Francesco Strati

Breaking the mold: Unconventional T cells in cancer therapy dlvr.it/TJRYrN

Tumor “age” in early-onset colorectal cancer @CellCellPress @Albert0Bardelli cell.com/cell/fulltext/…

Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation @NatImmunol nature.com/articles/s4159…

IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumor control @Nature nature.com/articles/s4158…

Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu doi.org/10.1073/pnas.2… @C_Boulouis @SandbergLabKI

There's no place like home: How local tissue microenvironments shape the function of ILC @MucosalImmunol @Lukuscyte doi.org/10.1016/j.muci…

Looking for a #postdoc position at the intersection of #cancer and the #microbiome? Join @Zimmermann_Lab @embl and @EMIL_DKFZ @DKFZ with a @ResearchLifesci #fellowship! Details and Application: health-life-sciences.de/opportunities/… (project #128, deadline 28th March)!

Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis nature.com/articles/s4158… #journals #feedly

Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes @J_Immunol academic.oup.com/jimmunol/advan…

Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective of a rapidly evolving field. @jclinicalinvest jci.org/articles/view/…

Boost Your Career in Immunology with the SMI Mentorship Program and connect with leading experts for career guidance, networking, and growth opportunities -> bit.ly/3orazy8 Also, hear from @RegisJoulia on the Mucosal Immunology Podcast: bit.ly/4hkDayE

We developed a 3-gene signature to identify tumor-specific CD8 TIL, i.e. the cells targeted by #immunotherapy, from #singlecell data. Out now in @NatureComms. All data & code are public. Please use it! #WomenInSTEM #science #research #datascience #AI nature.com/articles/s4146…

Wow! Great @NatureComms paper from @GarryPNolan @SizunJ @shaleklab Designing optimal 16s probes for integrated spatial profiling of microbiome & host spatial transcriptomics/proteomics. Microbiome Cartography or MicroCart for probe design can then be incorporated with various platforms.

Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies nature.com/articles/s4146…

New! Online now: Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy dlvr.it/THdf2n

MCT1 lactate transporter blockade re-invigorates anti-tumor immunity through metabolic rewiring of DCs in melanoma nature.com/articles/s4146…

1/ Let's do a deep dive into the best research article on Foxp3+ Tregs this month (January 2025) and highlight its strengths and weaknesses. #immunology #Tregs #allergy #microbiota #microbiome #Foxp3 nature.com/articles/s4158…

We studied antigen-specific CD8 T cells in the mouse small intestine with spatial transcriptomics out @Nature! You can find the paper here (bit.ly/42mAwDS) and Max's (bit.ly/3Q9dfOB) and Miguel's (bit.ly/3E8slRA) Bluesky threads on our work.

Preserved suppressive function despite loss of Foxp3: insights into the identity of regulatory T cells doi.org/10.1101/2025.0… @MichaelBonell10

#BtBsPUB "Estrogen-related differences in antitumor immunity and gut microbiome contribute to sexual dimorphism of colorectal cancer" by #StratiLab_BtBs #FacciottiLab_BtBs #BaeriLab_BtBs & co-authors. #BtBsUNIMIB @unimib pubmed.ncbi.nlm.nih.gov/39548749/