Kristopher Stipech

first time using claude to write a legal contract "use plain english but ensure document is legally sound" incredible now just need a docusign integration

@benblumenrose incredibly well articulated

Companies are scrambling to get their design teams to move as fast as their now blazing fast engineering teams. But lots of design doesn't lend itself to this type of compression. It’s the insight you get on a walk. The connection from another field. The aha when using a product you love. It could be that for some design work the answer isn't to speed up... but actually to slow it way down.

@rsa @TIDAL fresh

New @Tidal player is rolling out. And another fun feature for artists later this week.

iykyk

@iamdavidhill every ceo thinks they value design

a ceo who doesn’t value design isn’t a very good ceo

@psomkar1 ragebait

Unpopular opinion If you can't code, you can't vibecode.

@avlok wow

Wow, beautifully said. ❤️

smashing the "1" key

@mjboswell very clean

For the past few months, we’ve been quietly building a standalone X Chat app for iOS. Today we’re opening it to the first 1,000 users on TestFlight. Use it. Break it. We want your feedback. Screenshot → ✓ → “Share Beta Feedback…” testflight.apple.com/join/2dxvn5Sv

you're wired to build a life worth living, lean into it

@Dustin_Hillis_ @elonmusk @boringcompany sadly nashville will never be a technology leader, it's a great city though

As a Nashville business leader who makes the commute from downtown to #BNA airport often… I fully support ⁦@elonmusk⁩ project with ⁦@boringcompany⁩ to provide quick access from the #Nashville airport to downtown! Nashville is the new #technology leader in the South!

@benjitaylor i want the mini menu bar app!

Readout is a fully native macOS app I’ve been building for myself. It provides a real-time overview of your dev environment and Claude Code config. All local, no account required. It's still very much a beta, but now available to try: readout.org

accurate

@GavinNewsom is this parody

Donald Trump has been illegally taxing your groceries, furniture, and cars for over a year. Time for a refund.

@marcrandolph didn't realize you're working on a new startup!

I work really hard at creating a place where "elite" talent wants to work. Hint: it's not nap pods and kombucha on tap. It's agency. It's honesty. It's surrounding them with other brilliant people.

Everything about cancer sucks. Some of the most difficult decisions in cancer are what to do and when to do it: biopsy, resection, passive monitoring etc. Today, clinicians make irreversible calls like 1) do a biopsy or wait, 2) treat or monitor or 3) remove an organ or monitor, using tests that cannot see the full biology of either the body or the cancer. As a result, doctors often overtreat the wrong patients while missing dangerous cancers in others until it’s too late. Five years ago, a sibling trio of Purdue grads cold emailed me from Indianapolis. Their thesis was simple: the science in cancer detection and treatment isn't the bottleneck. The engineering is. Fix the engineering, and you can change the standard of care of cancer forever. We founded @EarlyIsGood together to do this. Here is our mid-decade update after five years (!) of toil. We’ve made some good progress. 1. The Engineering Unlock: Multiomics Most diagnostics fail because they are looking for a needle in a haystack. The results are modest and create many false positives and false negatives. We developed nanotechnology that amplifies the needle making it simpler for us to figure out what is going on. Our nanotechnology allows us to read DNA, RNA, and Proteins simultaneously from a single sample. We detect Proteins at attomolar sensitivity (1000x ELISA) and RNAs at PCR-level sensitivity all without extraction or amplification. Combining all three provides a full picture because:  - DNA tells you what mutations are present
- RNA tells you what the cancer is doing
- Proteins tell you how the body is responding 2. The Proof: Bladder Cancer  We started here because the standard of care today is barbaric. 800,000 people are under surveillance for bladder cancer, enduring invasive cystoscopies that still miss ~20% of tumors. We are finishing a multisite prospective trial now. Standard of Care (Cystoscopy): invasive, repeated every 3-6 months. Our bladder cancer test (BCDx): 92% sensitivity and 97% specificity from a simple urine sample. Most importantly, we catch the high-grade tumors that the current gold standard misses completely. 3. The Next Mountain to Climb: Prostate Cancer

If you’ve watched a father, brother, or friend get a high PSA result, you know the spiral that follows: months of terror, invasive procedures, and paralyzing uncertainty. 20M+ PSA tests are run annually. Most positives are false alarms, leading to 1M+ unnecessary, painful biopsies. Meanwhile, dangerous cancers are often missed. Current commercial tests hover below 50% specificity. That means for every two men they flag, one is a false alarm. We partnered with the Mayo Clinic to solve this. No blood draws. No rectal exams. Just a simple urine test. We are using the same platform that we validated on bladder cancer to achieve unprecedented specificity without sacrificing sensitivity, effectively separating those who need treatment from those who don't.  We will soon be commercializing both our bladder and prostate cancer tests widely. Follow us @EarlyIsGood if you’d like to help or know when/where these tests are available.

Speed is a bug if you don't know what you're doing

the hottest new programming language is english

truly

@girdley maybe he's not one to unload his problems on a stranger at a party, especially one who will share said problems with the internet

Talking to a guy at a party. "Everything is great. Working on x, y, and z cool proejcts. Just bought a boat." Two days later hear the truth. Wife left him, kids hate him, and his business is barely alive.