Merve Yigit
60 posts

Merve Yigit
@mervisyigit
PhD Student @uzh_irem. @SendoelLab dedicated to solve the alternative translation puzzle in cancer #eIF2A #cancer #stemcells #RNA #proteomics #crispr

The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x biorxiv.org/content/10.110…

Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control biorxiv.org/cgi/content/sh… #biorxiv_molbio

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse skin. 1/6 biorxiv.org/content/10.110…






Clonal expansions can remodel entire tissues even when they appear normal, but what mechanisms drive this? And how do these processes differ from tumorigenesis? Out @Nature, we identify distinct TNF programs during tumor evolution. 🧵 nature.com/articles/s4158…








Congratulations to Dr. @ElianaBianco_ from @PeterLab8 She did a tremendous job at defending her thesis work on Ribosome hibernation. We wish her all the success in her future endeavors. Keep an eye on her great story to be submitted soon. #PhDone #AcademicTwitter @ETH_en











How do cells couple mRNA transcription and translation? By profiling different cell types of the skin we uncovered that the precise 5'UTR isoform alters the mRNA's translational efficiency by exposing or hiding 5'TOP sequences. nature.com/articles/s4138…



