Nelson Royall, MD FACS

@GarciaOlmoD @VillarejoCampos @DrSGlezMoreno @h_guadalajara Adj HIPEC with Ox during 30 minutes did not improve the Recurrence Free Survival in COLOPEC trial, however adjuvant HIPEC with MMC improved the locoregional control rate at 3 y in HIPECT4 trial. jamanetwork.com/journals/jamas…

Happy to share our work from @metrohealthCLE (FREE download from @SurgJournal until December 23!) on #MALS. For MALS surgeons out there, are you routinely performing a ganglionectomy and lymphadenectomy? @jamiepdecicco @fnuraja @MalsNational authors.elsevier.com/a/1i1K690L%7Ex…

Today: #CAMINO trial #CRLM published in @TheLancetOncol; great team effort with @EAHPBA surgeons & radiologists from 14 centers 🇳🇱🇳🇴🇮🇹🇧🇪 ✅#MRI changes clinical management in 32% of 298 patients scheduled for #surgery / #ablation of #colorectal #livermetastases based on CT only. ✅Results confirmed by “blinded” expert panel. doi.org/10.1016/S1470-…

🔥of the press: Molecular profiling in cholangiocarcinoma: a practical guide to next-generation sequencing @OncologyAdvance Cancer Treatment Reviews doi.org/10.1016/j.ctrv… 👉GA are actionable in 30–50% of CCAs 👉we provide practical advice on NGS use & a detailed overview of frequently used NGS tests @myESMO @EASLnews @ILCAnews @curecc #livertwitter

Effect of HIPEC on Cytoreductive Surgery in Gastric Cancer With Synchronous Peritoneal Metastases: GASTRIPEC-I Phase III @JCO_ASCO doi.org/10.1200/JCO.22… ❓to do or not to do 👉HIPEC improves PFS, but not OS 👉Subgroup may benefit more, PCI ≥7 🧐Debate continues.. @myESMO

#ESMO23 MATTERHORN study: Perioperative durvalumab+FLOT in gastric/GEJ cancer Durvalumab vs Placebo pCR➡️19.0% vs 7.0%✅ R0 resection➡️similar (86%) Presented by. Dr. Salah-Eddin Al-Batran @myESMO @oncodaily @VJOncology @Oncoinfo_it @OncoAlert

Should pts w/ #idiopathic #pancreatitis undergo EUS? How often #surgery 🔪 required? #PICUS trial: 105 pts IAP, 24 centers 🇳🇱; EUS found a cause in 32%; biliary (24%) - #cholecystectomy, chronic pancreatitis (7%), and neoplasm (3%) - #pancreatoduodenectomy IAP recurrence in 1-year: 17% with negative EUS ❌ 6% with positive EUS ✅ ➡️academic.oup.com/bjs/advance-ar…

The first ever Radiomics 👾 preoperative fistula risk score !!! Development 🇳🇱 and external validation 🇮🇹 🐳 The radiomics-based preop FRS performed similarly to the existing scores ( ROC 0.8) 💪 Great added value considering only CT derived data! academic.oup.com/bjsopen/articl…

🔥off the press: Tislelizumab vs Sorafenib as 1st line Treatment for HCC @JAMAOnc doi.org/10.1001/jamaon… 👉ORR: 14.3% vs 5.4% 👉mOS: 15.9 vs 14.1mo 🧐non-inferiority, in line with Nivo & Durva, but we need a "niche" or a biomarker... @myESMO @EASLedu @ILCAnews #livertwitter

We know that the risk of small intestinal NETs (siNETs) is increased among 1st degree relatives - I am following a few families. This GWAS study identified 4 novel risk loci for small intestinal NETs including a missense mutation in LGR5. Very interesting sciencedirect.com/science/articl…

Outcomes of pancreatic cancer with liver oligometastasis - Takeda - 2023 - Journal of Hepato-Biliary-Pancreatic Sciences - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/jh…

Phase I/IIa Trial of Yttrium-90 Radioembolization in Combination with Durvalumab for HCC @CCR_AACR 10.1158/1078-0432.CCR-23-0581 🔎🇰🇷, 24pts 👉mOS n.r.; mPFS 6.9 mo 👉CR: 29.2%, PR: 54.2% 👉clinically feasible & encouraging efficacy @myESMO @EASLedu @ILCAnews #livertwitter

Important paper. Can ChatGTP give patients the wrong information. Study finds nearly a third of recs were not concordant with NCCN guidelines. Garbage in ➡️ garbage out. We saw this during Covid. ⁦@JAMAOnc⁩ ⁦@SWOG⁩ ⁦@DavendraSohal⁩ jamanetwork.com/journals/jamao…

The role of adjuvant chemotherapy (AC) in patients with ampullary adenocarcinoma (AA) remains controversial. This study aimed to determine if AC improve the prognosis of patients with resected AA. Read at: journals.lww.com/journalacs/ful…

Great overview of role of #surgery in #PancreasCancer with metastases. Limited data and need trials initiated to guide decisions ⁦@AHPBA⁩ ⁦@IHPBA⁩ sciencedirect.com/science/articl…

Fatty Liver= #SLD #NAFLD= #MASLD #NASH=#MASH #MASLD who drink ethanol > 140 g F or 210 g M weekly= #MetALD Alcohol related liver disease= #ALD SLD with known cause (drug, Wilson, other genetic etc…) = specific etiology SLD SLD without known metabolic or other risk= cryptogenic SLD

JUST OUT! Honored to serve as the senior author in @TheLancet re: Phase 3 FRESCO-2 #fruquintinib with improved OS and PFS. thelancet.com/journals/lance… Just a joy to work with @adasarimd @MDAndersonNews @hutchmed @TakedaOncology. @VUMCDiscoveries @VUMC_Cancer #crcsm #CancerResearch

CA19-9 Response to First-Line #Neoadjuvant #FOLFIRINOX and Second-Line #Gemcitabine / #NabPaclitaxel for Patients with Operable #PancreaticCancer @SamThaljiMD @isteaus @MCWSurgery @MedicalCollege rdcu.be/ddOte #VisualAbstract

@erin_schumer @WashU_CT @WashUSurgery @AmitPawaleMD @MFarazMasood @KunalKotkarMD @UofL_cts @UofLHealth @uofl Congrats!

Walking into my last day as a trainee! Thank you @WashU_CT @WashUSurgery @AmitPawaleMD @MFarazMasood @KunalKotkarMD for an incredible🫀failure year! Heading back to @UofL_cts @UofLHealth @uofl as assistant professor in adult cardiac surgery!

Drainage of large walled off pancreatic necroses 🥎 a RCT from 🇩🇰 EUS guided Plastic 🤜🤛 LAMS 🟰 technical success (95 / 100%); adverse events and length of stay 🤔 for large WON are LAMS not superior?! Want to hear comments from my endo friends! gut.bmj.com/content/72/6/1…