Yan Xiang

My review article on Monkeypox Virus biology including its host range and evolution potential: Monkeypox Virus Emerges from The Shadow of Its More Infamous Cousin: Family Biology Matters tandfonline.com/doi/full/10.10… My lab is also looking for postdocs to work on SARS-CoV-2.

Another preprint is out. This one with @xiangylab. We describe a new, sensitive assay for the CoV exonuclease. Recovery of proofreading-impaired virus variants reveals an exonuclease activity threshold for viability. biorxiv.org/content/10.648…

Structural Mechanisms of SAMD9 Autoinhibition and Pathogenic Dysregulation biorxiv.org/content/10.648… Three years of collaboration with the Dai lab (@DaiLab_CWRU) —great science, great teamwork, and a lot of fun along the way.

Structural Mechanisms of SAMD9 Autoinhibition and Pathogenic Dysregulation biorxiv.org/content/10.648…

Gratitude to #TWIV @RichCondit @profvrr @BioProfBarker for their insightful discussion on our recent paper, uncovering the role of SAMD9 and SAMD9L as virus-activatable tRNA nucleases. The discussion starts from ~ 29 minutes to 1 hour 24 minutes mark. youtu.be/n7Gf1cihmpI

@xiangylab findings on SAMD9 is the possible ribotoxic stressor we missed out @ebennettlab @Daugherty_Lab Now this suggests that VACV lacking K1 and C7 will be even more dependent on ZNF598 for proliferation. Beautiful work ... Please read here science.org/doi/full/10.11…

@CameronLabUNC Don’t like your vegetables?😀

Takeout tonight. So dangerous (and expensive) having this place in walking distance from our home. 😬 But so, so, so good. 😋

Transformative work by ⁦@xiangylab⁩ showing that the restriction factor, SAMD9, incapacitates protein production in infected cells by cleaving in the anticodon loop of a tRNA. science.org/doi/10.1126/sc…

Fauci on Monkeypox: What Went Wrong gimletmedia.com/shows/science-…

Monkeypox has been spreading around the world. So … what exactly is this disease? How worried should we be, and how can people stay safe? This episode of SCIENCE VS provides insight from Dr. Carlton Thomas, Professor Chloe Orkin and Professor Yan Xiang. podcasts.apple.com/us/podcast/mon…

I am grateful to @NWO_Science for funding our XL application to discover the Achilles' heel of #CoV. Exciting projects focus on deciphering CoV RNA synthesis and packaging using virology, experimental and theoretical biophysics! Positions soon to come! nwo.nl/en/news/twenty…

"Un ejemplo extremo (de la estabilidad de los ortopoxvirus) es el aislamiento del virus infeccioso de las costras de la viruela (humana) después de 13 años de almacenamiento a temperatura ambiente" tandfonline.com/doi/full/10.10…

Monkeypox virus emerges from shadow of its more infamous cousin:family biology matters:(MPXV)member of Orthopoxvirus (OPXV) genus of Poxviridae family;Poxviruses are large, enveloped virus,genome is linear,(dsDNA)of ∼200 kb pairs,closely pack∼200 genes. tandfonline.com/doi/full/10.10…

Breaking News: The WHO has declared monkeypox to be a global health emergency. With cases already in dozens of countries, many experts had urged faster action. nyti.ms/3PI8CZC

Governments and funders must prioritize research on emerging and re-emerging infectious diseases such as monkeypox to prevent another pandemic. nature.com/articles/s4159…

3/ “Considering that IgA neutralises the virus at the mucosal level, this suggests that respiratory transmission may have played a role.” “The virus was well detectable in the upper airway and intact peri-anal skin, without any visible pox lesions at these regions”

Happy hour with my fellow DNA virologists and Texans at #ASV2022

So happy to hang out with my scientific brother @CameronLabUNC #ASV2022

So proud of my student, Marisol Morales, who gave a wonderful talk on antiviral factors and tumor suppressors SAMD9 and SAMD9L at #ASV2022

The Department of Microbiology, Immunology & Molecular Genetics at the University of Texas Health San Antonio is seeking a virologist to fill an open-rank faculty position. m.rfer.us/UTHSCSAEV35Eo

1/Monkeypox is a member of the Poxviridae family. These are large viruses with large DNA genomes (∼200 thousand bases🧬). By comparison, sars-cov-2 has ~30 thousand. And since its genome is made of RNA it mutates more than monkeypox. Nice review article:rb.gy/higk98🧵