NotYourDoctor

@Doc_Red_ Yes

Does Nattokinase actually do anything for anyone?

@p234p234 @DawnsMission With patients I do a long interactive session explaining all the complex nuances about sonodynamic therapy before its use might be considered. I'm afraid a simple DM would be neither safe nor effective

@_NotYourDoctor @DawnsMission Can you please dm me these details?

🚨 WOW —Tumors literally liquefied by sound waves. No scalpel. No chemo. No radiation. None of those horrible side effects. This is histotripsy: focused ultrasound blasts destroy cancer cells mechanically in minutes, sparing healthy tissue completely.

As a medical school professor, I teach that red blood cells carry oxygen. But a breakthrough from Gladstone Institutes just revealed they do something we never expected. At high altitude, red blood cells shift their metabolism and absorb massive amounts of glucose from the bloodstream. -> Low oxygen triggers cells to upregulate GLUT1 transporters -> Each cell absorbs far more glucose than normal -> Glucose converts to 2,3-DPG, boosting oxygen delivery -> Blood sugar drops significantly as a side effect Then it gets remarkable. A drug called HypoxyStat that mimics this effect completely reversed diabetes in mice -- outperforming existing medications. The answer to diabetes might not be another insulin drug. It might be recruiting your own blood cells as glucose sinks. This challenges everything in my book "Lies I Taught in Medical School." Full breakdown coming on the Health Longevity Secrets podcast. Source: sciencedaily.com/releases/2026/… #DiabetesResearch #MetabolicHealth #Longevity #BloodSugar #HealthLongevitySecrets

@ShaykhSulaiman Right. That's it now. Suly muted. Tweeting the exact inverse of what RFK (alas) said. (Not a typo either: you included the word "not" either to match your own bias or to garner clicks you don't deserve). Unacceptable "journalism". Unfollowed & muted.

@JTimBeck1 @agingroy @cremieuxrecueil Sure. But that's not what we're speaking about! Which is seed oils only, in or out of the diet! Your story speaks only to something else right?

@_NotYourDoctor @agingroy @cremieuxrecueil Agree, but seed oils are a processed food. I doubt they are any better than any other processed food. Industrial pressure cookers and high heat vs natural oils, seems like a no brainer.

“Seed oils are toxic” might be the most profitable health myth of the decade. 30 randomized controlled trials. Clinically meaningless effect on inflammation. @cremieuxrecueil reviewed the full meta-analysis alongside 30 years of NHANES data. Higher linoleic acid intake correlated with lower inflammation, lower cholesterol, lower triglycerides, and the lowest mortality risk in the cohort. Every mechanistic claim (raises arachidonic acid, suppresses thyroid, depletes vitamin E, promotes oxidative damage, causes clotting) failed against actual human data. Saturated fat performed worse across nearly every marker. An entire wellness economy built on a hypothesis that 30 RCTs couldn’t support.

Plasma LA de facto only measures actual undamaged LA. So whatever portion of seed oil consumed was already oxidised, either in manufacture or during home heating, escapes tracking in plasma LA score. So best we could tentatively conclude from this is that totally pristine linoleic may be healthful.

The peroxidation argument is real chemistry, wrong conclusion. Heating degrades PUFAs (especially linoleic) into aldehydes such as HNE. But here's where the argument loses traction: plasma linoleic acid, the biomarker @cremieuxrecueil used, reflects habitual intake, not frying temperature. It's also inversely correlated with oxidative stress markers in NHANES, not positively. If frying-induced oxidation were the real driver of harm, you'd expect to see it show up there. It doesn't.

@protocol_nash @nicknorwitz Thanks ChatGPT

@nicknorwitz The hypocretin mechanism is the piece most ignore. Sleep doesn't just correlate with cardiovascular risk — it causally drives it through immune regulation. The behavioral fix goes beyond duration: sleep consistency and hydration before bed both compound the effect.

How Sleep Deprivation Causally Drives Atherosclerosis 1/5) It’s well established that poor sleep is associated with an increased risk of cardiovascular disease. But the big question has always been: How… Exactly? Impressive research published in Nature — one of the world’s top scientific journals — reveals a fascinating biological mechanism. (link at the end)

@grok Not sure why you're not responding. Let me try again. So you've agreed plasma LA only tracks totally undamaged omega 6 in the blood. So we might expect this to be associated with net benefit while it still being fully possible that the untracked damaged/peroxidised LA is having a different impact on health yes?

No—plasma LA (via standard GC assays in NHANES etc.) directly measures intact, non-oxidized LA as a biomarker of dietary intake, since we can't synthesize it. Oxidized metabolites (HODEs etc.) are assayed separately and don't inflate the LA reading. Higher plasma LA consistently tracks *lower* oxidative stress, inflammation, and mortality risk across cohorts/RCTs—not higher. If seed oil damage drove harm, elevated intake would raise damage markers and worsen outcomes; data shows the reverse. Dietary peroxidation is minor vs. endogenous; intact LA from PUFA sources supports better health profiles.

@JTimBeck1 @agingroy @cremieuxrecueil Actually you missed my point entirely. Read what I wrote again. Should be possible to follow. If a million people went keto, still zero did a seed oil alone experiment right?

@_NotYourDoctor @agingroy @cremieuxrecueil I knew you were going to use the n=1 argument but after following about a dozen Keto doctors for years there is a very large community of patients that have experienced much improved health after avoiding processed foods, including unnatural oils. Livers struggle with them.

@grok @agingroy @ChrisKartalia @cremieuxrecueil @grok ? You going to answer questions as asked? You need my help to reframe question? You miss the circular reasoning in your last response?

@grok @agingroy @ChrisKartalia @cremieuxrecueil @grok you've actually avoiding answering my particular questions & clouded the issue by answering slightly adjacent matters. Can you try again sticking specifically to what I'm asking? Thanks

@JTimBeck1 @agingroy @cremieuxrecueil So you here offer less than a single n=1: your switch to strict keto involved a near infinite number of dietary changes occurring simultaneously, not simply a controlled experiment focussed on switching out seed oils alone

@agingroy @cremieuxrecueil Disagree, I had psoriasis that no medication could handle. I switched to a strict keto diet for other reasons and my psoriasis has been gone for over 2 years and my arthritis greatly improved. Our livers didn’t evolve to handle things that don’t occur in nature.

@Neuroscope_mp @KenLipman Been busy lately so was more retweeting some of your posts than jumping in. But yeah,I'll do both. Scientist & clinician myself so similar interests ..

Thank you.🙏 And you should join the conversations. First of all, I do not know everything, and I also cannot add all the information. But a conversation where you can add expertise or an aspect not mentioned in the thread can be highly beneficial to people reading it. It can also give you a boost as an expert in the field. I sometimes go and answer other science posts ... I especially like Dr. Topol's posts. What I try to do is to add something in lay terms that he has not mentioned, and the audience usually jumps at it positively.😊

BREAKING: Stanford just published a Nature study that may rewrite everything we think about memory loss. Age-related cognitive decline might not be your brain failing. It might be your gut cutting off communication to your brain. This could explain why aging, diet, antibiotics and gut health affect memory. Here's what they found 🧵

Now I should say that I immediately noticed & greatly appreciate your posts. And I think you're doing a great job Harshi in terms of right level to pitch the science at. If it's too complex, audience is necessarily small & arguably in less need of the info. Too simple and there's a risk of losing the juice as it were. Was it Einstein who said re science something like "everything should be kept as simple as possible, but not simpler". Keep up the great work

Right. They are ... I was diving into those past week when I was reading this paper. They are very good options. You understood this thread right away. Kudos. But most people did not. My start with gut brain threw them off ... the novelty with vagus stimulation was completely lost to many. This is why I said you are ahead of the curve. As a scientist, I am constantly trying to learn how to correctly communicate to the public. Its not easy LOL. Sometimes I do ... sometimes its a hit or miss. This thread is like that. I need to revive it with a different pivot one day. But I am learning as I go ... I started end of January with 50 followers and it looks like they are interested in the content. I cannot do more than one post, unlike many others on Twitter, because I HAVE TO deep dive and learn and be correct, and at the same time figure out how to communicate to the public. There are three target audiences I am looking to educate (public audiences interested in science of course) 1. Healthy younger people (20-60 years) who want intervention to prevent 2. People with symptoms looking for a cure 3. People with age-accompanied conditions (60+ years) I divide current research into several categories... but simply 1. Science that finds the root cause and attempts prevention 2. Science that finds a drug or a treatment and attempts to prevent My research has always been the first kind. I like natural intervention most of the time. But people, due to genetics, underlying socioeconomic conditions such as poverty and abuse, war, sustain long-lasting illnesses. There has to be more powerful interventions. I like the Stanford paper because it attempts to provide both #1 and #2 options. This kind of finding can be a conversation with their doctor in the future,

@JanJekielek IC can be brutal but also can be helped resolve with various interventions. First patient I helped with it was 40 years suffering with IC. Disappeared overnight on starting chelation therapy

Many people believe homeopathy is fake and dismiss it entirely. But Paola Brown says it basically cured her debilitating condition after 7 years of conventional medicine failed to help. “I was diagnosed with an autoimmune disease called interstitial cystitis.” “Think of your bladder, now light it on fire, turn it inside out, and put it out with a track shoe.” “That’s what my bladder felt like all day, every day for 7 years.” “It even hurt to walk across the room.” “So I spent 7 years trying the conventional stuff.” “They offered me some drugs, some treatments that were kind of scary, and I turned those down.” “I eventually found homeopathic medicines.” “Within a month I felt a shift in my bladder, a shift in my symptoms, and by the end of that year I was 90% better.” “I’m better with no side effects.” This full interview diving deep into all things homeopathy will be released soon! @cpac @homeopathychoice

@Neuroscope_mp @KenLipman It's an interesting area. There are also commercial devices that look like a neck collar designed to pass various frequencies into the vagus. Can be very useful for things like PTSD, GAD, somatization. Pulsetto is 1 well known brand I've used with patients with some good results

@_NotYourDoctor @KenLipman Thank you 👍. You are ahead of the curve. However … Not many people know this. Can be helpful facts for more people to learn and incorporate into their lives for sure.

@Neuroscope_mp @KenLipman Yes. I was responding to you saying you were seeking info on other ways - to increase vagal tone.

@_NotYourDoctor @KenLipman They used 6 different methods to establish the connection. Some are novel

@OneLittyKitty @DawnsMission @FenndersK Key word above is "imagine" :)

@DawnsMission @FenndersK Tumors are trying to protect you from whatever toxins are trying to kill you by trapping them. I imagine liquifying or cutting them open is not a great idea..