Great @YaleMBB Undergraduate Research Fest today! Very impressed with today's student presentations. Congrats to our Undergraduate Sigler Award winners Kyle, Alexandra and Dami!
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Christian Schlieker
370 posts
Christian Schlieker
@Schliekerlab
Professor of Molecular Biophysics and Biochemistry and of Cell Biology @Yale @YaleMBB @YaleCellBio studying nuclear envelope dynamics and disease.
Connecticut, USA Katılım Mart 2020
301 Takip Edilen842 Takipçiler
Christian Schlieker retweetledi
For 50 years, DMRF has funded the discoveries that move dystonia research forward. The next breakthrough could be within reach—but only with your help. Donate and make a difference.
bit.ly/3ZCDtws
#dystonia #dmrf #dystoniafoundation
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Christian Schlieker retweetledi
In the Spring issue of the Dystonia Dialogue: Find out why the DMRF funds basic research and how studying drug targets led to more effective dystonia treatments (Part 2 of a 4-part series on DMRF research support).
bit.ly/4rDiINF
#dystonia #dmrf #dystoniafoundation
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Thrilled to be featured in the latest issue of Dystonia Dialogue! Our lab has been dissecting the genetic networks underlying dystonia, a severe movement disorder. Check out the article for a look at where our work is heading.
Dystonia Medical Research Foundation@dmrf
The Spring issue of Dystonia Dialogue is now live on the DMRF website! Learn more about the DMRF’s plans to recognize our 50th anniversary, rare genetic forms of dystonia, and how support groups keep people connected. bit.ly/4ssAViq #dystonia #dmrf #dystoniafoundation
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Christian Schlieker retweetledi
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains: Molecular Cell cell.com/molecular-cell…
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This was indeed a fantastic trip, thanks so much for hosting me! I very much enjoyed learning about fantastic science from you and your amazing @SumaraLab team and the great @IGBMC community!
Izabela Sumara@SumaraLab
Had the great pleasure of hosting Christian Schlieker @Schliekerlab for a seminar at IGBMC @igbmc. Thank you 🙏, Christian, for sharing your inspiring science and ideas, and for the engaging discussions with PIs and my team. A truly wonderful time! 🤩😄
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O'zapft is! great @YaleMBB Octoberfest yesterday with perfect weather and amazing home-brew!
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Christian Schlieker retweetledi
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences”
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
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Happy to see this excellent @laemmerdingLab discussion on our @schliekerlab and Mike's @hennelab recent work connecting organelles to intracellular forces!
Journal of Cell Biology@JCellBiol
.@JulieHeffler and @LammerdingLab @CornellBME discuss recent studies from the @Schliekerlab (hubs.la/Q03D99x00) and @hennelab (hubs.la/Q03D99zV0) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. hubs.la/Q03D97M70
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we suggest that multiple, weak ER spacer interactions create a system that is sufficiently dynamic to allow for secretion and passage of bulky cargo, yet avidity effects support organelle integrity and force buffering
Christian Schlieker@Schliekerlab
check out our new paper measuring intracellular forces: Nodal modulator (NOMO) is a force-bearing transmembrane protein contributing to a dynamic network of organelle-shaping proteins rupress.org/jcb/article/22…
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check out our new paper measuring intracellular forces: Nodal modulator (NOMO) is a force-bearing transmembrane protein contributing to a dynamic network of organelle-shaping proteins rupress.org/jcb/article/22…
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Congrats!!
Simone Reber@SimoneReber
✨Thanks to amazing students @TobiasKletter @MrEnkapsis, postdocs @bis_was_here & collaborators @Omar136661 @VasilyZaburdaev ALMF @EMBLHeidelberg ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉out today @NatureCellBio rdcu.be/eqPr8
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Christian Schlieker retweetledi
New study showing the development of pan-Expansion Microscopy by Morgan, King et al. @YaleMed to reveal the molecular composition and structural plasticity of individual nuclear pore complexes including LINC complex-dependent dilation. hubs.ly/Q03rSGym0
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a genome-wide CRISPR screen revealed strong ties between microcephaly-related genes and aberrant condensates revealing unexpected cellular pathology! Our chemical-genetic platform could accelerate the hunt for treatments for neurodegenerative and neurodevelopmental disorders
Christian Schlieker@Schliekerlab
🔬 Key findings: -RNF26 and ZNF335 protect against harmful protein buildup. -identification of compounds that have potential to counteract toxic condensates. -Links to zinc biology, autophagy, and oxidative stress offer new therapeutic angles.
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🔬 Key findings:
-RNF26 and ZNF335 protect against harmful protein buildup.
-identification of compounds that have potential to counteract toxic condensates.
-Links to zinc biology, autophagy, and oxidative stress offer new therapeutic angles.
Christian Schlieker@Schliekerlab
We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: biorxiv.org/cgi/content/sh…
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We’ve pioneered a disease-agnostic screening platform for aberrant biomolecular condensates—cellular structures linked to incurable neurological diseases. We screened genes and FDA-approved drugs that modulate disease-relevant nuclear condensates: biorxiv.org/cgi/content/sh…
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