simon clark

5.6K posts

simon clark

simon clark

@simoncclark456

hello

Katılım Ocak 2013
720 Takip Edilen128 Takipçiler
simon clark
simon clark@simoncclark456·
@des_ward @turnbjames @implausibleblog Why wait? You get financial savings from day one, especially if you get a battery at the same time, which you can charge in the cheap overnight window. Or if you use the Agile or Cozy tariffs.
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Des Thomas
Des Thomas@des_ward·
@turnbjames @implausibleblog Heat pumps are 4 x efficient than gas boilers. Even if using gas generated electricity it will therefore exceed the save half as much energy surely? For clarity, I have an EV but not a heat pump, as am waiting for the combi to go past its useful life
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Farrukh
Farrukh@implausibleblog·
Gent in yellow, "I'm an engineer, a scientist by background, and what I really care about is energy" "And that's one of these things which I feel has been turned into a culture war" "So let me say one thing" "We know that heat pumps, insulation, EVs, etc can save half your energy usage" "It's a massive difference" "And Iran, while, and this is not just about climate change, we can use as a strategic reserve" "We can use that oil for aviation or AI data centres" "But we've got politicians here on the table today, I believe, who deny these facts" "And why should we platform you when we can save that money? The energy. The money" "And this also means that we're not paying the oil money to Russia, which uses it to strike Ukraine every day, and we pay again for defence missiles" "So it's a very serious question. And this is the science, this is the fact. You cannot say that that does not save half the energy."
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simon clark
simon clark@simoncclark456·
@augustbythepond @cachavaa Farming animals uses vast areas of land. If we went vegan we would need less arable land as well no pasture, because we wouldn't be feeding billions of pigs, chickens and cattle in feedlots. Organic ag uses way more land than conventional ag. Where does the extra land come from?
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August | Mortenax saving 🗡️🥀🔥
@cachavaa And over processed“vegan” options are terrible for the planet. We need sustainable farming practices not plastic “vegan leather” and chemically engineered “vegan foods”. We are by nature born to eat meat and organic food products.
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simon clark
simon clark@simoncclark456·
@heavymetalcomic @cachavaa If you are anti capitalism then you should be vegan. The meat industry is massive, hugely more exploitative and environmentally damaging than big bean. If you want to keep eating meat, then you are pro capitalism.
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Goran Joksimovic
Goran Joksimovic@heavymetalcomic·
@cachavaa This! That is my problem with vrganisn. It stops just short of criticizing capitalism. I honestly feel like it's got to be some kind of pay op to keep white liberals focused on the wrong target. They have many valid grievances, but none of those problems will be solved by a diet.
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Simon Evans
Simon Evans@DrSimEvans·
THREAD: A heat-pump tumble dryer could save households more than £700 Lots of overblown reaction to govt phasing out standard dryers – reminds me of when 2009 Mail frontpage wailed about "beloved" incandescent bulbs But heat pump dryers are just a much better technology 1/5
Simon Evans tweet media
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simon clark
simon clark@simoncclark456·
@MasScavenger @karma44921039 I hate 15 minute cities. The very idea that I might be able to walk or cycle to access all the amenities I need. How dare they. I would much rather sit in traffic, as I go to the souless car park of a dreary out of town shopping centre.
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King Charlie
King Charlie@MasScavenger·
@karma44921039 Oxford is where the protests should be held, not London. It would be much easier to shut down Oxford and some might say, more relevant considering the plans Shut down the pilot 15 minute city
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karma
karma@karma44921039·
They’re going to divide Oxford into six 15mins neighbourhoods and you are only allowed 100 days of free travel per year through these six traffic filters during operating hours. This is the blueprint for a national rollout.
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Charles Steiner
Charles Steiner@NickCrum111·
@karma44921039 What legal idea is behind the idea of needing "permission" to do anything? I want to see the law.
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Wren Hamilton
Wren Hamilton@WrenHamilt61477·
@karma44921039 @HealthyEcon Allowed free travel? Why? They better come up with a bloody good reason. Id be looking for holes in the fence folks so they will then electrify it. Do not comply!
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Christopher
Christopher@CJ8350·
@karma44921039 It will be "Policed" by brain-dead muppets, who are willing to enforce this harm on their neighbours at the behest of the evil Cabal, to whom restrictions do not apply. If EVERYONE in Oxford simply REFUSED to be "Kettled", the scheme would fail. The "Covidians" will comply!!!!
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Bill
Bill@StillBill2026·
@karma44921039 I will NEVER allow some freaks who have lost their humanity to tell me where I can go and when. This is my country and I am a human being who lives my freedom and I will never accept slavery and subjugation, ever.
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millett445 🇬🇧
millett445 🇬🇧@millett4451·
@karma44921039 As Oxford is a university city, how will this work? A student of Oxford uni will not be able to attend school if they live in one area and the uni is in another. What about delivery people Off the emergency services? How will they cope? This is tyrannical overkill.
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simon clark
simon clark@simoncclark456·
@bleating_lamb The amount of processed meat on that kids plate means he will need some statins one day.
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Paul Davey 🚜🌾🐑🚛🏴󠁧󠁢󠁥󠁮󠁧󠁿🏉
Let food be your medicine…
Sama Hoole@SamaHoole

The British Vitamin D problem is not new. Britain sits between 50 and 58 degrees north. London is on the same latitude as Calgary. Edinburgh is level with Moscow. From October to March, the sun does not rise high enough above the horizon for the UVB wavelength your skin needs to actually reach the ground. You can stand naked in February noon sunlight on the south coast and produce essentially zero vitamin D. This is six months of the year, every year, for the entire history of human habitation on these islands. The British have known this, in their bones, for ten thousand years. Look at what was eaten in winter, before anyone had ever heard the term cholecalciferol: Oily fish. Herring, mackerel, sprats, kippers. Three or four times a week from October to March. A single kipper carries roughly 250 IU of D3. Cod liver oil. Spooned into every British child between 1850 and 1980, a teaspoon at a time. Distributed free by the Ministry of Food in the war on the explicit understanding that British children needed it through the dark months. Rickets fell by 90 per cent between 1940 and 1960. Cod liver oil was the reason. Liver. Eaten weekly in working households until 1985. Egg yolks from hens that had been outside in the summer. Grass-fed butter, made from cream from cows on summer pasture, the fat-soluble vitamins banked into the cream and eaten through the winter. The British solution to the British problem, evolved over centuries by people who could not articulate the biochemistry but knew, with absolute certainty, what kept the children growing through the dark months. Then between 1955 and 2010, the British removed almost all of them. Cod liver oil reduced to a niche supplement. Liver dropped from weekly to never. Oily fish consumption halved. Eggs rationed by the Department of Health on cholesterol grounds since retracted. Butter replaced with margarine carrying no fat-soluble vitamins at all. Result, by 2020: roughly half of all British adults are vitamin D deficient by the end of winter. A third of children. Rickets has reappeared in British paediatric wards. The NHS now recommends every adult take a supplement from October to March. This is the NHS recommending in 2026 what the British diet was doing automatically in 1926. The geography has not changed. The latitude is the same. The sun is still inadequate from October. The food used to handle it. The kippers are still being smoked at Craster. The cod liver oil is on the chemist's shelf. The liver is at the butcher. The butter is in the dairy aisle, behind the spreads. The sun was always seasonal. The food was the backup. The backup got thrown out. Get it back.

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simon clark
simon clark@simoncclark456·
@arhamgrowthcap @agingroy @Merck Ok. Why in people with lifetime low aboB levels (because of their genetics) is there a much lower plaque burden and far less heat disease. And why is the opposite true for people with genetics that cause an increase in lifetime apoB?
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Avi Roy
Avi Roy@agingroy·
A 65% cholesterol reduction has been available since 2015. Almost nobody could get it. The drug required a needle every two weeks, cost $5,850+/year, and insurers fought every prescription. @Merck spent a decade figuring out how to put the same mechanism in a pill. Enlicitide: 65% cholesterol reduction, 78% at target vs 20% for the best oral combo. Phase 3 (NCT06450366), published in @JACCJournals. Bonus nobody expected: it also lowers a genetic heart risk factor that affects 1 in 5 people. No other pill touches it. The biology was solved in 2015. The chemistry took until now.
Samuel Hume@DrSamuelBHume

These are really really nice data that've gone largely under the radar In people already taking a statin, Enlicitide (an oral PCSK9 inhibitor) was tested head-to-head against other cholesterol medicines — Bempedoic Acid, Ezetimibe, or the combination Enlicitide lowered LDL more than even the combination (and was the only agent to lower lipoprotein(a) too, by ~25%)

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simon clark
simon clark@simoncclark456·
@arhamgrowthcap @agingroy @Merck Arteries are a high pressure system. Branching points and bends are where collision against the artery wall happens, under pressure. The fewer apoB particles in the blood, the fewer can end up in the artery walls.
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Arham
Arham@arhamgrowthcap·
@simoncclark456 @agingroy @Merck apoB is not causal. If it were causal, the same blood flows through the veins. Veins never develop atherosclerosis (unless u surgically graft one into an artery). Moreover, atherosclerosis only develops at specific locations (branch points). You’re missing confounding variables
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simon clark
simon clark@simoncclark456·
@arhamgrowthcap @agingroy @Merck PCSK9 inhibitors increase the clearance rate of apoB particles from your blood. A lifetime of low apoB means a much lower risk of heart disease. Heart disease is the number 1 killer and cause of lost health span. Seems pretty good to me.
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Arham
Arham@arhamgrowthcap·
@agingroy @Merck Therapeutically and/or pharmaceutically nuking your lipids is imbecile behavior. Fine by me go ahead
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Dick26
Dick26@Dick26182748·
@simoncclark456 @ScobbleWobble @ScottAppliedSci Simon,8 weeks study that requires people to (over)eat muffins against millions of years of human experience and evolution thriving on saturated fat and meat?I know which one I pick. Call me arrogant but I will gladly disregard any study that does not pass the common sence tests
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Andrew Scott
Andrew Scott@ScottAppliedSci·
I cut all seed oils for over 10 years. I ate low carb and cooked in ghee, tallow and minimal olive oil (spray). Got fatter, sicker, and eventually diabetic. Switched to a mixed, carby, seed-oil-containing, calorie-restricted diet. Lost weight & diabetes in remission.
Sama Hoole@SamaHoole

Cutting seed oils: what people expect vs what actually happens. Expectation: this will be easy. Reality: seed oils are in everything. Crisps. Crackers. Bread. Salad dressing. Mayonnaise. Hummus. Pesto. Soup. Ready meals. Protein bars. Vegan cheese. Plant-based anything. Most restaurant food. All fast food. The "healthy" options at the health food shop. Nearly everything in a packet. Expectation: I'll just use olive oil instead. Reality: olive oil is fine. Unfortunately, it's often blended with cheaper seed oils. Make sure you trust the source. Expectation: I'll notice a difference in a few weeks. Reality: linoleic acid has a half-life in body fat of around 600 days. The seed oils you ate last year are still in your cell membranes right now. This is a two-year project minimum. Most people don't have that kind of patience and give up. Expectation: people will understand. Reality: you will be told you're worried about nothing, that seed oils are fine, that the science is settled, and that you should eat the hummus. The hummus has sunflower oil in it. Expectation: I'll just cook with tallow. Reality: this works perfectly. Buy it once. It lasts months. Costs less than olive oil. Cooks everything better. Tastes good. Expectation: I'll feel smug. Reality: yes. Unavoidably. This is one of the confirmed side effects.

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simon clark
simon clark@simoncclark456·
@DanielMcCa76021 @Tellit007 @thegarybrecka That was a failed experiment. It was supposed to last more than 5 years, it lasted only 1 because nearly all the participants left. In addition there was no control on what the participants who remained ate. And it was confounded by the veg spreads having Trans fats.
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Boca Boca
Boca Boca@DanielMcCa76021·
@Tellit007 @thegarybrecka Maybe yuu never heard of the Minnesota coronary study’s we have known for 50 years that replacing saturated fat with veg oil leads to more heart attacks and deaths.
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Tellit Likeitis
Tellit Likeitis@Tellit007·
Gary Brecka sells supplements. The oils he calls industrial lubricants reduce heart attacks in randomized trials. His supplements have no such record. Classic Gary. @thegarybrecka is a self-described human biologist, not a physician or lipidologist. His revenue comes from supplements, $600 genetic testing, and speaking circuits. Nice gig if you can get it, right? His content depends on a world where seed oils are the villain and his products are the solution. That is not a coincidence. Eight randomized controlled trials, 13,614 participants. When polyunsaturated fat replaced saturated fat, coronary heart disease events fell 19%. Mozaffarian et al., PLOS Medicine, 2010. The oils in that analysis include the canola, soybean, and sunflower oils he is calling the most destructive ingredient in the food supply. The outcome data runs opposite to his claim. The oxidation and omega-6 ratio arguments are mechanistic speculation deployed to bypass the trial evidence. Mechanisms that sound alarming in a post do not override randomized endpoints. He sure as heck is trying. If the oxidized PUFA hypothesis were correct, the 8 RCTs would have found harm. They found a 19% reduction in disease. Fascinating. @nationallipid on what the actual fat substitution data shows: replacing saturated fat with polyunsaturated fat reduces cardiovascular events. The labs Gary Brecka charges $600 to interpret do not change that finding. Do better.
Gary Brecka@thegarybrecka

Seed oils are the most consumed and most destructive ingredient in the modern food supply. Canola, soybean, sunflower, corn oil... these are industrial lubricants that were never meant to be eaten at scale. They are loaded with omega-6 linoleic acid, which oxidizes under heat, drives systemic inflammation, and disrupts your cell membranes. The omega-6 to omega-3 ratio in the average American diet is now 20:1. It should be 4:1. Read your labels. Remove seed oils. This single change will shift your inflammatory baseline.

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simon clark
simon clark@simoncclark456·
@PeterSmartpower @DaleVince You just need the HP and the emitters to be sized appropriately for the home's heat loss. The calc is done on a temperature of -2 celcius. Of course improve your insulation. That will help any home with any heat source be more comfortable.
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Peter Brennan
Peter Brennan@PeterSmartpower·
@DaleVince Heat pumps are only suitable for houses with high insulation levels. If the house is leaky with poor insulation, then the heat pump will have to work very hard.
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Dale Vince
Dale Vince@DaleVince·
This is a typical experience - heat pumps have been mis sold to us, bills typically go up not down and most people keep their gas boiler as back up - which removes one of the main cost savings that companies like Octopus bank on when claiming bills can come down. The real word experience of that pumps is massively at odds with the marketing claims of companies selling them. They can work, in ideal circumstances - if by ‘work’ we mean bring bills down. But it’s the exception not the rule. bbc.co.uk/news/articles/…
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simon clark
simon clark@simoncclark456·
@bleating_lamb Do you think that climate science has more money attached to it than the multi trillion dollar businesses of meat and dairy?
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