Sabitlenmiş Tweet
Wei Zhou
120 posts
Wei Zhou
@weizhouw
I develop and apply statistical and computational tools to study genetics of human diseases and traits using biobanks. Assistant Investigator @CGM_MGH
Katılım Ekim 2014
234 Takip Edilen908 Takipçiler
Amazing collaborative efforts led by @madduri and Alexis Rodriguez. Applied to run phenome-wide GWASs in MVP, SAIGE-GPU demonstrates a critical framework for leveraging GPU resources to boost the computational efficiency of mixed model approaches in large-scale genetic studies.
Ravi Madduri@madduri
Preprint from the @DeptVetAffairs collaboration with @doescience. Using supercomputers and GPUs from @ORNLComputing to accelerate analyses for biobanks with data from the Million Veteran Program @VAResearch. Joint work with @_anuragverma @weizhouw @JennyGenetics et al.
English
@ZhiYu_ACGT @MGHMedicine @harvardmed Big congratulations, Zhi!! So glad that you decide to stay in Boston🥳🥳
English
@madduri Tutorials to run SAIGE-GPU: exascale-genomics.github.io/SAIGE-GPU/#/ Docker and singularity containers for deployment on various cloud infrastructures are available.
English
A shout out to our amazing team and collaborators, with special thanks to my co-developer @AnnaSECuomo! It’s been such a great pleasure working together! @masakanai @anglixue @TheXavierLab @dgmacarthur @drjosephpowell @dalygene @bmneale We invite your thoughts and feedback! (9/9)
English
With 100 CPUs, it takes < 2 days to map cis-eQTLs for 20k genes across 14 cell types. Trans-eQTL tests have much lower overhead for reading genotypes. Testing 5.3m variants for 20k genes in 3 cell types with 3625, 82,068, and 463,528 cells costs 7, 19, and 26 hrs (8/9)
English
Wei Zhou retweetledi
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ???
I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Yuyang Chen@quenchentin
Thrilled to share our latest discovery on a spliceosomal snRNA gene causing neurodevelopmental disorders: medrxiv.org/content/10.110… Thank you to everyone who contributed; it’s been a phenomenal effort to collaborate with clinicians and researchers for what would help many families!
English
A bit belated, but I am thrilled to receive the notice of award for my lab's first R01 from the @genome_gov!!
I'm extremely thankful for their early career support, and for the many mentors, co-Is, letter writers, and team members who contributed. Excited to get into the work!
English
Wei Zhou retweetledi
Excited to share our work in print at @AJHGNews using variant call data to estimate DNA contamination. As our sample sizes get into the millions of genomes, we need methods like this to efficiently process and quality control the data authors.elsevier.com/a/1i8PAgeX6LB%…
English