Leon

@bryan_johnson This is a fascinating finding! Thank you for your research 🫡

Two doses of magic mushrooms degraded my sperm count from the 99.6th percentile to the 77.7th. This may be a first-in-human observation. Context: we ran the most quantified magic mushroom (psilocybin) experiment ever conducted. We were asking if psilocybin is a longevity therapy. After seeing the data, we think it is (see reply post for the experiment summary). Also, like most things biology: the results are complicated. My data suggests that the magic mushrooms (psilocybin) negatively impacted my fertility markers. Before the first psilocybin dose my motile sperm count was at 99.6th percentile for men under 25 years of age, it dropped to 77.7% and partially recovered to 89.3% following the first dose, and second doses, compared to the same age cohort (numbers compare similarly to my age cohort as well). 3 days following my second dose (first dose 25 mg, second dose 28 mg) . Motility: dropped 51% . Total count: almost unchanged, dropped by 2% . Total motile count: dropped 52% . Normal morphology: dropped by 50% 20 days post 2nd dose, the pattern continued, with typical latent effects on total sperm counts Motility: recovered back to -2% of pre-psilocybin baseline: . Total count: dropped by 38%, latent effect. . Total motile count: remained inhibited at -39% of pre-psilocybin baseline, (despite motility normalizing, due to the total count drop) . Morphology normalized to -10% of baseline levels. Reduction in free testosterone might have contributed to the effect. While total serum testosterone increased by 30% 3 days following the 2nd dose (neither FSH or LH were meaningfully affected either), and continued to be at 11% above baseline, SHBG increased by 37%, SHBG binds testosterone and reduces its bioavailability and activity. My free testosterone (direct) showed 24% and 23% drops at 3 and 20 days post 2nd dose. In light of the neuroplastic, well-being, brain reset, and systemic metabolic and anti-inflammatory benefits, the trade-off is probably worth it. Especially considering that the magnitude of inhibition has no meaningful effect on actual fertility (total motile counts above 50 million are still on the safe side). This is a first-in-human observation, to our knowledge there is no published human clinical study demonstrating that psilocybin diminishes male fertility markers. General mechanistic evidence exists for recreational and psychoactive drugs possibly inhibiting fertility markers due to their effects on the hypothalamus-pituitary-adrenal axis and general hormonal reset.  Yet no direct evidence for psilocybin or other similar psychedelics inhibiting fertility markers exist. A potential mechanism for the immediate inhibition of motility could involve direct serotonergic signaling in sperm. Human sperm express multiple serotonin receptors, including 5-HT2A, and one recent study found that a 5-HT2A antagonist reduced sperm motility, suggesting that 5-HT2A may regulate motility. Psilocybin is known to bind 5-HT2A with high affinity.

Round 999 on Astra Malorum (Live Moment)

good morning everyone. doing the 5.24 grams of mushrooms yesterday was one of the best days of my life. it was healing, energizing and full of love. the coolest thing was doing this together, from the livestream crew and my team to so many of you, we had a deeply impactful shared experience. my phone has been blowing up. many tell me they called their parents, children and friends to express love and gratitude. that they have a renewed energy for health and life. life feels so fresh. i sincerely wish all the best for each of you. life is very hard and everyone is trying their best. we also make life so much harder on ourselves and each her than is necessary. i have hope that a new era of human existence is just around the corner and we might just be able to wrestle our most destructive instincts and amplify the splendor. i deeply appreciate my co-founder @_katetolo, she just makes everything better and more radiant. @RyanMField i’m very proud that we built the brain interface Kernel Flow. it was incredibly hard which makes the joy of using it to quantify my brain in this experiment a special kind of joy. Dr. Seger thanks for keeping me on task to get the biomarkers done lol thanks to my team for working so hard. thank you @ashleevance @naval @friedberg @Benioff @gjurvetson @HamiltonMorris for being good friends and holding space as I went inwards. @Grimezsz your set was magical. surreal. perfect. i really felt like i could see you and your artistic beauty. @AutismCapital you’re great. i don’t know who you are but you were first on the internet to start playing with me and i deeply appreciate and enjoy your presence. and thanks to my dad, son @talmagejohnson_ and @_katetolo for being by my side. that family time was the very best life has to offer. all my best to all of you 💙

@Treyarch @itsDkal @MrRoflWaffles Amazing recognition from Treyarch

First it was the highest round in the Beta, now the first to Round 999! Congrats, @itsDkal! 🤯

WORLDS FIRST 999 ON BLACK OPS 7 + FLAWLESS!

World’s First Round 600 on Black Ops 7 Zombies! @Treyarch @CallofDuty 999 is possible with just a few extra days. You challenged the community and i am taking it on. The time frame needs to be realistic. Is there anyway i could have more time? Tag treyarch in the comments 🙏🏾

I bought Chief Keef a Rarri & a Rover!

@stevewilldoit Great video. That’s so good for @ShaneStoffer man. Living crazy lives.

@dogubomb Hello, What’s the best way to get in contact with a member of the team? I’ve found an exploit and I would like to report it. Thank you.

👇Update on PlayStation Save Bug 👇 We’re still working around the clock with Sony to solve the PlayStation bug that has been affecting some save files. This issue will remain our top priority until it is resolved. (1/3🧵)

@CallofDuty #blackops6  Rahmoparmo#5092013 @CallofDuty

A vote for me earns Double XP! Reply below up to 3 times to earn 3 Double XP tokens available for Call of Duty: Black Ops 6 launch! Each reply (max 3) will earn 1 Hour of Double XP for Player, Weapon, and BattlePass at launch. 💥 #BlackOps6 🎮 Activision ID 🔥 @CallofDuty

@CallofDuty #blackops6  Rahmoparmo#5092013 @CallofDuty

@CallofDuty #blackops6  Rahmoparmo#5092013 @CallofDuty

We have a big announcement next week, so prepare for something... hauntingly familiar 👀

@wecreatestuff Whatever it is. I want it.

Make his finest asset yours Follow & Repost with #XboxCheekyControllerSweepstakes for a chance to win a custom Xbox Series X console & 2 Cheeky Controllers designed by Deadpool.‌ Ages 18+. Ends 8/11/24. Rules: xbx.lv/4cxoA4B @Marvel Studios' Deadpool and Wolverine, in theaters July 26

@Destiny2Team Hello, I have a suggestion. The new LFG is good, there is one thing that I would change. I think there should be a browse section on the main lfg page, you should be able to scroll through and look at most recent posts. For example if you want to jump into a random game mode.

Momentum Control will return to the rotator on January 30.

@RockstarGames That’s not the Red Dead 3 trailer…

Our trailer has leaked so please watch the real thing on YouTube: youtube.com/watch?v=QdBZY2…

We are very excited to let you know that in early December, we will release the first trailer for the next Grand Theft Auto. We look forward to many more years of sharing these experiences with all of you. Thank you, Sam Houser

Next month marks the 25th anniversary of Rockstar Games. Thanks to the incredible support of our players worldwide, we have had the opportunity to create games we are truly passionate about.

@ColeTaylor04 @shrmurda @gruuvies @Harlmason I’m your dad

@rahmoparmo @shrmurda @gruuvies @Harlmason Who are you and why have you tagged me again?

𝐅𝐑𝐄𝐄 mint Whitelist Giveaway 🔥🔥🔥 Giving out 3x Free mint Spots for @gruuvies Follow @gruuvies & @shrmurda Like ❤️ and Retweet 🔄 and tag 2 friends Ends in 24hours ⏰ Twitter picker ✅ Good Luck 🤞 #SolanaNFTs #WhitelistGiveaway #solana #SOL