Merve Yigit

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Merve Yigit

Merve Yigit

@mervisyigit

PhD Student @uzh_irem. @SendoelLab dedicated to solve the alternative translation puzzle in cancer #eIF2A #cancer #stemcells #RNA #proteomics #crispr

Zurich, Switzerland Katılım Ekim 2018
367 Takip Edilen114 Takipçiler
Merve Yigit
Merve Yigit@mervisyigit·
I’m thrilled to share my very first first-author preprint and our lab’s latest work💫 Check out how we challenged eIF2A’s enigmatic role in translation and learn more about its novel role in RQC!⭐️ #RNA #ribosome #eIF2A #translation
Sendoel Lab@SendoelLab

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x biorxiv.org/content/10.110…

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Merve Yigit
Merve Yigit@mervisyigit·
@KoliaRoiuk I understand what it means! 🤜🏻🤛🏻 congrats!!
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Mykola Roiuk 🇺🇦
Mykola Roiuk 🇺🇦@KoliaRoiuk·
Once I've read at "lolmythesis.com": "I studied a protein for 4,5 years nobody ever studied before. Now I know why." Whoever wrote it, I am sure you studied eIF2A. We tried so hard but found no role of eIF2A in HeLa cells. Have a look at our recent preprint:
bioRxiv Molecular Biology@biorxiv_molbio

Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control biorxiv.org/cgi/content/sh… #biorxiv_molbio

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Merve Yigit
Merve Yigit@mervisyigit·
Preprint alert 🔔 check out the latest biorxiv from my lab featuring in vivo single cell ribosome profiling in aged mouse skin! Big congrats to amazing scientist behind this hardwork @clarasdure !
Sendoel Lab@SendoelLab

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse skin. 1/6 biorxiv.org/content/10.110…

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Sendoel Lab
Sendoel Lab@SendoelLab·
Final day of the Ellis and Sendoel lab retreat in epithelial biology. Excellent presentations, exciting new ideas, wrapping up with a visit to Pisa.
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Merve Yigit
Merve Yigit@mervisyigit·
It was an exciting moment to share my PhD project on eIF2A at the Cold Spring Harbor Translational Control meeting. I met great scientists from all over the world, exchanged ideas and enjoyed the great location! Thanks to all organizers! @cshlmeetings #cshltranscon @SendoelLab
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Merve Yigit
Merve Yigit@mervisyigit·
Check out @PeterFRenz3 incredible work published @Nature ! It has been a long journey and I’m so proud of him to finally have come to the end! Amazing science and amazing colleagues 🙌🏻
Sendoel Lab@SendoelLab

Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out @Nature, we identify distinct TNF programs during tumor evolution. 🧵 nature.com/articles/s4158…

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Sendoel Lab
Sendoel Lab@SendoelLab·
Huge congratulations to Ramona for being awarded the prestigious Ernst Hadorn transitional fellowship, marking a first (and important) step towards an independent position! ernsthadornfoundation.org/ernst-hadorn-f…
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Sendoel Lab
Sendoel Lab@SendoelLab·
The dark proteome encoded by more than 7200 annotated sORFs is redefining our understanding of the human genome. Interested in how to detect microproteins? Check out Fabiola's recent review "No country for old methods". sciencedirect.com/science/articl…
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Sendoel Lab
Sendoel Lab@SendoelLab·
Snowflakes and science at our traditional IREM retreat in the magical landscape of Sils Maria. Great discussions and a lot of fun with our invited guest from Vienna, @s__ellis.
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Merve Yigit
Merve Yigit@mervisyigit·
An honourable moment to present my poster at #EMBLprotein conference to William Merrick who started all by discovering #eIF2A nearly 50years ago, and we are still trying to find its function! Thanks to all for this meeting and exciting discussions #Sendoellab #EMBL @EMBLEvents
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Hsieh Lab
Hsieh Lab@HsiehLab·
It is a treat to be surprised by joy once. It is a blessing to be surprised by joy twice in about 2 weeks. Introducing DOCTOR Alexandre Germanos @Alexrnagerm @HsiehLab @fredhutch @MCBSeattle Looking forward to all the cool stuff you will discover as a postdoc!!!
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Merve Yigit
Merve Yigit@mervisyigit·
New paper alert 🚨 Check out our newest paper to learn about how cells alter protein synthesis rate by switching between 5′UTR isoforms! Congrats to @RamonaEWeber and whole Sendoel lab 👏🏻
Ramona Weber@RamonaEWeber

How do cells couple mRNA transcription and translation? By profiling different cell types of the skin we uncovered that the precise 5'UTR isoform alters the mRNA's translational efficiency by exposing or hiding 5'TOP sequences. nature.com/articles/s4138…

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