halilakin

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halilakin

halilakin

@halilakin

Scientific intelligence @evoscaleai

Присоединился Mayıs 2009
936 Подписки1.4K Подписчики
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Rohil Badkundri
Rohil Badkundri@rohilbadkundri·
We believe that superhuman clinical trial forecasting is the critical bottleneck to curing all diseases. AI may compress a century of biological discovery into a decade, but if we don’t fix the broken clinical trial ecosystem, very few of those discoveries will make it to patients.
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Ross Taylor
Ross Taylor@rosstaylor90·
In 2021/2022 our team was one of maybe <100 people in the world who shipped a state-of-the-art LLM over 100B. Agentic RL is at least an order of magnitude harder. The infra is just brutal. In contrast, the recipe itself is very simple and basically the same between labs (the biggest open secret in RL for LLMs). But executing it well at scale is very difficult. And doing simple things well is really the art of AI progress at the moment. Focusing on this problem has made building a startup (second time) a lot different this time around. I liken it internally to the “Pit” in Dark Knight Rises. Just to get something we are happy with internally with a small team has taken time - more than we would like - and required real persistence and grit to see it through. We are out of the wilderness now, and getting things ready for launch, but the bags under our eyes say three things: infra, infra, infra. And I envy those who have the luxury of thinking about new ideas rather than getting established ones to work well!
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Michelle Lee
Michelle Lee@michellearning·
I’m on TBPN today at 1:30pm PT. Join to witness my transition from long-time listener to first-time caller. We’re talking about robots, AI Science, and cutting through the hype.
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owl
owl@owl_posting·
writing a long article about lab robotics/automation! please message me if you have strong opinions here and would be open to chatting, i would highly appreciate it and will buy you a coffee if we ever see each other irl
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Minqi Jiang
Minqi Jiang@MinqiJiang·
Seems like the Ilya interview revealed a lot about SSI’s technical direction. I really like the approach he hinted at. If I am interpreting it correctly, it’s an area that has been actively explored in academia but not by the large labs at significant scale.
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halilakin
halilakin@halilakin·
@NarenBriar Congrats/tebrikler/piroz be Naren!
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Naren Briar
Naren Briar@NarenBriar·
Ladies and gentlemen, it is an incredible honor to share that I have won my race for Bellevue City Council with 53% of the vote. For the first time in our nation's history, a Kurdish American has been elected to public office, and Bellevue made it happen. Many questioned whether this campaign's success was within the bounds of possibility. The odds, by any measure, were formidable. Yet I have observed that fortune seldom abandons those who possess the resolution to act upon their convictions. Our victory was a narrow, but healthy margin rather than an overwhelming mandate. This does not serve as discouragement, but rather as incitement, as is usual, to attempt something more full and satisfactory. I am now bound by a sacred obligation: to earn the confidence of those who withheld their support, and to justify the faith reposed in me by those who granted it. I am in deep gratitude for the honor you have entrusted to me, and will dedicate the remainder of my days in your service.
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Chubby♨️
Chubby♨️@kimmonismus·
Metas new models now reason over biology, simulating world models. They don't just find correlations—they explain *why* things evolve. Early days, but a key direction for model evolution.
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a16z
a16z@a16z·
Priscilla Chan and Mark Zuckerberg on Curing All Disease We sat down with Dr. Priscilla Chan and Mark Zuckerberg, co-founders of the Chan Zuckerberg Initiative, to discuss their ambitious plan to cure, prevent, and manage all disease by the end of the century. CZI’s Biohub aims to generate vast biological datasets to train new frontier AI models to guide scientists in the lab, creating a feedback loop to accelerate the pace of basic science and take us towards a world without disease. 00:00 Introduction 03:42 Building tools to accelerate scientific discovery 07:03 Biohub = Frontier Biology + Frontier AI 13:32 "Most diseases should be thought of as rare diseases” 15:39 Inspiration: building a periodic table for biology 19:27 Why virtual cells? 21:17 The Biohub master plan 33:36 The importance of interface design in democratizing scientific discovery 35:34 How Biohub encourages cross-functional collaboration 40:38 Looking ahead: the broader impact of AI on biotech @bhorowitz @vintweeta @eriktorenberg
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Deepak Gopinath
Deepak Gopinath@DpacGopinath·
This also means saying goodbye to my wonderful colleagues at Apple Foundation Models -- it was a place of constant learning, collaboration, and growth. Grateful for such a rewarding experience! (2/2)
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Deepak Gopinath
Deepak Gopinath@DpacGopinath·
Life update: I've recently joined @thinkymachines! Excited by the deep focus on multimodality and infrastructure quality, and I'm looking forward to building with this inspiring and driven team!🚀 (1/2)
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swyx 🇬🇧
swyx 🇬🇧@swyx·
honored to host Priscilla and @finkd on LS, I think their first joint pod since Huberman 2023 10 years in and @ChanZuckerberg is both the most well funded nonprofit in human history and dead serious in its mission of providing {data,tools,models} to cure and prevent all diseases by end of the century: - Biohubs have huge pmf (i explain in writeup below) and now CZI is all in on Biohub - acquiring @EvoscaleAI, the frontier bio research lab backed by @natfriedman - 10,000 GPU cluster in 3 years - imaging and cataloging every cell type and releasing for free (billions of them from nm scale up) - releasing 3 new models for simulating virtual cells: VariantFormer, CryoLens, scLDM being close to solving single cells; they are now launching the Virtual Immune System project, a flagship effort to model the immense complexity of The ENTIRE HUMAN IMMUNE SYSTEM. i was very struck by how Priscilla puts it on the pod: if the immune system is working you’re much more likely to be healthy, if it isn’t you’re not. this may cure diseases we don’t even know are directly connected, like Depression (!!) again, was such a rare honor to host this CZI BioHub pod with @FanaHOVA . Enjoy.
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Latent.Space@latentspacepod

Priscilla Chan and Mark Zuckerberg co-founded the Chan Zuckerberg Initiative (CZI) in 2015, committing 99% of their Meta shares to advance science, education, and opportunity. As a pediatrician and CEO of Meta respectively, they've built CZI into one of the most ambitious technology-driven philanthropic organizations with a moonshot goal to help cure, prevent, or manage all diseases by the end of the century. In this episode, we sit down with Priscilla and Mark to unpack how CZI bridges state-of-the-art AI with open biomedical research, their investments in open-source tools like the Human Cell Atlas, their philosophy on building teams across different disciplines, and what they envision the future of healthcare. @czi @swyx @FanaHOVA

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Alex Rives
Alex Rives@alexrives·
Today CZI is announcing an unprecedented new scientific initiative to build the future of AI-powered biology. I am joining CZI to lead this initiative as Head of Science, and the EvolutionaryScale team is joining forces with Biohub. This is the first large scale scientific effort to combine frontier AI and frontier biology. I feel an incredible sense of optimism in this moment. There is a path to build predictive models of life that can fundamentally accelerate science, and unlock a new understanding of disease. biohub.org/blog/frontier-…
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halilakin
halilakin@halilakin·
@tydsh Sorry to hear that Yuandong!
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Yuandong Tian
Yuandong Tian@tydsh·
Several of my team members + myself are impacted by this layoff today. Welcome to connect :)
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Ekin Dogus Cubuk
Ekin Dogus Cubuk@ekindogus·
I am excited to announce what @LiamFedus and I have been working on: @periodiclabs, a world class team of experimentalists, theorists, and LLM experts. Scientific discovery is inherently an out-of-domain task. Experimental iteration is required for significant advances, regardless of the form of intelligence that is modeling the world. We are building experimental labs that will unlock the next frontier for LLM reasoning. Deeply grateful to our advisory board, Prof. Carolyn Bertozzi, Prof. Mercouri Kanatzidis, Prof. Steven Kivelson, Prof. Zhi-Xun Shen, and Prof. Chris Wolverton, for their guidance and support.
William Fedus@LiamFedus

Today, @ekindogus and I are excited to introduce @periodiclabs. Our goal is to create an AI scientist. Science works by conjecturing how the world might be, running experiments, and learning from the results. Intelligence is necessary, but not sufficient. New knowledge is created when ideas are found to be consistent with reality. And so, at Periodic, we are building AI scientists and the autonomous laboratories for them to operate. Until now, scientific AI advances have come from models trained on the internet. But despite its vastness — it’s still finite (estimates are ~10T text tokens where one English word may be 1-2 tokens). And in recent years the best frontier AI models have fully exhausted it. Researchers seek better use of this data, but as any scientist knows: though re-reading a textbook may give new insights, they eventually need to try their idea to see if it holds. Autonomous labs are central to our strategy. They provide huge amounts of high-quality data (each experiment can produce GBs of data!) that exists nowhere else. They generate valuable negative results which are seldom published. But most importantly, they give our AI scientists the tools to act. We’re starting in the physical sciences. Technological progress is limited by our ability to design the physical world. We’re starting here because experiments have high signal-to-noise and are (relatively) fast, physical simulations effectively model many systems, but more broadly, physics is a verifiable environment. AI has progressed fastest in domains with data and verifiable results - for example, in math and code. Here, nature is the RL environment. One of our goals is to discover superconductors that work at higher temperatures than today's materials. Significant advances could help us create next-generation transportation and build power grids with minimal losses. But this is just one example — if we can automate materials design, we have the potential to accelerate Moore’s Law, space travel, and nuclear fusion. We’re also working to deploy our solutions with industry. As an example, we're helping a semiconductor manufacturer that is facing issues with heat dissipation on their chips. We’re training custom agents for their engineers and researchers to make sense of their experimental data in order to iterate faster. Our founding team co-created ChatGPT, DeepMind’s GNoME, OpenAI’s Operator (now Agent), the neural attention mechanism, MatterGen; have scaled autonomous physics labs; and have contributed to some of the most important materials discoveries of the last decade. We’ve come together to scale up and reimagine how science is done. We’re fortunate to be backed by investors who share our vision, including @a16z who led our $300M round, as well as @Felicis, DST Global, NVentures (NVIDIA’s venture capital arm), @Accel and individuals including @JeffBezos , @eladgil , @ericschmidt, and @JeffDean. Their support will help us grow our team, scale our labs, and develop the first generation of AI scientists.

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Brian Hie
Brian Hie@BrianHie·
Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab. Germinal achieves success rates of 4-22% across diverse epitopes. We make the work fully open, without doing lame things like posting a preprint without methods. 🧵
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