PAcMEN - ITN

This @thomasperli 👇 from @tudelft completed a #tourdeforce study on refactoring cofactor biosynthesis in @yeast with an absolutely excellent #phd defense. Excited to be part of your committee and @pacmen_itn journey. Congratulations to you + mentors @jgdaran1 & @Jack_Pronk_ !

Really cool #openaccess article from my colleague @aksnorw @pacmen_itn @IMB_TUDelft showcasing a great strategy to make yeast biotin prototroph, in the absence of oxygen! Check it out! #EU2020 authors.elsevier.com/c/1dF903vNLuD-…

One month to go to my #PhD defense and just placed an order for my #thesis books. Time is flying! Here is a @pacmen_itn themed #WordCloud of the main text. A good way to summarize the topic of my #research!

We have an opening for an ITN- ESR (itn-emuse.com) on model and data integration of microbial communities. See werkenbij.vu.nl/ad/e-muse-comp…. Please RT

Thrilled to share another chapter of my PhD book, just published on #MetabolicEngineering! We implemented Mo-cofactor synthesis in baker's #yeast, enabling nitrate assimilation. Check it out, it's #openaccess! #H2020 #MSCA #ITN @pacmen_itn sciencedirect.com/science/articl…

My latest paper with @Vassily_13 on dynamic models of gene expression and metabolism (dynamic ME-models) just got published! We explore how the diauxic growth of E. coli emerges from optimal growth under biological constraints! #h2020 pnas.org/content/118/8/…

Congrats to @realLCSB , @Vassily_13, @oftadehomid - and @psalvy_ from our programme!

Predictive engineering of cellar metabolism go.nature.com/3mUywve 🙏for the learning experience gained from this wonderful interdisciplinary & public-private effort, incl @mhgarci1 Jie Zhang, @soerpet @TeselaGen @jaykeasling @BenjaSanchez @ask_jens @DTUBiosustain @pacmen_itn

Check out this Elsevier article where our PI @MiKrogh talks about the biosensor research done by our ESRs @Vasil_dmb and Soren Petersen!

Wanna know what happens inside E.coli when it has too much to eat ? My preprint on the use of dynamic ME-models to study diauxie in E. coli is out! Big thanks to @Vassily_13 @pacmen_itn @DDDeCaF for the help along the way doi.org/10.1101/2020.0…

New pre-print out! Neo's are really cool fungi but they are hard to handle. We studied their adaptation to anaerobic environment by expressing key genes for NAD+ and CoA biosynthesis in yeast and found that this was enough to confer oxygen-independent co-factor prototrophy!

NICEdrug.ch is a resource for systematic and large-scale computational analysis of drug biochemistry, enzymatic targets, and toxicity inside cell @Vassily_13 @AnushChP @NoushinHadadi, Kiana haddadi, Jasmin Hafner,@realLCSB @pacmen_itn biorxiv.org/content/10.110…

Updated ATLAS of Biochemistry is a repository of ~150k possible biochemical reactions for synthetic biology & metabolic eng studies with new metabolites and improved enzyme prediction! @realLCSB @pacmen_itn @Vassily_13,Jasmin Hafner,Anastasia Sveshnikova dlvr.it/RWxbRP

New study published in @NatureComms today on increasing stress tolerance in yeast via evolutionary young genes - exciting output from #H2020 project CHASSY and a great collaboration between @UCCResearch, @chalmersuniv, @tudelft and @INRAE_France: go.nature.com/3aOweqh

And follow with Adaptive laboratory evolution and reverse engineering of single-vitamin prototrophies in S cerevisiae aem.asm.org/content/early/… Exploiting the diversity of Saccharomycotina yeasts to engineer biotin-independent growth of S cerevisiae aem.asm.org/content/early/… Enjoy!

It is end of April and you may need some vitamins. You can start by reading the collaborative hattrick by @aksnorw and @thomasperli, starting with Vitamin requirements and biosynthesis in Saccharomyces cerevisiae onlinelibrary.wiley.com/doi/10.1002/ye…

Want to join this happy group of synthetic biology researchers in London? 🧬⚙️🧫- We're now hiring for a new postdoc to join us once the labs reopen: see advert here - jobs.ac.uk/job/BZS744/res…

My latest article has been published on @AppEnvMicro! Check it out, it's #openaccess! @pacmen_itn #MSCA #H2020 Adaptive laboratory evolution and reverse engineering of single-vitamin prototrophies in Saccharomyces cerevisiae aem.asm.org/content/early/…

Really glad to see our review article featured on the @Yeast_Journal cover. Cool retro-gaming vibe with ref to the @pacmen_itn Need to make some space in my office!

The @Yeast_Journal issue featuring our vitamin review is out now and its cover image has a reference to @pacmen_itn Looking forward to download the Hi-res file to print and hang somewhere nice. onlinelibrary.wiley.com/toc/10970061/2…