Vadim Zipunnikov 🇺🇦

Tomorrow, Weds., 3/11 at #ICFSR26 .@ICFSRcongress In-person & virtual attendance options are still open! Register here: frailty-sarcopenia.com

🆕 @CellCellPress How restoring circadian rhythm slows aging biomarkers, extends healthspan and lifespan (at least in male mice!) cell.com/cell/abstract/…

Some men don’t actually “grow out of ADHD” They just marry women who keep their life organized and end up taking on a caregiver role

Can We Prevent Dementia? Science Says Yes 1. Cognitive reserve protects your brain by reducing blood vessel damage, lowering chronic inflammation, and keeping senses sharp. 2. Mental, physical, and social activity strengthen this reserve and build resilience. 3. Hearing loss and depression are major risks. Fixing them could prevent almost half of dementia cases. 4. Life-course habits matter. Small daily actions over decades add up. Could AI tools for work, summarizing, and learning boost brain stimulation and lower dementia risk?

The time of day for cancer immunotherapy is associated with major outcomes. Early is better. Results from a randomized trial of lung cancer, backs up the importance of our circadian rhythm and immune system nature.com/articles/s4159…

💥 Today we’re introducing Prism—a free, AI-native workspace for scientists to write and collaborate on research, powered by GPT-5.2. Accelerating science requires progress on two fronts: 1. Frontier AI models that use scientific tools and can tackle the hardest problems 2. Integrating that AI into the products scientists use every day Prism is free to anyone with a ChatGPT account, with unlimited projects and collaborators. Try it today at prism.openai.com—would love to hear your feedback.

By age 60, most people have lost nearly 50% of their peak physical capacity. A new study followed the same people for nearly 50 years and found that aerobic capacity and muscle power peak early (before age 40) and decline 1-2% per year after that. I write about it in today's newsletter. physiologicallyspeaking.com/p/physiology-f…

@SatchinPanda Interestingly, hand grip strength also shows daily rhythmicity: tandfonline.com/doi/full/10.10…

Average male reaches his peak median grip strength of 51 kg between the age of 29-39y Average female reaches her peak median grip strength of 31 kg between the age of 26-42y sciencedirect.com/science/articl…

A 5★ new review of the GLP-1 drugs, what they have achieved, and where the field is headed with so many new molecules and combinations @TheLancet thelancet.com/journals/lance…

FDA is now open to Bayesian statistical approaches. A leap forward! Bayesian statistics can help: ✅ Clinical trial design ✅ Finding the optimal dose ✅ Extrapolation to children ✅ Leveraging phase 2 results in phase 3

Can you sleep extra to bank it, so that you can sleep less in the future and still be productive? Great discussion in the journal "Sleep". academic.oup.com/sleep/article/…

What sets the maximal human lifespan, and why is it so rigid? In a new preprint, we discover a fundamental decoupling between the parameters that govern health vs those that govern maximum lifespan. Work by @BShenhar

Exposure to natural daylight that is ~5 times brighter and have plenty of light in 460-520nm spectrum than the typical fluorescent or LED light in offices improves metabolism. @Cell_Metabolism cell.com/cell-metabolis…

MIT’s UnDark published this interview with me discussing my new white paper on the U.S. vaccine safety monitoring system. The article only includes some excerpts from the full interview, which include: 1. discussing some of the ways these data are sometimes misinterpreted or misrepresented 2. discussing SARS-CoV-2 mRNA vaccines and myocarditis, the initial approval of vaccines for 12-15yr old population, and the Korean population level myocarditis study 3. One of my suggestions for improving analysis of Vaers. 4. Net benefit of vaccination after rollout in 2021 5. Factors to evaluate the case report based analysis of VAERs deaths that the FDA has performed and whose details are expected at the end of this month @Sara_Talpos @undarkmag @APPCPenn @UPennDBEI @PennMedicine @upenn @PennMedNews @PennMedCSO

The Science of Sleep

AI can help explain complex topics easily by throwing together a simulation. As Eric says later in the thread, a newer paper argues that this pattern is actually collider bias (the authors disagree). What is collider bias? Gemini one-shots an explanation: gemini.google.com/share/d8c33648…

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Just published 🔥 𝗡𝗲𝘂𝗿𝗼𝗹𝗼𝗴𝗶𝗰𝗮𝗹 𝗘𝘅𝗮𝗺𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗳𝗼𝗿 𝗖𝗲𝗿𝘃𝗶𝗰𝗮𝗹 𝗥𝗮𝗱𝗶𝗰𝘂𝗹𝗼𝗽𝗮𝘁𝗵𝘆: 𝗔 𝗦𝗰𝗼𝗽𝗶𝗻𝗴 pubmed.ncbi.nlm.nih.gov/40188056/ ☑️𝗯𝗲𝘀𝘁 𝘂𝘀𝗲𝗱 𝘁𝗼 𝗿𝘂𝗹𝗲 𝗶𝗻 𝗿𝗮𝘁𝗵𝗲𝗿 𝘁𝗵𝗮𝗻 𝘁𝗼 𝗿𝘂𝗹𝗲 𝗼𝘂𝘁! 📷shop.elsevier.com/books/millers-…

A fantastic comprehensive review article w/ everything you need to know about Idiopathic Normal-Pressure Hydrocephalus just dropped in the NEJM. Hydrocephalus refers to a condition where cerebrospinal fluid accumulates excessively in the brain’s ventricles, resulting in enlarged chambers that contribute to disrupting walking, cognition and bladder control. Johnson and Williams describe in their new New England Journal of Medicine paper that idiopathic normal-pressure hydrocephalus is a common, frequently missed and potentially reversible neurologic condition in older adults. Key Points: -Idiopathic normal-pressure hydrocephalus presents w/ a triad of gait and balance changes, urinary urgency and cognitive slowing, however each feature has an extensive differential diagnosis on its own. - Prognostic testing w/ cerebrospinal fluid drainage or infusion methods improves selection of candidates who are likely to benefit from shunt surgery. - Programmable cerebrospinal fluid shunt systems remain the most effective treatment and can improve gait quality of life and survival when used in appropriately selected folks. My take: Nailing the diagnosis is so important in iNPH, and it is frequently a tricky endeavor for even an experienced clinician. One thing I would add to this article is that a fair number of folks with 'big ventricles' actually have Parkinson's disease, so don't forget considering the possibility of a levodopa trial in select persons who present for shunting. Here are 5 points that resonated w/ me: 1- Recognizing the gait pattern is essential because a wide-based slow shuffling walk frequently precedes memory or bladder issues and can be the earliest clue. 2- Imaging matters ,however it is not enough since enlarged ventricles alone do not confirm the diagnosis and this finding needs to be paired w/ symptoms and w/ testing. 3- A large-volume lumbar puncture can help by temporarily improving walking, which usually signals a higher likelihood of responding to a shunt. 4- Shunt surgery can meaningfully improve daily function, especially the gait and fall risk. Importantly, it should be performed at experienced centers using adjustable valves. 5- Delays in diagnosis can worsen outcomes because waiting too long may reduce the chance of symptom improvement and increase long-term disability. nejm.org/doi/full/10.10… @NEJM @movedisorder @FixelInstitute @UF @SfNtweets @ParkinsonDotOrg @PdAvengers @DBSThinkTank

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