Warren Togami

Long COVID Status Update 2025 Dec 22 Symptoms Summary * Severe since 2022: Brain fog, PEM, PENE. During 2022 I was bedridden for 6 months. I could barely walk down a flight of stairs, felt unsteady and unbalanced. Could not read or copy a 7 digit phone number. Brain was severely malfunctioning to the point where I struggled to form sentences. Driving was dangerous. * Some improvement 2024: Feel chronically ill. Thinking is difficult. Brain fog in and out. Physical exertion is punished. For example assembling this IKEA furniture took me ~2 days of effort followed by 3 days of PEM crash. * POTS: Maybe moderate? I am not terrible most of the time but briefly exerting at odd angles like to pick up kids makes me dizzy. Full on tilt table test makes me feel VERY BAD for 2-3 days. * MCAS? Not sure. Many of my symptoms get worse if I stop my antihistamine medications. Hydroxyzine seemed to be the most effective but I had to stop it recently due to drug interactions. Currently on the much weaker loratadine. * Chronic prostatitis. Started at the same time as LC back in 2022. Crippling pain. Inflammatory something caused tissue to obstruct leading to BPH. * Complex autoimmune changes 2022-2023: CCP IgG positive suggests RA. I received some symptom mitigation from hydroxychloroquine. By 2025 CCP IgG disappeared but I became ANA positive instead. Treatments that didn't work - LDN, long duration Paxlovid, Adderall, Metformin (drug interaction) - rapamycin - sort of works but causes problems over time. This again feels like a clue mitigating downstream problems not the upstream cause. - splenic nerve stimulation - This was an interesting failure! It caused a WONDERFUL FEELING OF TOTAL RELAXATION as the brain-on-fire went away entirely. For 18 hours I felt great. That was followed by symptoms coming back ... then slowly I felt sicker and sicker. It is known to reduce cytokines. I think it causes temporary immune compromise allowing for viral activation. Two weeks later I was symptomatic and tested positive for COVID on a home antigen test. That was an interesting and spectacular failure. I intend to try it again in combination with the combination treatments described below. Treatments - November 2023: hydrogen inhalation mitigates my brain-on-fire symptoms every time. Hypothesis: cancels out reactive oxygen in all cells in your body, temporarily mitigates problems with damaged mitochondria. This is definitely a downstream mitigation but not addressing the upstream cause. Unfortunately the effects wear off after only a few minutes. It isn't a solution, more of a clue, but it is at least something I can use to cope during a heavy PEM crash. I should write a thread exclusively on the topic of hydrogen inhalation for LC/ME. - December 2024 azithromycin caused significant symptom improvement for 1 month. Temporary improvement to brain fog and PEM, and temporary near remission of prostate pain. The effect stopped working so I discontinued. I have to wonder if long-term antibiotics might have been the cause of autoimmune biomarkers changing over time. - July 17th 2025: 1st Pemgarda. See my other thread. x.com/wtogami/status… - October 3rd: brain fog was very bad. Two days after Novavax brain fog improved a lot and stayed that way for two weeks. Unfortunately it feels like brain fog might be a separate thing from cognitive dysfunction. Exertion still caused neuro crash and inability to think. - October 22nd: Started val/cel combo. Val alone seemed to improve my PEM baseline 30%. Cel seems to be reducing inflammation a minor amount. Honestly not sure what cel is doing but sticking to it because of the Pridgen Protocol. GP is concerned about the long-term GI risks of that high cel dose. I didn't randomly decide to try val/cel. My labs this year on multiple occasions have read high EBV IgM which suggests dormant viral reactivation. Valacyclovir is not targeted at EBV. My guess is multiple other dormant Herpes-family viruses are reactivated at the same time. ID doctor wanted me initially to try valganciclovir which is targeted against CMV. I decided to try valacyclovir first because of excellent safety profile (no black box warning). Whatever val is doing seems to be suppressing a major portion of a persistent infection. I still feel constantly ill. Ability to think has improved by 30% on a sustained basis which is a lot better than past years. That might be due an improved my PEM baseline. I'm not sure. I tried to play catch up with years of defferred maintenance, overdid it and caused a neuro crash for a few days. December 4th: azithromycin again mitigated both neuro and prostate symptoms. - Very Soon: 2nd Pemgarda The Pridgen Protocol trial suggested better results for those who took combination Paxlovid during a portion of the long duration val/cel. In my case I'm combining long duration val/cel with Pemgarda and Paxlovid. x.com/wtogami/status… My previous Pemgarda didn't yield lasting improvement. I had some serious problems like heavy drug interactions with the combination antiviral. This time I eliminated all meds that conflict with Paxlovid. I'm refusing the pre-medications that interfere with my ability to feel what effect if any Pemgarda is doing to me. - Biomarker Monitoring I'm periodically getting freezing blood/serum/plasma vials before each big treatment. If a big change happens after a treatment then analyzing before and after vials may help to figure out what changed. Future Stuff I want to try 1) Microdosing GLP-1. No reason not to try this. I previously could not try because it had a dangerous interaction with those same meds that I can't take with Paxlovid. But after elimination I can try both this or the milder Metformin again. 2) I'm interested in antiretrovirals where some people had success like with Maraviroc. 3) I am intrigued by the anecdotes coming from the Anktiva LC trial. I have now begun monitoring biomarkers to help determine if I am a good candidate for these immune modulating treatments.

We need Ukraine's drones. At least these Gulf countries are buying them.

He should be getting help from Ukraine because their drones are state-of-the-art and specifically designed to defend against those of Iran. Congress should sign a Ukraine drones bill today.

@hempster4twenty The vast majority of Android devices either don't allow installing another OS or cripple functionality if you do. GrapheneOS has an official long term partnership with Motorola. We plan to support multiple of their new devices each year starting in 2027: x.com/GrapheneOS/sta…

After SARS-CoV-2 infection, the risk of later EBV mononucleosis was higher than in people without recorded COVID-19. A study based on nationwide Swedish registries followed nearly 10 million people🧵

@bullishbruk @ImmunityBio This treatment hurts like hell. Are we talking about microdosing or something?

$IBRX BREAKING NEWS! Anktiva Breakthrough: IL-15 Superagonist Reverses Age-Related ALC Decline, Restoring Youthful Levels in NCI Data — 138-Patient Trial Sparks Hope for Healthy Aging & Cancer Prevention. Even when we say @ImmunityBio is a $1T MC company in the making, we say it with confidence! @DrPatrick @Umbisam @alc2022 @LoriMills4CA42

Incredible how everyone on earth now knows that Trump works for Putin except the American voter.

@Elijahkrings Which lab? Are you able to self order this with cash?

Just found out that lymphocyte subpopulation panel costs roughly 150$ This could be one of the best blood tests to use to modulate the immune system to your specific case In a world where theres fucked up lymphocyte counts & profiles, we can gauge the current state and use precision peptides, nutrients & phytochemicals Why I am interested in this especially is as I am a T1D case, where normally you'd see elevated Th1 response, but symptoms of mine rather classify as Th2

Don Bacon on Russia-Ukraine: We shouldn't act like a referee in a boxing match between two equals. No, we have a victim, a democracy being invaded, and a dictator doing the invading. We should not act neutral. This is good versus evil. I expect more from a Republican administration: stand up to the bully, stand up to Putin. I'm a Reagan Republican. I support negotiations, but there's right and wrong here, and we’re acting morally blind.

Trump is, again, lying about shortages of ammunition for the war against Iran due to some imaginary supplies to Ukraine. Here are some facts: The kinds of weapons we are using to strike Iran were NEVER sent to Ukraine: PrSM (entered service in 2024), LUCAS drones (brand new), Tomahawks (Trump talked about sending some, never did), and of course B-2 Spirit stealth bombers, F-22 Raptors, and F-35s -- obviously none were ever transferred to Ukraine. The only weapons one might plausibly refer to would be ATACMS: the entire stock we deigned to send Ukraine was about 50 rounds (we had used 800 in the opening days of the Iraq invasion). The US used over 20 weapons systems to hit over 1,000 targets simultaneously during the opening hours of Operation Epic Fury. An estimated 300 Tomahawks were used and the Pentagon ordered... 57 new ones in the current fiscal year. There have been no deliveries of THAAD interceptors since 2023 and no new orders were placed this year. The military will get 39 in 2027, six years after ordering them. If we are running short on ammunition, it's because the people ordering this war did not plan adequately for contingencies and spent like drunken sailors, not because of our (really nonexistent for the past year) aid to Ukraine. Our big problem is that right now, we are still using extremely expensive systems like Patriots ($3-4 million per missile) and NASAMS/AMRAAM interceptors ($0.8-1.2 million per missile) to combat mass-produced $20,000 Shahed drones. This asymmetric exchange ratio between offense and defense is what kept analysts at night during the Cold War and why eventually defense systems would be scrapped for being too easily overwhelmed by numbers despite being technologically superior. Ukraine has been fighting and innovating precisely to deal with the asymmetric offense capabilities of Russia for years, and they have learned how to do it. But when they offered to help us last year, the Trump administration arrogantly brushed them aside. Now we are squandering premier weapons designed to stop ballistic missiles on cheap drones. And we can't keep doing it no matter how wealthy we are. Missiles take months, sometimes years, to make, while drones can be mass produced in weeks. You lose wars not when the offense peaks --- as the current bombing afficionados at the White House have you believe with their nonstop meming about raining destruction on Iran -- but when your defense capacity is stretched to its limits and cannot cope with things that keep coming at it.

For many people, COVID did not end when the infection cleared - it evolved into a longer and far more complicated story. This paper presents Long COVID as a heterogeneous, multisystem condition that can affect nearly every organ system🧵

@MishaalRahman @AkiraJkr1 @worldno1goodboy IMO this makes it not so bad.

@AkiraJkr1 @worldno1goodboy One time thing - it's my understanding that, if you wish, you can disable developer options after enabling the advanced flow. Doing so won't disable the advanced flow.

📢 Important update on sideloading on Android It’s of course here to stay. The team’s been listening carefully to feedback from power users who want a way (apart from ADB) to install apps that don’t go through developer verification. Today, we have more details on the advanced flow that gives you this option. Read the post👇 for more info goo.gle/advance-flow

hi i’m a disgraced former cryptocurrency CEO who siphoned at least $8 billion in customer deposits to my girlfriend via a hidden backdoor in FTX’s code so she could gamble it all away on losing trades, cover our asses, fund my lavish lifestyle, and bankroll hundreds of millions in political donations while we lied through our teeth to customers, investors, and lenders that the funds were safe and segregated, for which i was subsequently convicted by a federal jury on 2 counts of wire fraud, 2 counts of conspiracy to commit wire fraud, 1 count of conspiracy to commit securities fraud, 1 count of conspiracy to commit commodities fraud, and 1 count of conspiracy to commit money laundering. here are my thoughts on the Iran war:

@MCFCDamo @LundukeJournal The UK absolutely has the right to block anything they want. They do not have the right to force an American company to do the job for them.

@LundukeJournal Saying "you don't have jurisdiction but we operate in your country" is a very fun thing from a meme lawyer. Let's see how this plays out. (It ends with a country wide ban for 4chan FYI)

The United Kingdom has demanded that 4chan pay a £520,000 fine for failure to comply with UK age verification laws. However, since 4chan is based in the USA, the UK has no jurisdiction to fine Americans in America. “As has been explained to your agency, ad nauseam, the United Kingdom lost the American Revolutionary War. We are not in the mood to discuss the matter further, and have not been in the mood for 250 years.” The letter to the UK’s Ofcom ended by suggesting that “maybe, you could just stop sending Americans stupid letters and acknowledge the sovereignty of the United States.” 4chan’s attorney, @prestonjbyrne also included a picture of a giant hamster dressed as Godzilla.

@zalaly @BMJMedicine What would have happened to these patients without GLP-1 to begin with?

What happens to the heart when people stop GLP-1 drugs? The short answer: nothing good. New from our team: a study of 330,000+ people in @BMJMedicine 🧵

@tiredguineapig Curious how do you know you are dealing with persistent viral antigen? Other labs? My results are high on #1 Antiviral Response. In my case I have confirmed EBV persistence from other labs, and rapid response to Pemgarda which suggests persistent COVID.

Why Bitcoin mining does not compete with other users for power The more you study Bitcoin mining, the more you realize how important it is to energy stability, energy equity, and global sustainable development goals. Bitcoin mining does not compete with other users of energy for power for a very simple economic reason: the inbuilt economic incentive mechanism disincentivizes Bitcoin mining companies for using power when wholesale electricity prices spike (ie: there is high contention for that power). That is why former ERCOT Grid operator Brad Jones called Bitcoin mining a “non-rival energy user”. It powers down when the price of power becomes too expensive; the very time other people want/need that power. Source: youtube.com/watch?v=gKnRfD… There is a large body of data that demonstrates Bitcoin mining operations behaving this way and helping to stabilize the grid at times of peak power demand, well documented in the media. (see below). What the evidence does point to is that more people have access to energy who otherwise would not have as a result of Bitcoin mining. For example, Gridless in Africa has delivered renewable energy to four villages. This has already brought an estimated 28,000 people out of energy poverty. Meanwhile, on a bigger scale in Ethiopia, in the last year Bitcoin mining generated $220Million for EEP (Ethiopia's state owned electricity company) from surplus renewable hydro-energy. Source: capitalethiopia.com/2025/09/21/bit… EEP's plan is to use that additional revenue "to go towards funding the expansion of the grid" (to rural areas currently without electricity source: youtube.com/watch?v=mqie7b… Here's some recent media reports on Bitcoin mining behaving as a non-rival customer and helping stabilize the ERCOT (Texas) grid during extreme weather events (via voluntary curtailment/demand response): “Winter storm descends on Texas, bitcoin miners shut off to protect ERCOT” CNBC, February 3, 2022 cnbc.com/2022/02/03/win… “Limiting crypto helped the Texas power grid weather a heat wave” Texas Tribune, July 15, 2022 texastribune.org/2022/07/15/cry… “Texas Data Centers, Crypto Miners Reduced Power Use During Storm” Bloomberg, January 29, 2026 bloomberg.com/news/articles/… “Can the fragile Texas power grid handle a cryptomining gold rush?” (explicitly notes miners can help stabilize the grid during high-demand periods) NBC News, July 22, 2022 nbcnews.com/tech/crypto/ca… “Bitcoin Miners Power Down US Operations in Wake of Winter Storm” Bloomberg, January 26, 2026 bloomberg.com/news/articles/…

I am a Democrat. I served in the Clinton administration. I did not vote for Donald Trump and am highly unlikely to support him or his acolytes in the future. I also have serious disagreements with many of the Trump administration’s domestic and foreign policies. But it is profoundly disturbing that a growing segment of the far left appears to be almost rooting for Hamas, Hezbollah, the Iranian regime, and other forces fundamentally opposed to the United States and our allies. This seems to reflects a corrosive strain of anti-Americanism, dressed up in postcolonial theory, that risks blinding us to the moral realities of our world and the nature of our adversaries.

@dmonnin1 @shanaka86 Did you read the OP? The fertilizer that we import is suddenly way more expensive. So we're already screwed.

@wtogami @shanaka86 Great idea. Right in the middle of a worldwide oil shortage. Let’s increase our oil based fuel use.

Right now, in barns and equipment sheds across the American Midwest, farmers are making the most consequential decision of this war. Not generals. Not senators. Farmers. At $683 per ton urea, corn economics have collapsed. Nitrogen is the single largest input cost for corn production. At pre-war prices a farmer could justify 180 pounds per acre and expect a margin. At $683 the math breaks. Soybeans fix their own nitrogen from the atmosphere through root bacteria. They do not need the molecule trapped behind the Strait of Hormuz. The seed decision is being made this week across roughly 90 million acres of American cropland. Once the planter rolls into the field, the choice is irreversible. Corn seed in the ground stays corn. Soy seed stays soy. The acreage allocation locks in. USDA Prospective Plantings reports March 31. That report will tell the world how American agriculture responded to the Hormuz blockade. But the decisions it captures are being made now, in conversations between farmers and agronomists and seed dealers who are looking at nitrogen prices and making the rational economic choice: plant the crop that does not need the input you cannot afford. Every acre that shifts from corn to soybeans tightens the corn balance sheet for the rest of the year. Corn feeds livestock. Corn feeds ethanol. The Renewable Fuel Standard mandates 15 billion gallons of corn ethanol annually, consuming roughly 43 percent of the US corn crop regardless of price. That demand is inelastic. If acres shift and production falls while the mandate holds, corn prices spike. Feed costs spike. The protein cascade reverses. The US cattle herd sits at 86.2 million head, a 75-year low. Poultry and pork margins that were benefiting from cheap feed compress when corn crosses $5 per bushel. This is how a naval blockade 7,000 miles from Iowa reaches the American grocery shelf. Not through oil. Not through shipping. Through nitrogen. The farmer cannot afford the molecule. The molecule cannot transit the strait. The farmer plants soy instead. The corn supply tightens. The ethanol mandate consumes its fixed share. The remaining corn reprices. The feed reprices. The meat reprices. The grocery bill reprices. The decision is not political. It is arithmetic performed on a kitchen table by a person who needs to plant in three weeks and cannot wait for a ceasefire, an escort convoy, or an insurance normalisation that the Red Sea precedent says takes years. The deepest penetrator in the American arsenal cannot reach a sealed Iranian doctrinal packet. But the fertiliser price it failed to resolve is reaching every planting decision on 90 million acres of the most productive farmland on Earth. The war’s most irreversible consequence is not happening in a bunker. It is happening in a barn. And by the time USDA publishes the data on March 31, the seeds will already be in the ground. Full analysis in the link. open.substack.com/pub/shanakaans…

@screwtwatters @MalcolmNance @ratlpolicy @Schizointel People who know what they are doing are a threat.

@MalcolmNance @ratlpolicy @Schizointel Only by the multitude of fired personal, on multitude levels, that has been fired would have change something in the decision making… but I think they would have been ignored anyway🤷‍♀️

This is yet another overhyped & misleading talking point. The minesweepers were 30+ years old, relied on sending sailors into harm's way, & were due for normal decommissioning. That decision was made by the Biden administration in 2024. The LCS minesweeping package is a replacement for that capability - yet unproven, but modernized & safer for American sailors. Also, Iran's ability to mine the Strait is being degraded hourly. This claim is meant entirely to craft a narrative of poor planning & inevitable failure, but this narrative is detached from observable reality.

@kbuck811 @rorynotsorry What was the clinical trial starting dose before titrating up?

I was in the clinical trial for 2 years for retatrutide. I was slowly titrated to 9 and stalled after 18 mos then went to 12 and lost another 30 lbs in last 4 months of trial. Total weight loss 110 lbs. it’s a miracle drug. I am on tirzepitide 15mg now to try and maintain overall loss but have gained 15 lbs in the last 6 months. There is a stark difference between both drugs.

If you have used Retatrutide to lose a decent amount of weight (20lbs or more) What is or was the optimum weekly mg that you have found effective.