The Longevist

The new jet lag recovery protocol worked. > I flew to Australia > met Kate's fam > became part of the fam ftw > flew home > jet lag broke my body's clock > felt broken inside > 300 mg of caffeine in am > 3 mg of melatonin before bed Watched my body's clock come back online, live, via blood glucose. Protocol accelerated body clock synchronization.

Midjourney pivoted to healthcare, full information : - It launched “Midjourney Medical,” building a full-body ultrasound CT scanner that lowers users into water and scans them with ultrasonic waves - The goal is to get 3D body maps in 60 secs, using hundreds of thousands of sensor elements + massive compute to reconstruct tissue density/stiffness - First use case is body composition mapping, not diagnosis, FDA approval is needed for broader medical claims - Big ambition is upto 50,000 scanners by 2031 and up to 1B scans/month, but radiologists warn about false positives, privacy & over-scanning risks

A technical dive inside our new "Midjourney Scanner"

Midjourney pivoted to healthcare, full information : - It launched “Midjourney Medical,” building a full-body ultrasound CT scanner that lowers users into water and scans them with ultrasonic waves - The goal is to get 3D body maps in 60 secs, using hundreds of thousands of sensor elements + massive compute to reconstruct tissue density/stiffness - First use case is body composition mapping, not diagnosis, FDA approval is needed for broader medical claims - Big ambition is upto 50,000 scanners by 2031 and up to 1B scans/month, but radiologists warn about false positives, privacy & over-scanning risks

OpenAI solved hardest childhood genetic diseases : - Boston Children’s Hospital, Harvard & OpenAI used o3 Deep Research to reanalyze 376 previously unsolved rare genetic disease cases - The model reviewed de-identified clinical/genomic data, HPO terms, family inheritance patterns, variant effects, ClinVar evidence & scientific literature - After expert review + CLIA lab confirmation, physicians established 18 diagnoses, a 4.8% extra diagnostic yield - Before unsolved cases, the workflow recovered correct diagnoses in 48/51 solved rare-disease cases and 45/57 neuromuscular cases

OpenAI solved hardest childhood genetic diseases : - Boston Children’s Hospital, Harvard & OpenAI used o3 Deep Research to reanalyze 376 previously unsolved rare genetic disease cases - The model reviewed de-identified clinical/genomic data, HPO terms, family inheritance patterns, variant effects, ClinVar evidence & scientific literature - After expert review + CLIA lab confirmation, physicians established 18 diagnoses, a 4.8% extra diagnostic yield - Before unsolved cases, the workflow recovered correct diagnoses in 48/51 solved rare-disease cases and 45/57 neuromuscular cases

Here's Bryan Johnson's 44% jet lag recovery protocol: - The protocol: 300mg slow-release caffeine in the morning & 3mg melatonin before bed after eastbound travel - The original study used 5mg melatonin, but Johnson suspects lower doses (0.3–0.5mg) may be sufficient & potentially more effective - Johnson believes circadian disruption affects cortisol, recovery, cognition and metabolic health, which is why he treats jet lag as a biological stressor - Research shows timed caffeine and melatonin can reduce jet lag symptoms, improve alertness and speed circadian realignment after long-haul flights

Here's Bryan Johnson's 44% jet lag recovery protocol: - The protocol: 300mg slow-release caffeine in the morning & 3mg melatonin before bed after eastbound travel - The original study used 5mg melatonin, but Johnson suspects lower doses (0.3–0.5mg) may be sufficient & potentially more effective - Johnson believes circadian disruption affects cortisol, recovery, cognition and metabolic health, which is why he treats jet lag as a biological stressor - Research shows timed caffeine and melatonin can reduce jet lag symptoms, improve alertness and speed circadian realignment after long-haul flights

How effective are Omega-3 supplements for brain? - Omega-3s (DHA & EPA) are critical for brain health and are found in fish oil and algae oil - Some studies link higher omega-3 levels to lower risks of cognitive decline and dementia - However, large clinical trials have produced mixed results with limited benefits seen in the general population - Researchers believe omega-3s may work best before significant brain damage occurs or in people with low baseline omega-3 levels - Omega-3s support brain health, but they're not a proven cure or guaranteed shield against Alzheimer's

OpenAI made a real scientific discovery in a chemistry lab : - Team targeted a palladium catalyzed cross coupling reaction, a core step used to synthesize drug molecules - AI analyzed reaction pathways, catalyst loading, solvent selection and temperature conditions to identify higher yield configurations - The system proposed novel experimental conditions that human chemists had not prioritized, leading to measurable reaction improvements in the lab - Every AI generated hypothesis was tested experimentally, creating a closed loop workflow between AI reasoning and real world chemistry

New study raises Alzheimer's concerns around a popular joint supplement : - University of Florida researchers analyzed 12 years of health records and found glucosamine users with MCI were 25% more likely to develop Alzheimer's - In people already diagnosed with dementia, glucosamine use was linked to a 25% higher mortality risk - Researchers identified hyperglycosylation ("sugar-tagging" of proteins) as a potential driver of the disease - Glucosamine crosses the blood-brain barrier and may worsen metabolic dysfunction in vulnerable brains

New study raises Alzheimer's concerns around a popular joint supplement : - University of Florida researchers analyzed 12 years of health records and found glucosamine users with MCI were 25% more likely to develop Alzheimer's - In people already diagnosed with dementia, glucosamine use was linked to a 25% higher mortality risk - Researchers identified hyperglycosylation ("sugar-tagging" of proteins) as a potential driver of the disease - Glucosamine crosses the blood-brain barrier and may worsen metabolic dysfunction in vulnerable brains

Person received world's first age-reversal therapy : - Boston-based Life Biosciences treated the first patient with a gene therapy designed to make aging cells behave younger again - The therapy uses 3 "Yamanaka factors" (OSK) that can partially reset a cell's epigenetic age without turning it into a stem cell - The first trial targets optic neuropathies by injecting the treatment directly into the eye, followed by a 6 months safety evaluation - In animal studies, similar cellular reprogramming restored vision, rejuvenated tissues & reversed biological markers of aging

Person received world's first age-reversal therapy : - Boston-based Life Biosciences treated the first patient with a gene therapy designed to make aging cells behave younger again - The therapy uses 3 "Yamanaka factors" (OSK) that can partially reset a cell's epigenetic age without turning it into a stem cell - The first trial targets optic neuropathies by injecting the treatment directly into the eye, followed by a 6 months safety evaluation - In animal studies, similar cellular reprogramming restored vision, rejuvenated tissues & reversed biological markers of aging

Cannabis users had 23% higher testosterone, here's why : - Researchers from the University of Geneva analyzed 94 healthy men (47 users, 47 non users) & measured 70 steroid hormones - Cannabis users showed 23% higher testosterone, along with higher DHT & androstenedione levels - The increase appeared to come from Leydig cells in the testes, the body's primary testosterone producing cells - Researchers suggest cannabis may influence hormone production, though men with naturally higher testosterone may also be more likely to use cannabis