Nicholas Tay

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Nicholas Tay

Nicholas Tay

@malayoman

Discovering new intersections of light & matter. Ruth L. Kirschstein postdoc @Muirlab formerly @RovisGroup & @NicewiczLab. 1st gen immigrant 🇲🇾(he/him) #YNWA

Princeton, NJ Katılım Mayıs 2009
891 Takip Edilen394 Takipçiler
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Nicholas Tay
Nicholas Tay@malayoman·
Excited to share that our protein editing method from the @MuirLab is now published in @ScienceMagazine We believe that protein transposition will enable new biochemical studies of PTMs and open up new intersections of proteins and small molecules science.org/doi/10.1126/sc…
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The Muir Lab
The Muir Lab@MuirLab·
Check out our latest efforts published in @ChemicalScience on characterizing and engineering the NrdJ-1 intein for protein biochemistry and chemical biology applications! Congrats to @XuanjiaYe, Josh, Christian, @thegoodnush and Juner! @PrincetonChem
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Swiss Ramble
Swiss Ramble@SwissRamble·
Liverpool's signing of Florian Wirz represents a total commitment of at least £200m, based on figures reported in the media. Annual PSR impact £40m #LFC ⚽️ Transfer fee £100m (€118m) ⚽️ Add-ons £16m (€19m) ⚽️ Weekly salary £355k ⚽️ Agent fees (assumed as 10%) £10m
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Grace Robertson 🏳️‍⚧️
Grace Robertson 🏳️‍⚧️@GraceOnFootball·
arne slot how did you do this. you broke him.
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Sean Rogers@Sean_Rogers

Review post Brighton is out on @TheAnfieldWrap with @Knox_Harrington @dan_morgan3 & me @Statsbomb data ⬇️ Note Darwin Nunez: 1) Pressures vs Brighton 2) Season wide data (100 highest - 1 lowest percentile rankings) -Selections & Approach -Liverpool shape & approach out of possession particularly in opposition build up phase Time to make some tweaks? If so where & how? -1st half issues -2nd half changes & approach -Gomez -Jones -Diaz -Tsimikas -Endo Plus loads more discussed & debated

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Northeast Corridor
Northeast Corridor@NJTRANSIT_NEC·
Princeton Shuttle (Dinky) service is suspended in both directions due to mechanical issues. Substitute bus service is being provided.
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Gihoon Lee
Gihoon Lee@GihoonLee1·
Excited to share our @nchembio publication! Our proximity-triggered protein trans-splicing technology enables precise, time-resolved activation of diverse proteins by manipulating control elements (1/5) nature.com/articles/s4158…
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The Muir Lab
The Muir Lab@MuirLab·
Check out our latest paper in @nchembio, where we developed our CAGE split intein platform to study signaling events using proteomic profiling. This enables insights into the differential molecular connections of fusion oncogenes. Congrats to @GihoonLee1! nature.com/articles/s4158…
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Nicholas Tay
Nicholas Tay@malayoman·
@TheTransferFlow How about available DMs that would improve Liverpool beyond what they would currently have?
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The Transfer Flow
The Transfer Flow@TheTransferFlow·
What should we write about next week?
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Nicholas Tay
Nicholas Tay@malayoman·
Congrats to Yi, who has labored hard on this problem, and the rest of the team (Xuanjia, @jeremyaowen, @Hengyuan_Liu03, @rtho5616 ) for their contributions! It will be exciting to see where this technology will go in the future.
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Nicholas Tay
Nicholas Tay@malayoman·
Late to highlight this, but excited to share the latest intein engineering work in the @MuirLab that I've been able to contribute towards. In short, we think that this protein transposition technology can help us to study the functional landscape of IDRs within folded proteins
The Muir Lab@MuirLab

Ever wanted to swap out an entire internal region of a folded protein for functional biochemical studies? Check out our preprint that has been 5 years in the making, in which we establish a protein editing platform via protein transposition, enabling the insertion of functional cargo or PTMs into internal folded protein regions. #proteinengineering #proteinediting biorxiv.org/content/10.110…

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Damon Runyon Cancer Research Foundation
Damon Runyon Cancer Research Foundation@DamonRunyon·
@jeremyaowen aims to expand our understanding of chromatin remodelers, complex protein machines responsible for packaging DNA and regulating gene expression.
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Grace Robertson 🏳️‍⚧️
Grace Robertson 🏳️‍⚧️@GraceOnFootball·
Really sorry the newsletter didn't come out this week, caught a nasty case of the flu, but working on the next one on Arsenal, and how they're doing very well right now.
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Mohamed
Mohamed@MoeSquare·
Still maintain Mbappe should take a gap year and sign for some random mid-level club in Europe to see how high up the table he can drag them with his presence
David Ornstein@David_Ornstein

🚨 BREAKING: Kylian Mbappe has communicated decision to leave PSG this summer. Terms yet to be fully agreed. #PSG + 25yo will communicate when finalised in coming months. Will save club €200m per year & they will focus on youth / collective @TheAthleticFC theathletic.com/5205902/2024/0…

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Keşfet

@ChemicalScience @XuanjiaYe @thegoodnush @PrincetonChem @SwissRamble @Zhi_Lindsey_Lin @MuirLab @ScienceMagazine