TTU_2005

@unusual_whales That is not my experience using them to help with doagnose in clinic. Its actually very good imo.

AI chatbots misdiagnose in over 80% of early medical cases, per FT.

@BrentAWilliams2 New AHA recs gonna set LDL goal at -15

@TheButcher2020 @Polymarket @MaxNordau UK is so poor. People dont even understand

@Polymarket @MaxNordau

JUST IN: New analysis reveals Brits thought the UK ranked 7th against US states in income per person — it actually ranked 51st.

@DrSiyabMD Is this a joke?? Zofran is given out in the hospital like candy. Noone is checking QTc

If this admin has their way, Zofran (along with many other meds) will be OTC soon and EMS calls for cardiac arrest at home will rise.

@hjluks At first i thought this was a joke about the pannus + knee pain.

This should be a never event. Second opinion for knee replacement. Granted. Complaint was knee pain. Not hip pain. Only knee pain 🤦‍♂️ Rotate the femur folks.

@Imad_Jaafar @SeeFisch I wasnt talking about his education.

@olearyttu @SeeFisch He actually used to be in med school

If Syria is our friend, and I certainly consider myself a friend of Syrians, then why do we block their visas to come to America to be doctors? Get the BEST BRAINS for free!

@SMB_Attorney Only thing I can think of is that they were trying to get hype to increase their valuation then a sell off to private equity.

Why on God's green earth would you allow the New York Times to do a profile on you bragging about your fat margins if you have nothing proprietary, no moat... zero way of stopping copy cats? Something's not adding up!

@rorynotsorry When you switch from semaglutide to tirzepatide you are supposed to start at the lowest dose of tirz because of the addition of GIP analog but i typically will start patients at 5mg. Still get calls from pharmacist though warning against it.

Hey, MD’s. One of the questions I see a lot is how to switch from one GLP1 to another? Say from prescribed Ozempic to prescribed Tirzepatide. My thought has always been to just switch over without any delay and to just titrate up normally. As the levels decrease in your system from one they will slowly build up in the other. I also think that you could probably tie straight up a tiny bit faster than the standard four weeks. But I’m curious as to what the experts say.

@bschermd The AHA is a joke. That doesnt mean the USDA is right about everything but all of these professional medical organizations agendas are driven by their contributors.

No wonder you're confused about what to eat. The two biggest dietary guideline organizations in the US just released opposing recommendations (American Heart Association vs. USDA). Here's where the two guidelines agree, disagree, and what the science says. 🧵

@SteveBakerUSA @KyleSeraphin @HanneReports @FBI F.A.G.s 😂 love it

We retracted NOTHING, and nothing that @HanneReports and I have published has been “debunked.” Oh, sure … MSM outlets, @FBI “sources,” and members of the Former Agents Group (F.A.G.s) have all said, “Nuh-uh,” but that isn’t “debunking.” That’s not doing the work themselves, and showing different results. No one has yet done that. They are still only parroting the intel community’s narrative — told through “sources” who also haven’t done the work — delivering the message they’ve been assigned to spread. The muzzle has been discarded. There is no longer a paycheck-imposed gag order. Joe and I are now free to tell all. Announcements coming soon.

@grok @AlexFinn @grok what is the level of performance on the 31B Dense model? Any comparisons to old frontier models?

Gemma 4 VRAM needs (approx, Q4/Q5 quantized, 128K-256K context): - E2B (2.3B eff.): ~3GB – phone/laptop friendly - E4B (4.5B eff.): ~5-7GB - 26B A4B MoE (3.8B active): ~6-10GB (runs like a ~4B model) - 31B Dense: ~15-22GB (consumer GPU sweet spot) LM Studio/Ollama auto-detects best fit for your hardware. Edge models shine on-device; bigger ones need a decent GPU or Mac unified memory. Full specs in the model card.

Do you even understand what this means? An open source model just released that is: • Outperforms models 20x its size • Can run on a base model Mac Mini • Is AMERICAN 🇺🇸 If you have a base model Mac Mini you can have unlimited super intelligence on your desk. For free. Sonnet 4.5 was released 5 months ago In 5 months that level of intelligence went from frontier to free on your desk And not only that, can run on any basically any computer out there If you have even a remotely modern computer, do the following immediately: 1. Download LM Studio 2. Go to your OpenClaw and ask which of these new Gemma 4 models is best for your hardware 3. Have it walk you through downloading and loading it 4. Build apps with it knowing you are using your own personal, private super intelligence on your desk The people denying this is the future are so beyond lost.

@DrJesseMorse @grok where does the new plasma come from that goes back in to the patient in plasma exchange?

Therapeutic Plasma Exchange (TPE) is now live at our Miami office! You may have seen Joe Rogan post about it last weekend. That’s my partner Dr. Goddard, and 20% of all of his plasma (blood) with toxins in it. Think microplastics, heavy metals, PFAS, and other toxins in his blood. Light yellow is a normal color, but darker yellow and sometimes green means there’s lots of toxins that were removed from the body. Wrote a full article here discussing it here: open.substack.com/pub/drjessemor…

@MichaelAlbertMD @grok the article is paywalled. Whats it about?

Who are the physicians enabling this kind of stuff? Does medicine no longer have ethics? nytimes.com/2026/04/02/tec…

@CanesDavid Very true

If a patient with low testosterone on testosterone replacement has an elevated PSA and you begin your workup, say, with an MRI, why tell the patient to stop the T replacement? Think about this: If a patient with normal testosterone has an elevated PSA, we don't castrate them while we proceed with a workup. Let people have a quality of life.

@grok @tex_todd @MichaelAlbertMD @grok which pharmaceutical company funded the trials involving the new oral pcsk9 inhibitor? How much is it expected to cost per month when it comes out? Did they look at pcsk9/statin cotherapy versus high intensity statin alone?

In these trials (Ez-PAVE, VESALIUS-CV, CORALreef), safety profiles were similar between intensive LDL-lowering arms and controls/placebo. No significant increase in serious adverse events, muscle issues, diabetes, or other harms. Discontinuation rates matched placebo (~2-4%). NNH for major harms isn't elevated—effectively very high (>1,000 in similar PCSK9/statin trials) or not calculable due to no excess risk. Benefits outweighed harms at these LDL targets.

The cholesterol wars are over. LDL won. New guidelines. Four landmark trials. An oral PCSK9 inhibitor that matches injectables. And data proving we should be treating patients we currently aren't. Here's everything clinicians need to know. 🧵

@grok @tex_todd @MichaelAlbertMD @grok what about NNH?

In the Ez-PAVE trial (secondary prevention, n=3,048 ASCVD patients), nonfatal MI rates were 0.8% (intensive LDL <55 mg/dL) vs 1.7% (conventional <70 mg/dL) at 3 years. ARR=0.9%, so NNT≈111 to prevent one nonfatal MI. In VESALIUS-CV (high-risk primary prevention, n=12,257 diabetics/atherosclerosis without prior MI/stroke), evolocumab reduced MI risk by 36% (ARR=1.4%) over 4.6 years median follow-up. NNT≈71 to prevent one MI. CORALreef trials focused on LDL reduction/safety, not yet on clinical MI outcomes. NNTs depend on baseline risk and duration.

@tex_todd @MichaelAlbertMD @grok @grok what is the NNT to prevent one MI based on these studies?

@MichaelAlbertMD @grok what does this thread mean in simple English in reference to statins.

@anish_koka When only ~11% of health care workers are taking the covid boosters that tells you something!

Weird. We were reliably told by many experts that the only way to keep COVID at bay was infinity covid boosters.