Frogger 🐸

Salt increases blood pressure (when it does) by attracting water into the blood, increasing the volume of blood pushing out against the blood vessel wall. You can’t replicate this by dumping salt onto isolated endothelial cells because you don’t have an intact blood supply inside a closed lumen. Inflammation responds to this to increase vascular permeability, allowing blood to leak out of the vessels. This lowers blood pressure directly and in the kidney it helps get rid of salt in the urine. If you get sepsis, for example, the inflammation causes low blood pressure. This paper is using vague terms like “endothelial dysfunction” to describe this totally adaptative inflammatory process and then trying to claim that salt doesn’t do anything directly but in fact it’s all driven by inflammation and cellular senescence. This is total nonsense. Salt attracts water. This is basic chemistry with innumerable real-world applications as ancient and basic as drying meat or using salt as an antimicrobial. There is nothing going on fundamentally with this except the transfer of water. Everything else is secondary to this. Potassium ABOLISHES the effect of salt on blood pressure by moving the water into your cells. If it goes in the cells, it doesn’t stay in the plasma. Plasma volume goes down, so blood pressure goes down. But these people are trying to sell an experimental “senolytic” drug navitoclax by claiming that salt acts though some complicated process of cellular senescence to raise blood pressure. But it doesn’t. It raises blood pressure by drawing water into the plasma. Sustained high blood pressure causes senescence to the endothelial cells because high blood pressure is bad for them. The catch: if you draw the water into your cells with a 1:1 ratio of potassium to sodium you hydrate your cells instead of raising your blood pressure. Not because potassium has fancy immunomodulating senolytic gibberish about it but because it moves water to where it belongs.

The year is 1950. Your doctor lights a cigarette and tells you smoking is fine. He read it in a study. He is telling the truth about having read it. He does not know, or is not saying, that the study was funded by the tobacco industry. The year is 1958. Your doctor tells you to eat less fat. The evidence is contested. The contestation is not in the public messaging. The food industry has been helpful in clarifying which findings deserve attention. Some researchers who published contradictory data have been quietly defunded. Ancel Keys is on the cover of Time magazine. The year is 1962. Your doctor prescribes thalidomide to your pregnant wife for morning sickness. It has been approved. The FDA gave it the green light in Europe. Twelve thousand children will be born with severe limb malformations before anyone in an official capacity acknowledges the problem. The families are told the drug was safe. The drug was approved. Both of these things remain true. The year is 1972. Your doctor prescribes Valium. Britain is in the grip of a benzodiazepine wave that will last two decades. The dependency risk is known internally. It is not shared. Your doctor is not lying to you. He was not told either. The year is 1999. Your doctor prescribes Vioxx for your arthritis. It is newer than ibuprofen, well-tolerated, and Merck has a study showing it works. Merck also has internal data suggesting it roughly doubles the risk of heart attack. This data will not reach your doctor for four more years. Fifty thousand people are estimated to have died in the interim. Merck eventually settles for 4.85 billion dollars. No criminal charges are brought. The year is 2002. Your doctor prescribes OxyContin. Purdue Pharma trained its sales representatives to tell doctors the addiction risk was less than one percent. That figure came from a letter, not a study. The letter was about patients with terminal cancer on short-term doses in hospital settings. Your doctor is a GP with a patient who has a bad back. Nobody draws a distinction. Nobody is required to. The year is 2008. Your doctor checks your cholesterol. Your LDL is elevated. You are prescribed a statin. Nobody mentions that the number needed to treat for primary prevention is approximately 250. Nobody mentions that the muscle deterioration you'll notice over the next two years is listed as a rare side effect rather than a documented pattern affecting a meaningful percentage of patients. The trial that informed the prescription was funded by the manufacturer. Now it is today. Your doctor has new guidelines. New studies. New consensus. He is confident. He has always been confident. The confidence has never been the problem. The confidence is, in fact, precisely the problem.

NEW: 🇱🇧🇮🇱 Israel has destroyed the hospital in Tebnine, southern Lebanon with a direct airstrike

This is one of those tweets that keeps deleting the likes. It’s about the PCR fraud and how our reviewer testified against Wakefield for the exact same faults they defend in the Drosten PCR protocol. I wonder if it will get more traction in the new world?

Sure. In a nutshell, Orbán being purged is significant. The force that blocked Ukraine funding through Russian-sanctioned assets, and resisted Israel–EU trade blocks due to illegal settlements, is removed. That’s good for the military-industrial complex profits with regards to Russia. But it’s bad for the profitable “forever war” model of the military-industrial complex in the Middle East. That’s the trade-off. Both sides get unlocked. The EU gets more war. The Middle East moves closer toward a framework for regional stability after the Iran war. The financial-industrial complex gains full control over the EU, which was always the endgame of the Bank for International Settlements when they created the $EUR single currency. EU central bank digital currencies accelerate, aligning with the technical-industrial complex. What happens in the EU becomes the beta test for what the financial-industrial complex aims to implement in the US MIC civil unrest campaign as we transition to a multipolar world. This accelerates FIC control of the west.

Public Service Announcement- There are still physicians out there that can’t pass a high school biology class. There is no nuclear envelope during cell division and nuclear targeting sequences guarantee this DNA ends up in the nucleus even during other stages of the cell cycle.

Checked and this is real. There isn't a single city, town, or village with a label south of Beirut at any zoom level except for Tyre and Saida.

自動翻訳機能があるから、世界中の人に聞きたいけど、コロナワクチン接種により体調を崩した人はどれだけいるの？ コメントでも教えて

The US supreme leader is threatening to blockade the Strait of Hormuz and to attack any vessel trying to enter or exist the waterway, including ships that pay Iran toll fee, essentially threatening to hold the world economy hostage, while accusing Iran of extortion in the clusterfck of his own making.

@RenegadeOomfie Burgers aren't ready to accept that their country is Mystery Babylon and it's founded on blood and tears of natives, slaves, hawaians, hispanoamericans and even other euros that were subjugated into the Union like spaniards, frenchies and certain brits.

There hasn't been a coup. This is what the united states is. This is what it has always been. If you believe otherwise you do not understand the history of the united states. It was founded on lies and deception, and is still ran that way.

Your N = 1 is more relevant to you than any RCT will ever be.

23 mins in. Rough recording but shows you Makis true colors. I wouldn’t be posting this if it were not for Makis posting a Substack that entirely edited out my critiques of him and erected a false argument about this.

Erythritol is in every keto protein bar, every "zero sugar" energy drink, and every stevia packet on your table. The FDA approved it in 2001. A $275 million market. And researchers just watched it destroy brain blood vessel cells in three hours at the dose you get from a single drink. Here's what happened at the cellular level. University of Colorado Boulder exposed human brain microvascular endothelial cells to 6 millimolar erythritol, the concentration in one sugar-free beverage. Reactive oxygen species production doubled. Nitric oxide, the molecule that keeps your blood vessels relaxed and open, dropped 20%. Endothelin-1, the most potent vasoconstrictor your endothelium produces, jumped 30%. And when they challenged the cells with thrombin to simulate a clotting event, the cells' ability to produce t-PA, the enzyme that dissolves blood clots, was completely blunted. Less vessel relaxation. More vessel constriction. Worse clot-busting capacity. That's three independent pathways to stroke, all triggered by a single serving. This isn't the first signal. Cleveland Clinic tracked 4,000+ patients in 2023 and found those with the highest blood erythritol levels were roughly twice as likely to suffer a heart attack or stroke over three years. Two times the risk. On par with diabetes as a cardiac risk factor. And erythritol doesn't metabolize. Your body absorbs it in the small intestine, dumps it into the bloodstream, and excretes it through urine almost completely intact. Every serving stacks on the last one. The population most aggressively consuming erythritol, people with obesity, diabetes, and metabolic syndrome, is the exact population with the highest baseline cardiovascular risk. The sweetener marketed as their safe alternative may be compounding the problem it was sold to solve.

William Makis pushed the COVID vaccines until he saw there was more money for him in "fighting for medical freedom." Up until late 2021, he was pushing boosters. Then suddenly, his tune changed. Here are some of the posts he deleted. 🧵

I'm disgusted by his behaviour since you wrote your article for which he decided to blame everybody around you including those that had nothing to do with it. He then started sending defamatory and predatory DMs to our friends. I had actually tried to keep out of it until then. For the record I want everybody to be able to access any drugs that can help them under right to try and have expressed my disdain for the 4 universities who suppressed the patents that they applied for relating to cancer treatment using these drugs. That means no paywall. No secret protocols. No hiding behind a substack. Just let the people access safe drugs in a safe manner. How difficult can it be? @MaryBowdenMD

👇 Saludos, @presidenciacr y @seguridadcrc: ¿para cuándo declarar "terroristas" a los carteles de narcosicariato, de préstamos gota a gota y de trata de personas que nos tienen teñidos de sangre y crimen? 🔥 ¿O a esos criminales organizados no se les declara "terroristas" (aunque viven aterrorizando a la ciudadanía costarricense cuyos impuestos financian al gobierno CR vergonzosamente lacayo de USA) porque hacerlo no da puntos con "Papi Trump", cuyo país genera la mayor demanda mundial de drogas ilegales y de tráfico de personas, fomentando así el baño diario de sangre y violencia en el nuestro? 📣 Quedamos atentos. 🇨🇷 #ProhibidoOlvidar ⚖️ #ProhibidoPerdonar

True bench to bedside work. Kevin was talking about the amyloidosis risk nearly 5 years ago. Many people mocked him. Now its seems like they may have the only method to really rid of these things.

RT: Benjamin @netanyahu is one of the biggest threats to indigenous Middle Eastern Christian communities today. *He lied regarding WMD to force the Iraq War - resulting in 1.3 million destroyed Chaldean Christians in Iraq. *Pushed for the ISIS invasion of Chaldean & Syriac Christian towns in Northern Iraq in 2014. *Pushed for the Syria War, resulting in 2.0+ million destroyed Greek Orthodox, Armenian, Syrian Christians. *Armed Azerbaijan to ethnically cleanse Armenian Christians.

@RenegadeOomfie Well then there's only one thing to do, sleep the hunger off until you can get something.

@syrupfrogger no food in home empty fridge empty pantry only emergency stash so no

I hunger

@RenegadeOomfie Do you have any kind of noodles and black pepper? That with some butter and a bit of honey can be top tier in hunger time. If you don't have honey, just butter+pepper can do the trick.

@syrupfrogger I have some cans of food stored up but theyre not for eating in non emergency. Im itching for something tasty and forgot to go to store before easter x-x