Histology Student

🔬Colonic biopsies from patient with a history of chronic diarrhoea and immunosuppression- cryptosporidium! #GIpath pathologyoutlines.com/topic/coloncry…

Here's an odd 🐦 Microscopic colitis pattern, but you find rows of giant cells and macrophages have accumulated in the upper mucosal reaches. Normal colonoscopy, no medication, usual reason to investigate. What's going on? #GIpath

Biopsies of a duodenal D1 polyp. More pictures in next tweet. Would be interested in how people would report this? Perhaps the ultimate label doesn't matter that much as I think it needs removal. #GIpath

Chronic mucosal injury is often seen overlying the diaphragms including gastric metaplasia (seen here) 2/2

Low power view of diaphragm disease highlights the difference in height between the diaphragms and the adjacent normal plicae circularis 🔬 #gipath 1/2

@miss_me1986 Low power view of diaphragm disease highlights the difference in height between the diaphragms and the adjacent normal plicae circularis 🔬

3/4 * There can be minimal inflammation and architectural distortion in the mucosa overlying or surrounding the diaphragms. The inflammation is usually limited to the submucosa and no granulomas/ lymphocytic aggregates are usually detected; an important point to keep in mind.

Middle aged female, presenting with small intestinal obstruction. Very characteristic macroscopic picture. Micro to follow.... #grossognosis #gipath

Donor gallbladder from HIV+ patient. What is your diagnosis? Differential? Answer to follow. #gipath @UTSW_GIpath @CArnold_GI @drdoubleb @ALBoothMD @Purvago @SuntreaHammer

Submucosal infiltration in ESD specimens often provokes extensive fraying of the muscularis mucosae. Measure infiltration depth from deepest fibre MM, true volume of disease often larger than raw depth indicates. Here 620 micron, T1b SM2, 15% risk LNs gut.bmj.com/content/68/9/1…

#PathPitfall, Frozens Edition: We often freeze nodules on the liver looking for mets. When we see a proliferation of glands in the liver, a knee-jerk response is: metastatic adenoca! BUT don't forget our friend bile duct hamartoma- common, often incidentally found, and benign!

Incredible example of a TFE3-rearranged PEComa that presented as a colorectal polyp.

Another entry for our competition in celebration of @RCPath National #PathologyWeek from Sarah in Cellular Pathology, with the proof that pathology truly is at the #HeartOfHealthcare 💜🔬

These 'thickened gastric folds' in a 50yo man showed 4 different diagnoses, all of them benign 😀 🕐 Superficial active gastritis (see those neutrophils! HP present, not shown 🕑 Intestinal metaplasia, non dysplastic (probably related to atrophy) (Cont.) #gipath #pathology

Hey #Pathologists, what do you think of this enlarged inguinal lymph node from 62 yo male with CLL? Part of node shows SLL/CLL but part is necrotic and edematous. What’s going on?

Jejunum biopsy. Clearly an unhappy piece of mucosa. What do you see? Or rather, what do you NOT see? #pathology #gipath

1 of 2 1D Diagnosis: Esoph leukoplakia/epidermoid metaplasia Pearls: -endoscopic findings: plaque (may come as "r/o candida"); if diffuse, consider Tylosis -histologic criteria: orthokeratosis & granular layer

An unusual colorectal perineurioma with meningothelial-like whorls. Our Intestines Fascicle covers these but the treat is the polyps section by Dale Snover, who "invented" the sessile serrated adenoma, now renamed as sessile serrated lesion by the WHO. arppress.org

h. pylori vs h. heilmannii: HP: common, gram neg, 3.5 um, curved rod. 80% of infected pts asymptomatic. HH: rare, gram neg, 5-9 um, tight spirals. Human infection is zoonotic, from household pets or farm animals. Antibiotic therapy similar to HP. #gipath #gibugs #pathology

Case of the week (contributed by Dr. Chirag Patel): The patient is a 45 year old HIV+ Male with hematemesis and weight loss. Endoscopy reveals maroon-red distal esophageal plaques and nodules. Microscopic examination reveals the following. Diagnosis?

When a gallbladder looks this nasty, consider IgG4-related fibrosclerosing disease.

This inflammatory fibroid polyp of the colon either induced low-grade dysplasia in the overlying epithelium, or arose within a pre-existing focus of dysplasia. Doesn't happen often! bit.ly/2SHELUz #pathology #gipath

Elderly ♂️ with anal/perianal mass. Incisional biopsy. What's your favoured diagnosis? #GIpath #pathology