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@solodoc

Sic itur ad astra. “Life is a series of compromises I will lose precisely zero sleep over.” #alwayslookup https://t.co/1V0uNYaN9o

Biosphere Katılım Mayıs 2007
719 Takip Edilen461 Takipçiler
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tern
tern@1goodtern·
I'm feeling a little astonished to be backed up by the <checks notes> Daily Mail.
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rp@solodoc·
@_CatintheHat @ClareCraigPath This Dr Craig who minimised pandemic sars cov 2 deaths? bylinetimes.com/2021/04/01/bew… This study shows she’s wrong. Study x.com/solodoc/status…
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rp@solodoc

@atranscendedman Quite the study design using displaced pop. level mortality % ie who died earlier than they should then calculated how much it was displaced and controlled for confounding factors like HTN which appeared protective. tl:dr? it robbed people of years of life. Individually ~4yrs

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Cat in the Hat 🐈‍⬛ 🎩 🇬🇧
Cat in the Hat 🐈‍⬛ 🎩 🇬🇧@_CatintheHat·
@ClareCraigPath I refer you to the comment I made to you the other day, Dr Craig… ➡️ Absence of evidence does not equal evidence of absence. I’ve also just discovered your hashtag: #WrongAgainClare Amazing how many times you’ve been proven wrong.
Cat in the Hat 🐈‍⬛ 🎩 🇬🇧@_CatintheHat

@ClareCraigPath I feel like this quote from the Covid Inquiry M3 report was written specifically for people like you, Dr Craig 😊 “Some individuals have fallen victim to the fallacy that absence of evidence equates to evidence of absence.” “It was unwise to make such definitive statements.”

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Dr Clare Craig
Dr Clare Craig@ClareCraigPath·
It is terrifying that they are pushing the ideas of "super spreader events" and "asymptomatic transmission". It is all based off one study which showed clusters of infections - but totally failed to exclude coincidental environmental exposure. Why is this treated as gospel?
Abraar Karan@AbraarKaran

Thanks to the @nbc Today Show and @SavannahGuthrie for their in-depth look at the @NEJM 2018-19 Andes Virus study and for interviewing me on my thoughts here. Yes, this study did show that an infectious case of #AndesVirus can transmit to 5-10 additional people in crowded social settings. Yes, it is one study but it is also a clear counter-example to the "no spread from casual contact" narrative. We should be open about what is possible even if it doesn't happen all the time or with every case. Disease transmission has many factors involved, including how much virus the person is shedding at the time. #Hantavirus today.com/video/key-take…

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Dåve
Dåve@D_Bone·
@solodoc I'm not sure how you could - if you want to talk about science.
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Dåve
Dåve@D_Bone·
lol. Yeah… I’m sure they’re doing it.
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rp@solodoc·
@DrAnnieHickox @M_Moutoussis Simplistic but: Like psychoanalysis helps us understand what happens; neurology the where, why & how. Other aspects of psychology help us understand a person’s interactions with others & reality. Psychiatry looks at diagnoses, overlaps and treatment & brings it together.
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Dr Annie Hickox, Clinical Psychologist/Neuropsych
Dr Annie Hickox, Clinical Psychologist/Neuropsych@DrAnnieHickox·
@M_Moutoussis I agree, I grew up with psychoanalytic concepts as our father was treated for years by a psychoanalyst who helped him hugely with his psychotic depression. I believe neurology and psychoanalytic concepts intertwine well together.
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Michael; mastodon: @mmoutou@defcon.social
Michael; mastodon: @[email protected]@M_Moutoussis·
Important! I think there's masses of importance in psychoanalytic thinking, but the Rat Man, Freud's OC paradigmatic case, is not it. But also with caveat re danger of psychological vs. neurological dualism in OC!
Dr Annie Hickox, Clinical Psychologist/Neuropsych@DrAnnieHickox

Wonderful obituary for Judith Rapaport, whose work made such a difference to children suffering OCD. Rapaport correctly identified OCD as a neurological disorder, and not arising from a Freudian unconscious conflict as previously thought. @theguardian share.google/Rt1KKVtcpxVXsI…

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Joel Geerling
Joel Geerling@geerling_lab·
While some signs and symptoms help support or refute a diagnostic hypothesis, we don’t have objective tests to confirm or exclude (during life) most neurodegenerative diseases, including CTE. This makes it difficult to test treatments, beyond symptom management.
John D. Arena, MD@JohnDArenaMD

CTE cannot be diagnosed during life. Our work published today in @NatureMedicine demonstrates that most individuals meeting proposed clinical criteria do not have evidence of #CTE neuropathology at autopsy (1/5) rdcu.be/fiFKk @PennNSG @PennMedCSO @WillStewNeuro

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Elie Naddaf
Elie Naddaf@ElieNaddaf3·
A common problem for symptom-based diagnoses without a biomarker! This remains a major obstacle to advancing the field for many disorders as including samples from patients without the actual disease dilutes the findings and makes any study lose power to detect meaningful effects
John D. Arena, MD@JohnDArenaMD

CTE cannot be diagnosed during life. Our work published today in @NatureMedicine demonstrates that most individuals meeting proposed clinical criteria do not have evidence of #CTE neuropathology at autopsy (1/5) rdcu.be/fiFKk @PennNSG @PennMedCSO @WillStewNeuro

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rp@solodoc·
@DebHolloway @D_Bone Yes, a quick look at the site & the ME/CFS tag count =48, a search =67 Many more for LC Yet the COVID-19 tag also includes Covid forecasts AND a cursory look shows the first article “A test for Long COVID can’t leave anyone behind” mentions ME/CFS & separating them being hard.
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rp@solodoc·
@JuliaRansom3 @arijitchakrav Absolutely 💯. And they’ve been like that for ages. Hence the denial, minimisation, conflation.
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Arijit Chakravarty
Arijit Chakravarty@arijitchakrav·
I’m not a public health expert, so can someone please explain to me- ŵħát tħé fúçķ is wrong with these people? On what rational basis can this be justified as serving the interest of public health? 🧠 🪱 thehill.com/homenews/58769…
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Julia
Julia@JuliaRansom3·
@solodoc @arijitchakrav A conservative approach to quarantine which lets people not isolate. Much like the approach that got us where we are with C19 (and ended up killing my father) then. I could take an uneducated guess but I'll bow to your "not attempting to guess" approach.
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NEJM
NEJM@NEJM·
The hantavirus outbreak has raised two major concerns for @PaulSaxMD — and neither is directly related to the outbreak itself. Read the latest from Dr. Sax in NEJM Voices, a new clinician blog featuring short, personal essays grounded in real-world practice: voices.nejm.org/doi/full/10.10…
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rp@solodoc·
@JuliaRansom3 @arijitchakrav Thank you Julia. I’m not even going to attempt to make an educated guess here as I’m taking them at their word here. Bearing in mind that story in the Hill takes information from several sources AFAIK. Theirs is a “conservative approach.”
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Salvatore Mattera
Salvatore Mattera@SalvMattera·
Your first point is called the sorites fallacy. Let's say I didn't submit two mislabeled samples. Just forget about it entirely for a second. How do you know that someone else didn't do that? You don't. How do you know that someone won't do that in the future? You don't. How do you know that the people in the data have the diseases or the symptoms they claim to have? You don't. Maybe they misunderstood the question or just mark the wrong box or have a bad memory because brain fog. They use self report and chart tens of thousands of variables. To get anything worthwhile, you would need a massive number of samples. Their approach is incapable of producing anything worthwhile unless they get thousands of people to do it (assuming their lab work and science checks out). You're accusing me of destroying something that doesn't actually exist in the first place. You can't simultaneously argue that two mislabeled samples would catastrophically compromise the data AND that the data isn't already saturated with uncontrolled noise from self-report and misdiagnosis. So, until they get there (doubt it happens but who knows), all their interim findings are worthless, so whether I submit two mislabeled samples or not, it doesn't matter.
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MastcellMadness
MastcellMadness@MastcellMadness·
This would essentially be a data poisoning attack on Amatica. Maybe we could try not to actively sabotage efforts we don't agree with?
Salvatore Mattera@SalvMattera

Here's my idea for Amatica: I will purchase two tests and I will give them blood from the same healthy person on the same day but I will tell them it's two different people, one with LC and another with ME and see what the results come back as. I will use multiple intermediaries so they won't know it's me. Let's see what happens.

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NEJM
NEJM@NEJM·
In the phase 3 SCORPIO-PEP trial, the 3C-like protease inhibitor ensitrelvir was more effective than placebo in preventing Covid-19 in household contacts of patients with SARS-CoV-2 infection. Full trial results: nej.md/4npQqG7
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Keşfet

@1goodtern @_CatintheHat @ClareCraigPath @D_Bone @DrAnnieHickox @M_Moutoussis @DebHolloway @JuliaRansom3