Travis Mallard

🧬🧠 Check out our latest preprint on the genetics of impulsivity! medrxiv.org/content/10.110… In this paper, we examined ‘lumping’ versus ‘splitting’ models of impulsivity and characterized the shared and unique biology across multiple levels. A few key findings below! 🧵

Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/2026.…

Excited to report our study in @NEJM on the discovery of deletions in a long noncoding RNA gene 🧬 (𝘊𝘏𝘈𝘚𝘌𝘙𝘙) as the cause of a newly defined human neurodevelopmental disorder 🧠. 🧵1/10 nejm.org/doi/full/10.10…

Having referred to it a few times this week, here is a (IMO) slightly more user friendly derivation of the LD-score regression estimator of heritability and its assumptions: gusevlab.org/projects/hsq/l…

Our paper (@bogglerapture @damadam, @dmoracze , Siyuan Liu, @wakeworksleep) on sex differences in the genetic architecture of the human brain anatomy is now out in @NatureComms @SpringerNature ! rdcu.be/dTUX1 Please see original post below for details…

It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file can be opened on powerpoint and it will be completely vectorized, even text are still recognized as text boxes! No more recreating plots on illustrator!!!!!

Yesterday I wrote a thread about why an infographic circulating was misinformation. I wanted to respond to some comments and questions, offer a new (perhaps more intuitive) calculation (thread)

Excited to share that our new paper in Nature Genetics! Huge thanks to @hailianghuang and @getian107 for supervising this project and to @broadinstitute, @CGM_MGH and @PGCgenetics for supporting the research. rdcu.be/dR0sF

🧠NEW WORK OUT NOW ON THE ARCHITECTURE OF HUMAN CORTICAL FOLDING ! 🧠 in ⁦@NeuroCellPress⁩ by the one and only ⁦@will_snyder98⁩ 🤩 wt dream team ⁦@petra_vertes⁩ ⁦@edbullmore⁩ & fab collabs. 👀🔗& Will’s 🧵⬇️ x.com/will_snyder98/… cell.com/neuron/fulltex…

Excited to share my 1st-author work from the @arbelharpak Lab! We examine the accuracy of polygenic score (PGS) predictions across individuals in the UK Biobank. We make 3 observations that expose gaps in our understanding of PGS “portability”. biorxiv.org/content/10.110… (1/28)

"Here, we present two real-world examples demonstrating that sample overlap and relatedness is not a minor or theoretical concern but an important potential source of bias in PRS studies." Ellis et al. AJHG cell.com/ajhg/abstract/…

Introducing real-time PRS-CS! Excited to share our new preprint with @getian107. Optimized for healthcare settings, rtPRS-CS ensures patients receive the most up-to-date genetic risk prediction by dynamically updating PRS weights using streaming data. 1/7 medrxiv.org/content/10.110…

Our paper is now available in @NatMentHealth! 🤩

‼️ Paper alert ‼️ "Deciphering the functional specialization of whole-brain spatiomolecular gradients in the adult brain" now published in PNAS!! How is brain function organized? Regions vs. gradients? Geodesic vs geometric? We add to the debate! pnas.org/doi/10.1073/pn… 1/

New out in Nature!! With age, women can lose one X chromosome in their leukocytes. What’s the cause/consequence? How does it differ from the loss of the Y chromosome in men? nature.com/articles/s4158… @broadinstitute @FinnGen_FI @FIMM_UH @theNCI @Cambridge_Uni

New paper "Alcohol consumption and the risk of all-cause and cause-specific mortality—a linear and nonlinear Mendelian randomization study" at @IntJEpidemiol: academic.oup.com/ije/article/53… led by Nigussie Kassaw and Elina Hyppönen. Brief thread:

4 years ago, we ran 16,554 GWASes for 7,271 traits across 6 ancestry groups and released the data to the public along with meta-analysis. After many careful dives through the results, we are happy to present these analyses on behalf of the Pan-UKB Project: medrxiv.org/content/10.110…

The genetic ancestry labels that the NIH “All of Us” biobank genetic data returns seem likely to add to general confusion about genetics and race/ethnicity [see appendix A here: researchallofus.org/wp-content/the…] 1/n

Presenting µBrain: a 3D atlas of @AllenInstitute histological slices of the developing brain, and tools for aligning gene expression/brain imaging! A beautiful labor of love led by @garedaba @DevelopingHCP @StuartJOldham @Aaron_A_B @emrobSci & others! biorxiv.org/content/10.110…

Distinguishing different psychiatric disorders using DDx-PRS medrxiv.org/content/10.110…

There is an opening for a postdoc in my lab at UT Austin to work in the areas of statistical genetics and mental health and/or cognitive aging. Funding is in place. Our recent work can be found at lifespanlab.com. Please feel to email me directly. tuckerdrob@utexas.edu