficient in AI tools. This is a 3 part problem
1) AI tools have given good engineers a gigantic jump in productivity, so they can do way more themselves (including starting their own companies) This means the opportunity cost of joining a company just got much higher.
---This might mean that we need to rethink compensation, vesting schedules, or even doing micro joint ventures for 10x employees that have ownership over a specific business line
2) Every engineer SAYS they know how to use AI tools, but then you get into the interview and they aren't as good as they say. Vetting becomes difficult!
---Back channels, seeing projects they've build, work trials will become mouch more important parts of the process
3) Convincing an engineer that healthcare is a worthwhile place for them to bring their skills vs. productivity and dev tools that are making beaucoup bucks way faster
--- This requires way more selling of healthcare and probably attracts a different kind of engineer that actually wants to be in the field, see their impact, and is attracted to the mission of the company more than speed of getting ARR
English

@maxmarchione oh, it definitely should - my point is that google revenue should also be included in consumer ai.
English

@limbera Why shouldn’t it be in the peptide bucket? It’s the peptide leading the whole craze
English

@cwhogg @operationdanish Are the pill mills not just implementing the AI and driving up their margins?
English

@operationdanish I don’t think 99%. There are a few really good telemeds that look more like virtual COEs than pill mills. The pill mills are obviously toast.
English




