Wen Xue

📰 Hot off the press from the Xue & Sontheimer labs: Prime assembly enables precise genomic insertions up to 11 kb in cells, providing a universal strategy to correct many pathogenic mutations within a gene. Read it here @Nature: buff.ly/dYn0NjS @xue_lab @UMassChan

Prime assembly with linear DNA donors enables large genomic insertions biorxiv.org/content/10.110… #biorxiv_biochem

The reverse transcriptase domain of prime editors contributes to DNA repair in mammalian cells go.nature.com/3X6mOBv

The RTI & @UMassChan Medical School seeks the next generation of scientific leaders! Join our research community as a Maraganore Early Independence Fellow. Get 3-5 years of support. Apply by Dec 1 to join us: academicjobsonline.org/ajo/jobs/28425

This paper has moved on to Round 3 of the bracket-style competition STAT Madness, assembled by STAT News. Voting closes on Thursday, March 21, at 11:59 p.m. Click on the UMass Chan logo to vote. statnews.com/feature/stat-m…

The Anderson lab and @xue_lab identified an ideal lipid nanoparticle to deliver mRNA and CRISPR components into lung tissue. Published in Nature Biotechnology, the research demonstrated that we could effectively edit genes in the lung airway epithelial cells.

The @xue_lab's paper is the last one standing from UMass, so please help our colleagues continue on to the Elite Eight by voting again; five days left of voting! Click on the link below, sign in, look for UMass Chan icons, and VOTE! statnews.com/feature/stat-m…

Lowe Lab (2005-2015)

I am honored to attend the Lowe lab 25 years reunion. Lots of great memories. Thank you, Scott!

Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates go.nature.com/48hmu76

T-10 days to the '25 Years of Lowe Lab' Reunion! Looking forward to welcoming back 80+ alumni for two days of science, memories, and catching up. Will continue to highlight lab alums over the coming days. #LoweLab25

Lars was also a great co-mentor to students. He and Wen Xue teamed up on some of the most important papers from the lab. Wen now has his own lab focusing on genome editing @UMassChan – check it out @xue_lab! -SWL #LoweLab25

Congrats to Wen Xue, PhD, Scot Wolfe, PhD, and Erik Sontheimer, PhD, for receiving a new @theNCI grant to use in vivo prime editing for #precision #cancer models. @xue_lab @ESontheimer_lab @ScotWolfe1 @UmassChan @RTI_UMassChan

@kochinstitute @MITChemE @UofTPharmacy @RTI_UMassChan @UMassChan @BostonChildrens @MIT_IMES @RareDiseaseCure @xue_lab @BowenLi_Lab New nanoparticles can perform gene editing in the lungs #NBTintheNews via @MIT news.mit.edu/2023/new-nanop…

Join #SCGE investigator Shunqing Liang, PhD at #ASGCT23 for a presentation on "Develop combinatorial non-viral and viral CRISPR delivery for lung diseases." 📍: SCGE Scientific Symposium 🗓️: May 19 ⏰: 11:00 AM Symposium agenda: annualmeeting.asgct.org/program/agenda…

And read the Research Briefing here: nature.com/articles/s4159…

PE-Tag developed by Scot Wolfe and team @UMassMedical is an efficient genome-wide approach to map off-target effects of in vitro and in vivo genome editing. nature.com/articles/s4159…

#SCGE PIs Daniel Anderson of @MIT and Guangping Gao and @xue_lab of @UMassChan designed a new nanoparticle for highly efficient RNA delivery to the lungs. Read more ⬇️ #nanoparticles #RNAdelivery #geneediting #therapeutics

Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing go.nature.com/3KlMaFA

#PublicationFriday📚 In this recent paper, #SCGE PIs @ESontheimerLab and @xue_lab use multiomics to identify elements of hepatoblastoma, a rare tumor of the liver pubmed.ncbi.nlm.nih.gov/35932276/