Jonathan Swerdlin
309 posts

Jonathan Swerdlin
@swerdlin
My life's work is to keep people healthy. Co-founder @function

Function identified early indicators of ASCVD that led to a preventative plan at 36 versus waiting several more years to identify it. I have a pretty clear plan and starting to see biomarkers improve. I don’t care if they haven’t proven something in a paper - it’s been a impactful experience for me.





Okay sick. Robinhood just launched a Platinum Card and it's be looking like the single best credit card deal out there The best perk: Function Health. It's 100+ lab tests covering organ function to cancer markers. The kind of panel insurance won't cover. Normally costs $499/year. Now included. The card's annual fee is $695. So after one perk, you're $196 away from breaking even. Then stack on: - $250 in DoorDash credits + DashPass - $200/year for Whoop or other wearables - Free Amazon One Medical - Unlimited Priority Pass lounges - 5% back on flights AND restaurants It also doesn't force the stupid miles game, every dollar earned goes directly into your brokerage account as cash to invest. Not even paid to say this i'm just excited to not need to pay $900 for my Amex anymore



The FDA just made one of the most significant shifts in its evidentiary standards in decades—and it feels like a lot of people have slept on the news! The FDA will now default to ONE pivotal trial for drug approval, not two. The science of evaluating whether a drug works has advanced enormously. Today, development programs build evidence across multiple dimensions—mechanism of action, biomarker effects, intermediate endpoints—that collectively tell a more complete story. That body of confirmatory evidence, from mechanistic data to real-world evidence, can replace a second pivotal trial. We have historically seen more regulatory flexibility in rare diseases and oncology where need is acute. But the biggest impact we expect to see with the shift from two to one pivotal trial is likely to be in common conditions like cardiovascular and respiratory where the two pivotal trial dogma has been more entrenched. Potentially up to $350M in savings per program and years off timelines. And this might just be the start—could continuous trial designs that collapse the rigid phase structure be the next paradigm shift in clinical development?




Key study of Grail’s cancer detection test fails in setback for company While the test, called Galleri, showed some benefits, results are likely to fuel debate on technology statnews.com/2026/02/19/gra…













