James Richards

Freddie is looking down and giving y'all a standing ovation. That's spectacular!😍💗 The most INSANE Bohemian Rhapsody Flashmob you will ever see!! With 30 musicians and singers in the STREET of Paris 😍 Cre : Julien Cohen Pianist

Let this sink in…

Now THIS is a UK Government Petition I can really get behind ...

We scrapped all the youth clubs, made everything expensive, took away things like skate parks, built massive housing estates with no green space, and wonder why kids get up to no good online. It's a complete mystery that definitely isn't a problem of our own making.

Robbie Williams speech after winning the Best Film for Better Man at the AACTA awards… #AACTAs #AACTA #RobbieWilliams #BetterMan #BetterManMovie #AACTAAwards

NB @ElectoralCommUK

Brief cognitive-behavioral therapy (BCBT-inpatient), when added to standard care, significantly reduced suicide attempts and psychiatric readmissions in suicidal patients. ja.ma/4f56lUx

@SW_Help Just to say, thanks very much to the brilliant ticket inspector on the 13:30 from Dorchester South to Bournemouth. My original train was cancelled on another line. Really helpful advice, and printed off a new route. Great service, thank you.

Travelling with us tomorrow? Please check how we're running before you start your journey. More details ow.ly/zDkk2

Should we be rethinking tremor that does not respond to levodopa? Some folks quote 20-40% for this phenomenon? Swinnen and colleagues turn this notion on its head in their recent @MDCP_Journal paper were they argue with data it is actually ~4%. Key Points: - The authors comment that 'tremor in Parkinson's is commonly regarded as less responsive to levodopa.' - 526 folks. - All were screened for possible deep brain stimulation placement. - Improvement in tremor 86.8%. - Improvement in bradykinesia 45.7%. - Rigidity in 67.0%. - Full resolution most frequent for tremor 67.9%. - Levodopa-unresponsive tremor (improvement <25%) only in 4.0%. My take: Is it possible that we have been over-estimating the number of folks with levodopa unresponsive tremor? This paper would say YES. The tricky part, as the authors point out, is that tremor may also be a component of motor fluctuations. There are also cases where the tremor is partially responsive and if you catch it at the 'right moment' it appears to be completely responsive. This paper by Di Bie's group was very nice as it suggests that the proportion of patients w/ L-dopa-resistant tremor of 4.0% may be substantially lower than previously reported. So next time you see a case of possible medication refractory tremor think tabula rasa – a clean slate. Do not be biased by dogma, follow the data. …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md… #parkinson #deepbrainstimulation

Just a message to everyone out there, the NHS is underfunded, the French spend 30% more per person, the Germans nearly 50% more per person. The NHS is one of the most poorly funded Health Services in Europe. And it shows. #bbcqt

Remember, clocks go back tonight. If you're a Tory, back to 1953. If you're Reform, back to 1932. If you're Jacob Rees-Mogg, back to 1741. And if you're Nigel Farage, you just demand that 'Clocks Should Go Back Where They Came From."

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Check out our latest podcast episode, featuring @MichaelOkun! In this episode, he talks about the current technology and tools for making a Parkinson’s diagnosis, how they are used, and some of their limitations. 🎧 Our podcast is available on Spotify, Apple Podcasts, Google Play and TuneIn (Amazon Echo). You can also listen at Parkinson.org/Podcast. *Thank you to Biogen’s Luma study for sponsoring this episode.*

Richard Branson’s Virgin Medical company has received £2bn from NHS funding but hasn’t paid a single penny in tax. The scam of Privatisation that sucks all the money out of the system to Tax Havens.

Via @NatureMedicine: A new #DeepBrainStimulation cut in half the amount of time that people with #Parkinsons experienced their most bothersome symptoms: bit.ly/3NadPKg #NeuroTwitter @CarinaOehrn @scernera1 @NeurosurgUCSF @DrAlfonsoFasano @CBSwanMDPhD @MayoClinicNeuro

A person with Parkinson's disease can't walk because of severe freezing but put him on a bike and he is fine. Great case by Snijders and @basbloem Love the explanation: 'This striking kinesia paradoxica may be explained by the bicycle's rotating pedals, which may act as an external pacing cue. Alternatively, the motor-control mechanisms involved in gait as compared with other activities engaging the legs, such as cycling, could be affected differentially in Parkinson's disease. Cycling may offer a useful approach for exercise training in patients with Parkinson's who are “grounded” by severe freezing of gait.' nejm.org/doi/full/10.10… youtube.com/watch?v=aaY3gz…

@SoVeryBritish Spot on.

Every day.

Austerity is correlated with slower improvements in mortality in high-income countries. In case you missed it, this analysis from November 2022 provides evidence that the architects of austerity, no doubt, will ignore. sciencedirect.com/science/articl…