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Sorry for the AI drop but this needs repeated everywhere. It was never just LDL. In 2025, research regarding the geometry of arteries and endothelial damage focuses on the dynamic, patient-specific relationship between complex arterial shapes—such as bifurcations, curvatures, and stenotic regions—and the resulting mechanical forces that cause endothelial dysfunction. Key findings emphasize that low or oscillating wall shear stress (WSS), driven by complex geometry, triggers endothelial dysfunction, leading to atherosclerosis and thrombosis. Key 2025 Research Areas: Geometry & Endothelial Damage Bifurcations and Curvatures: The 3D geometry of vessel branching points (e.g., carotid artery bifurcation) is a primary driver of turbulent, low-WSS (< 1 Pa) flow, which promotes endothelial injury, inflammation, and plaque formation. Dynamic Deformation: New models are moving beyond static, predefined geometries to account for real-time changes in wall tension during the cardiac cycle, showing that rapid, high-amplitude deformations in narrowed arteries cause severe damage to the endothelial monolayer. Stent Cell Geometry: Advanced research indicates that the specific design (cell shape and size) of coronary stents significantly influences the speed and success of re-endothelialization, directly impacting the risk of in-stent restenosis (ISR). Advanced Modeling (3D Printing & CFD): Studies are utilizing 3D-printed, patient-specific microfluidic models of, for example, pulmonary artery stenosis (30–80% narrowing) to map exactly how stenosis severity affects flow dynamics and causes endothelial cells to lose alignment and junctional integrity. Combined Mechanical Stressors: Endothelial damage is increasingly understood as a combination of fluid shear stress and cyclic strain, with research showing that equibiaxial stretching causes higher damage compared to simpler, uniaxial, or strip-biaxial stretching. Pathophysiological Impact Inflammatory Signaling: Disturbed flow caused by complex geometry activates the NF-κB inflammatory signaling pathway in endothelial cells, increasing permeability and creating a pro-thrombotic state. Vascular Aging: Progressive endothelial dysfunction and arterial stiffening (loss of elasticity) create a vicious cycle, where structural changes in artery shape worsen the mechanical environment, further injuring the endothelium. Stenosis and Turbulence: In regions with 60–80% stenosis, post-stenotic dilation leads to high-shear, turbulent flow, causing endothelial cells to adopt a pro-inflammatory, pro-thrombotic, and pro-angiogenic gene expression profile. 2025 Diagnostic and Clinical Trends Patient-Specific Modeling: The use of Computational Fluid Dynamics (CFD) on patient-specific, imaging-based (CT/MRI) models allows for calculating personalized risk by measuring local hemodynamic parameters, such as the Oscillatory Shear Index (OSI) and Relative Residence Time (RRT), to predict plaque progression. Carotid Stenting: Clinical trials, such as the Performance 2 trial, continue to evaluate the safety and efficacy of specialized stents designed to mitigate risks in complex, highly stenotic, and geometrically challenging carotid arteries.

@BenBikmanPhD We all know the opposite is true. You increase dose and then once you lose all of the weight then you lower the dose. Nobody needs to use responsibly it just works. It's not frigging rocket science here.

GLP-1 medications are powerful and need to be used responsibly. I strongly believe they should be used at a lower dose and cycled with the purpose of learning to control carbohydrate cravings. Remember, like with every drug, there's a diminishing returns, when the drug becomes increasingly less effective if a high dose is maintained. Have an "off ramp", where a person can see test whether they've learned new habits and overcome the cravings for carbs.

@AntiDoc Yeah, 100mg did make me breathe poorly until I found some supplements that counteract it. But still it is definitely rough vs 50mg.

100mg of anadrol is already pretty uncomfortable for me. It looks and feels like I gained 15lbs within hours. Kinda awesome, strong as fuck, look huge, but also hard to breathe during cardio and you can literally feel the water on your face. Anyway, point is, a lot of people see big dosages like this and think “man he must feel like an animal” But often times high doses of PEDs feel pretty terrible. For me, the sweet spot in terms of how I feel, is ~7-800mg per week if I had to guess. Curious to hear where you guys feel the best

@AdamBarretFSU @SBakerMD The only thing missing from his pic is a 3ml syringe sticking out his shoulder.

@AdamBarretFSU @SBakerMD Seriously these people bro lol

Why I DON’T take TRT despite being nearly 60 1. I’ve got zero clinical indications to do so (I’m not fat, I’m not weak, I have good energy, sexual function and libido are fine) 2. I have a very good lifestyle, I eat well, sleep well, don’t drink, train intelligently and recover intelligently 3. As a masters athlete, I want to compete in sports like track and field, weightlifting, rowing etc.. for which TRT is banned and I’m not a scumbag who would cheat 4. Personally, I don’t care what someone else does, but for me, I’d rather do it without drugs

@LynnieMitche @ShiningScience It just pains me why these companies even add extras. Like you have the fucking product already. Why add alcohols or maltodextrin or even preservatives? Also I found out it is EXTREMELY hard to get a factory to not add things you don't request.

@ree1dist @ShiningScience Organic Stevia seems to be safe... my go-to!

🚨 The widely used sugar alternative erythritol could be sabotaging your health. A new study shows it erodes the blood-brain barrier and inhibits the body's natural ability to dissolve blood clots. A new study from the University of Colorado suggests that erythritol, a sugar alcohol common in keto-friendly and sugar-free snacks, may directly damage the blood-brain barrier. By exposing cells to levels typically found after consuming a single sweetened beverage, researchers observed a spike in oxidative stress and the death of critical cells responsible for guarding the brain against toxins. This disruption shifts the body’s delicate chemical balance by reducing nitric oxide and increasing endothelin-1, causing blood vessels to constrict dangerously and potentially starving the brain of essential oxygen and nutrients. Beyond physical vessel damage, the sweetener appears to sabotage the body’s innate defense against strokes by blocking the release of tissue plasminogen activator—a natural "clot-buster" that dissolves blockages before they can trigger a medical emergency. These laboratory findings align with large-scale human observational data showing that individuals with high erythritol levels are twice as likely to experience major cardiac events. While regulatory agencies currently deem the sweetener safe, these results prompt a serious re-evaluation of the long-term health trade-offs associated with popular sugar substitutes. Source: Chichger, H. (2026). Common Sweetener May Damage Critical Brain Barrier, Risking Stroke. The Conversation.

@Yutaka_Culinary @TheShreddington I get one from Japan. I honestly can't recommend any since I haven't sent them in for testing personally. a.co/d/01pe8cOI That is the one I get. It has some red yeast rice but only 300mg. It has 2k natto also.

@ree1dist @TheShreddington Which brand do you like the most? I've only seen it readily available with Dr. Mercola but I can't find any third-party testing for them.

A few people have been asking me about the brand of NK I’ve been using these last two years that has delivered to me no measurable benefit at 16,000fu daily. It’s a well respected brand. NK is not a miracle supplement and should not replace any prescription provided to you by a doctor. If NK was of any profound benefit, it would not be so readily available (opinion).

@SaltyTroonTears @tbpn @MartinShkreli @AntiDoc @BowTiedYukon Paid lol

@tbpn @MartinShkreli @AntiDoc @BowTiedYukon @ree1dist Check this retard out. lmao

.@MartinShkreli says taking retatrutide is the "worst risk-reward decision you could possibly make": "The people that are taking peptides, and have these 'peptide stacks,' are mostly people in SF, maybe in NY. They're very wealthy people. They don't know what the rest of the world looks like." "Nobody else in Middle America is excited to do this. It's not normal to inject yourself with things. This isn't a thing everyone should be doing." "What is your upside to taking illegally manufactured retatrutide — you can't verify it, etc. — versus just taking Ozempic?"

You can stack them and maybe use a little less natto that way. I use 6k natto and 100mg lumbro. I started a new stack of supplements with it and in 2 days my health did a 180. I was in the er and feeling like crap and also I had problems with staying awake and going to gym. I am also doing french maritime and another type of pine bark, liposomal coq10 with pqq, and two stomach herb supplements. I am not sure what is working but I don't even have diarrhea anymore with 5 protein shakes a day. I also add lemon juice and lime juice to my morning electrolyte drinks. I did all this at once so I am not sure if it is any of them helping or all of them together lol.

@ree1dist @TheShreddington Oh wow, never heard of this. TIL.

@TheShreddington @dixietrigger It also doesn't work exactly same as natto. It doesn't thin blood it just targets the actual clots after they form. So it's safer than natto.

@dixietrigger @ree1dist It’s made of worms. Very strong.

@bowtiedmeathead Yeah true. I want to make it in the USA from scratch and sell it to people but then federal offense pl bullshit stops us. The quality could be good and price as well. Even if it cost 2 dollars a gram to make here.

@ree1dist That’s great. Very few ppl will do that though.

The attrition rates of TRT is quite eye opening… Some data shows 80–85% of guys are off TRT within a year in certain real-world studies. 8 out of 10 people stop treatment within a year. Read that again! That’s not a small number. That’s most people which is insane, right? Here’s the thing and the stone cold truth: Everyone thinks TRT is gonna change their life… More energy. More drive. Better body. Fix everything. But here’s the part nobody talks about… If your sleep sucks, diet’s a mess, you don’t train hard, and your life’s out of order… Sorry to burst your bubble but TRT isn’t saving you. It might help. But it’s not building a life for you… It’s not completely changing your physique like you envisioned “being on test” would do. Some guys don’t like the commitment. Some don’t like how they feel. Some just realize it’s not worth it. But most? They were looking for a shortcut. They thought TRT would literally turn their body into that of a Greek God. Yes TRT does work (very effectively in fact) Just not the way people think it does. It’s not the magic wand people think it is and it’s certainly not gonna change your life unless you have the lifestyle, dedication and commitment to back it up. Now on the other hand, if you are doing everything you can to maximize your fitness and health…getting good sleep, managing your stress your levels and decide to go on TRT bc your body is not producing enough testosterone on its own…then TRT will be a absolute Godsend for you However, if you are not putting in the work and doing your part then the chances of stopping TRT within the first year treatment is VERY HIGH.

@bowtiedmeathead I buy raws and make it myself. No underdose. Raws were 70 cents a gram for test 4 years ago.

Most of it is under dosed. I know this because a few guys I know were buy it from reputable UGL’s online only to get their blood work (which very few do) and their t-levels were much lower than expected. They then get pharma grade for not much more and can take a lot less to get their levels within same range.

@Liamjsm Id trust the price and condition from a used car seller for my teeth over a dentist.

Bizarre that dentistry isn’t a field of medicine. Dental research, what little there is, doesn’t meet medical standards. There are no incentives for dentists to focus on prevention, no coordination with doctors, no real standards for care. It’s absurd

@tiab33483 @hubermanlab Wait till you find out it's the same factories sending these pharmacies the raw api sources lol.

@hubermanlab Finally 👏👏👏 I’m tired of trying to explain biological roulette to patients and why peptides that come from a sterile, inspected pharmacies are the way to go despite being more expensive,

“Not for human use for research purposes only”= GRAY market. People doing non human research at home? In vitro? Nah. 0n animals? = illegal (animal welfare act). Crackdown on gray & black markets is starting now. Compounding pharmacies are here to stay. Expect more by the week.

@hubermanlab I wish we could ship all of the controlling people who ban shit to an island and let them just live off their lives screaming at clouds in the sky. I seriously wish it. I hate them with a passion.

It's better to get people on something that works immediately to fix some problems than nothing at all. I'll die by that statement. Doctors will wait until after death to give you some silly supplement that will fix some of your problems because of oh no it might do something XYZ bad. I will agree REGULAR TRT is a joke and stupid also but it's better than no TRT even if endogenous random crap shuts down. It is still better. I suffered through 2 years of hell getting on TRT because I was obese. I sweat yellow and had edema. I still credit for changing my life because it got me in a gym and on a 9 year journey to fitness.

@ree1dist All good, I expected this post to trigger people. I’m not worried though, I know your perspective on endocrinology will shift once I start dropping those articles

If you’re not a pro bodybuilder, jumping on TRT is honestly stupid, even if you stack it with HCG, SERMs, AIs, whatever. You’re still overriding your system and altering your brain, your pheromones, and way more than people realize. Good HRT should support and stimulate your own production, keeping all hormones and neurosteroids in balance, in the right ratios. Most people aren’t ready for that conversation yet… but I’m working on it.

@BigDadEnergyX Im the retard anon account that tells every woman to get on tesa hehe. It works amazing for them.

Because people are lazy and want a pill or liquid to do the work for them and or some retard anon account (not me) told them to.