A. Hoss.

@bneyshabur @MirendilAI @a16z @kleinerperkins 👏🏻

Today, I’m excited to formally announce @MirendilAI with my amazing co-founders Harsh Mehta, Shayan Salehian, and Tara Rezaei! We’re fortunate to work with @a16z and @kleinerperkins, who led our seed round of $200M, followed by a major investment from NVIDIA, among others. Mirendil exists to accelerate science and technology, and through them, to help solve humanity's most pressing problems. Self-accelerating AI R&D is the most direct path to delivering on AI's broader promise, which is why we believe the most important application of AI is AI itself. Get this loop right, and it compounds. It fundamentally changes the rate of progress itself across all domains. We believe this capability should be democratized. It should be used to power all scientific efforts trying to innovate at the frontier. There are far more important problems—and broader ones—than any single lab can take on, so more groups should be able to pursue them. This pulls concentration of power away from a few labs: businesses and science labs can own their AI and infrastructure, keep their margins, and control their own destiny instead of ceding it all to a single AI lab. We’re a small team with a singular focus. Our founding team consists of 20 researchers and engineers from frontier institutions including Anthropic, xAI, Google DeepMind, and OpenAI, united by a passion for science and a drive to build the technologies that move it faster. If you want to build the system that builds systems, join us! @HarshMeh1a, @shayan_, @tararezaeikh

@jeffzwang well well, this is the one I was asking you about on Salesforce Tower entrance… great!

Exa Connect enables LLMs to see the world beyond the public web: financial data, podcasts, private news, papers, a lot more This was surprisingly hard to build - frontier LLMs with popular harnesses can oneshot video games easy peasy, but in my experience complex context gathering is actually still bad (or expensive). This makes it way easier 🫡

@0xsamgreen elegant

Do you want to see into the future? In 1996, Charlie Munger gave a brilliant talk, "Practical Thought about Practical Thought: Turning $2 Million Into $2 Trillion," where he imagines a founder in 1884 who wants to take a startup called Coca-Cola from $2M and pre-product to $2T in 150 years. To do this, he assumes the world's future state, like the population and how much water people drink, and works backward through time, considering the major decisions and milestones required to turn $2M into $2T by selling carbonated sugar water. The result is a strategic path. He calls this technique "inversion" and credits mathematician Joseph-Louis Lagrange as his inspiration. Inversion is the core of AI (backpropagation and RL), and LLMs can do it well. Here's something to try. Ask GPT-5.5 Pro Extended (or Anthropic's top model) to read Charlie's Practical Thoughts talk, then tell the model your ambitious long-term goal in detail (e.g., for your company, career, finances, health), and ask it to use the inversion approach to create a plan and identify potential pitfalls. I think you'll be interested in what it has to say.

“There's also a crypto provision tucked into the legislation. It forbids the federal government from issuing a digital dollar “ axios.com/2026/06/23/hou…

@insider0x beautiful brilliant idea - thank you

How much of Anthropic revenue is CCP distillation budget

when interest rates go up, the value of future time declines. as the future becomes worth less economically, human time horizons contract, regardless of wealth. now if the volatility also goes up, your temporal value, also collapses your value might be equal to just one viral post. one little “high theta”, 0dte just abt to expire.

vibe code your pet

@Alfred_Lin amen padre 🙏🏻

if the ai native healthcare in fact works, the life span is expected to increase. who benefits / who loses? - life insurance companies will be happy i believe. they gotta payout later. - pension funds (if any left) - most likely the human i guess if human (subject/customer) has terminal value of life insurance - estate well, lend against that exit. think of reverse mortgage.

@PersianQuant how so?

i dropped out of high school to work on ai diagnosis at a neuroscience/vision lab small(er) tienlan would've been happy to see that i'm still working on this finally sharing a coherent piece on foresight health's ambitions to help solve care for chronic diseases with ai

@tienlan_sun you need a swap market i think

@tienlan_sun life insurance vs health insurance

@rememberlenny organization is not an issue in many places that seem slow

At 36, I'm thinking about my next career steps. Over the years I founded a company, helped scale ChatGPT, and spent time in venture. I'm grateful for all of it. I wrote about the path, and the idea I want to spend the next ten years working on.

moneyness increases… interesting do you have data on getting divorce? like i can’t wrap my head around the cost of divorce controlled for or not. women moneyness increases and men don’t change => makes divorce less costly for women. (expected). so, if the GLP1 increases divorce rate… then?

GLP1s for weight loss impact lives beyond health. My new paper shows single women’s marriage/cohabitation rates rise 29pp, employment among nonemployed women rises 27 percentage points after 1.5+ years. Link to paper below:

@venturetwins just fired our korean designer just to be sure lol

Found this Korean guy using AI video to make ads for products that should exist. No idea what he’s saying, but I’m a fan 😅 (this is 404product on IG)

@bossriceshark my mom: if you don’t talk they won’t assume you are deaf. don’t worry. lol

My mother always told me: If you don't have anything nice to say, don't talk

grew up watching opec meetings. members joined and left. endless quota cheating. that is how i first learned game theory, now reading this article, feels like pure reminiscence of my younger self. except now the strategic resource is frontier models, treated as the new oil. if game theory principles hold, the coming price wars and defections will be instructive to watch. and a clean setup to generate alpha from the inevitable fractures or one might say, open source will undercut them which i doubt. axios.com/2026/06/20/ai-… #ai #opec #g7

i think performance bonds are better fit for ai agents vs insurance. that type of risk is not diversifiable…

@barrowjoseph @DenisPeskoff holly shit!

New paper: every law in America is technically public. But not really, until now! With @DenisPeskoff at UC Berkeley, we built a corpus of ~every publicly accessibly city and county law, and released a huge chunk of it! 2.2 million laws, you're (probably) covered in it! 🧵

@nicochristie on edge! bravo!

Shortcut can now spin up 1000's of agents to parallel search, but we built the feature entirely around the filesystem - enabling some pretty cool new things Here I fill out a huge table of VCs we tracked for a fundraise and another table that has subtables, merged cells, etc.

there is a theme now anti ai slop either code, taste, precision… the second order waves…